General information
PDB ID 4OPX
Title STRUCTURE OF HUMAN PARP-1 BOUND TO A DNA DOUBLE STRAND BREAK IN COMPLEX WITH (2R)-5-FLUORO-2-METHYL-2,3-DIHYDRO-1-BENZOFURAN-7- CARBOXAMIDE
PDB header TRANSFERASE/DNA/TRANSFERASE INHIBITOR
Date 2014-02-06
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.31
Kind dna
Organism HOMO SAPIENS
Download
complex
View in
Jmol
Quick Links
PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb4opx.pdb ACDF MN 0
Biounits:
4opx.pdb1.pdb AC MN 1
4opx.pdb2.pdb DF MN 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
PADR1 Domain P09874_280-331 1.3e-22 1 CL0306 A 280 331   
zf-PARP Domain P09874_12-89 5.2e-21 1 CL0167 A 12 89 NM  S-Bb S-Mj S-Mn L-Bb L-Mj L-Mn 
PARP_reg Domain P09874_663-794 1.9e-51 1 No_clan C 663 794   
WGR Domain P09874_553-633 5.3e-17 1 No_clan C 553 633 M  H-Bb S-Bb 
PADR1 Domain P09874_280-331 1.3e-22 1 CL0306 D 280 331   
zf-PARP Domain P09874_12-89 5.2e-21 1 CL0167 D 12 89 MN  S-Bb S-Mj S-Mn L-Bb L-Mj L-Mn 
PARP_reg Domain P09874_663-794 1.9e-51 1 No_clan F 663 794   
WGR Domain P09874_553-633 5.3e-17 1 No_clan F 553 633 N  H-Bb S-Bb 
PARP Family P09874_808-1007 4.9e-74 1 CL0084 C 808 1007   
PARP Family P09874_808-1007 4.9e-74 1 CL0084 F 808 1007   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/D=1-97, A/D=207-366, C/F=518-1014 C membrane
A/D=1-97, A/D=207-366, C/F=518-1014 C mitochondrion
A/D=1-97, A/D=207-366, C/F=518-1014 C nuclear body
A/D=1-97, A/D=207-366, C/F=518-1014 C nuclear chromosome, telomeric region
A/D=1-97, A/D=207-366, C/F=518-1014 C nuclear envelope
A/D=1-97, A/D=207-366, C/F=518-1014 C nucleolus
A/D=1-97, A/D=207-366, C/F=518-1014 C nucleoplasm
A/D=1-97, A/D=207-366, C/F=518-1014 C nucleus
A/D=1-97, A/D=207-366, C/F=518-1014 C protein-containing complex
A/D=1-97, A/D=207-366, C/F=518-1014 C protein-DNA complex
A/D=1-97, A/D=207-366, C/F=518-1014 C site of DNA damage
A/D=1-97, A/D=207-366, C/F=518-1014 C site of double-strand break
A/D=1-97, A/D=207-366, C/F=518-1014 C transcription regulator complex
A/D=1-97, A/D=207-366, C/F=518-1014 F DNA binding
A/D=1-97, A/D=207-366, C/F=518-1014 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/D=1-97, A/D=207-366, C/F=518-1014 F enzyme binding
A/D=1-97, A/D=207-366, C/F=518-1014 F estrogen receptor binding
A/D=1-97, A/D=207-366, C/F=518-1014 F histone deacetylase binding
A/D=1-97, A/D=207-366, C/F=518-1014 F identical protein binding
A/D=1-97, A/D=207-366, C/F=518-1014 F NAD binding
A/D=1-97, A/D=207-366, C/F=518-1014 F NAD DNA ADP-ribosyltransferase activity
A/D=1-97, A/D=207-366, C/F=518-1014 F NAD+ ADP-ribosyltransferase activity
A/D=1-97, A/D=207-366, C/F=518-1014 F protein ADP-ribosylase activity
A/D=1-97, A/D=207-366, C/F=518-1014 F protein kinase binding
A/D=1-97, A/D=207-366, C/F=518-1014 F protein N-terminus binding
A/D=1-97, A/D=207-366, C/F=518-1014 F R-SMAD binding
A/D=1-97, A/D=207-366, C/F=518-1014 F RNA binding
A/D=1-97, A/D=207-366, C/F=518-1014 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
A/D=1-97, A/D=207-366, C/F=518-1014 F transcription factor binding
A/D=1-97, A/D=207-366, C/F=518-1014 F zinc ion binding
A/D=1-97, A/D=207-366, C/F=518-1014 P apoptotic process
A/D=1-97, A/D=207-366, C/F=518-1014 P ATP generation from poly-ADP-D-ribose
A/D=1-97, A/D=207-366, C/F=518-1014 P cellular response to amyloid-beta
A/D=1-97, A/D=207-366, C/F=518-1014 P cellular response to DNA damage stimulus
A/D=1-97, A/D=207-366, C/F=518-1014 P cellular response to insulin stimulus
A/D=1-97, A/D=207-366, C/F=518-1014 P cellular response to oxidative stress
A/D=1-97, A/D=207-366, C/F=518-1014 P cellular response to UV
A/D=1-97, A/D=207-366, C/F=518-1014 P cellular response to zinc ion
A/D=1-97, A/D=207-366, C/F=518-1014 P DNA ADP-ribosylation
