General information
PDB ID 4O6A
Title MOUSE CYCLIC GMP-AMP SYNTHASE (CGAS) IN COMPLEX WITH DNA
PDB header TRANSFERASE/DNA
Date 2013-12-20
Experimental method X-RAY DIFFRACTION
Resolution (A) 1.86
Kind dna
Organism MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb4o6a.pdb AB DECF 0
Biounits:
4o6a.pdb1.pdb AB DECF 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Mab-21 Family Q8C6L5_200-495 3e-79 1 No_clan A 200 495 CDEF  H-Bb H-Mn L-Bb 
Mab-21 Family Q8C6L5_200-495 2.9e-79 1 No_clan B 200 495 CDEF  H-Bb L-Bb L-Mn 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/B=147-507 C cytosol
A/B=147-507 C nucleus
A/B=147-507 C plasma membrane
A/B=147-507 C site of double-strand break
A/B=147-507 F ATP binding
A/B=147-507 F chromatin binding
A/B=147-507 F cyclic-GMP-AMP synthase activity
A/B=147-507 F DNA binding
A/B=147-507 F double-stranded DNA binding
A/B=147-507 F GTP binding
A/B=147-507 F metal ion binding
A/B=147-507 F phosphatidylinositol-4,5-bisphosphate binding
A/B=147-507 P activation of innate immune response
A/B=147-507 P cellular response to DNA damage stimulus
A/B=147-507 P cellular response to exogenous dsRNA
A/B=147-507 P defense response to virus
A/B=147-507 P determination of adult lifespan
A/B=147-507 P DNA repair
A/B=147-507 P innate immune response
A/B=147-507 P negative regulation of double-strand break repair via homologous recombination
A/B=147-507 P paracrine signaling
A/B=147-507 P positive regulation of cAMP-mediated signaling
A/B=147-507 P positive regulation of cellular senescence
A/B=147-507 P positive regulation of cGMP-mediated signaling
A/B=147-507 P positive regulation of defense response to virus by host
A/B=147-507 P positive regulation of type I interferon production
A/B=147-507 P regulation of immune response
A/B=147-507 P regulation of immunoglobulin production
A/B=147-507 P regulation of T cell activation
A/B=147-507 P regulation of type I interferon production
Sequences
Download file with secondary structure created by Stride  
4o6a.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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E (dna): 
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F (dna): 
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A (protein): 
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B (protein): 
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