A/D=1-97, A/D=207-366, C/F=518-1014 P DNA damage response, detection of DNA damage
A/D=1-97, A/D=207-366, C/F=518-1014 P DNA repair
A/D=1-97, A/D=207-366, C/F=518-1014 P double-strand break repair
A/D=1-97, A/D=207-366, C/F=518-1014 P double-strand break repair via homologous recombination
A/D=1-97, A/D=207-366, C/F=518-1014 P global genome nucleotide-excision repair
A/D=1-97, A/D=207-366, C/F=518-1014 P macrophage differentiation
A/D=1-97, A/D=207-366, C/F=518-1014 P mitochondrial DNA metabolic process
A/D=1-97, A/D=207-366, C/F=518-1014 P mitochondrial DNA repair
A/D=1-97, A/D=207-366, C/F=518-1014 P mitochondrion organization
A/D=1-97, A/D=207-366, C/F=518-1014 P negative regulation of ATP biosynthetic process
A/D=1-97, A/D=207-366, C/F=518-1014 P negative regulation of telomere maintenance via telomere lengthening
A/D=1-97, A/D=207-366, C/F=518-1014 P negative regulation of transcription by RNA polymerase II
A/D=1-97, A/D=207-366, C/F=518-1014 P nucleotide-excision repair, DNA damage recognition
A/D=1-97, A/D=207-366, C/F=518-1014 P nucleotide-excision repair, DNA duplex unwinding
A/D=1-97, A/D=207-366, C/F=518-1014 P nucleotide-excision repair, DNA incision
A/D=1-97, A/D=207-366, C/F=518-1014 P nucleotide-excision repair, DNA incision, 3'-to lesion
A/D=1-97, A/D=207-366, C/F=518-1014 P nucleotide-excision repair, DNA incision, 5'-to lesion
A/D=1-97, A/D=207-366, C/F=518-1014 P nucleotide-excision repair, preincision complex assembly
A/D=1-97, A/D=207-366, C/F=518-1014 P nucleotide-excision repair, preincision complex stabilization
A/D=1-97, A/D=207-366, C/F=518-1014 P peptidyl-glutamic acid poly-ADP-ribosylation
A/D=1-97, A/D=207-366, C/F=518-1014 P peptidyl-serine ADP-ribosylation
A/D=1-97, A/D=207-366, C/F=518-1014 P positive regulation of cardiac muscle hypertrophy
A/D=1-97, A/D=207-366, C/F=518-1014 P positive regulation of double-strand break repair via homologous recombination
A/D=1-97, A/D=207-366, C/F=518-1014 P positive regulation of intracellular estrogen receptor signaling pathway
A/D=1-97, A/D=207-366, C/F=518-1014 P positive regulation of mitochondrial depolarization
A/D=1-97, A/D=207-366, C/F=518-1014 P positive regulation of myofibroblast differentiation
A/D=1-97, A/D=207-366, C/F=518-1014 P positive regulation of neuron death
A/D=1-97, A/D=207-366, C/F=518-1014 P positive regulation of protein localization to nucleus
A/D=1-97, A/D=207-366, C/F=518-1014 P positive regulation of single strand break repair
A/D=1-97, A/D=207-366, C/F=518-1014 P positive regulation of SMAD protein signal transduction
A/D=1-97, A/D=207-366, C/F=518-1014 P positive regulation of transcription by RNA polymerase II
A/D=1-97, A/D=207-366, C/F=518-1014 P positive regulation of transcription regulatory region DNA binding
A/D=1-97, A/D=207-366, C/F=518-1014 P protein ADP-ribosylation
A/D=1-97, A/D=207-366, C/F=518-1014 P protein auto-ADP-ribosylation
A/D=1-97, A/D=207-366, C/F=518-1014 P protein autoprocessing
A/D=1-97, A/D=207-366, C/F=518-1014 P protein modification process
A/D=1-97, A/D=207-366, C/F=518-1014 P protein poly-ADP-ribosylation
A/D=1-97, A/D=207-366, C/F=518-1014 P regulation of catalytic activity
A/D=1-97, A/D=207-366, C/F=518-1014 P regulation of cellular protein localization
A/D=1-97, A/D=207-366, C/F=518-1014 P regulation of DNA methylation
A/D=1-97, A/D=207-366, C/F=518-1014 P regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
A/D=1-97, A/D=207-366, C/F=518-1014 P regulation of SMAD protein complex assembly
A/D=1-97, A/D=207-366, C/F=518-1014 P response to aldosterone
A/D=1-97, A/D=207-366, C/F=518-1014 P response to gamma radiation
A/D=1-97, A/D=207-366, C/F=518-1014 P signal transduction involved in regulation of gene expression
A/D=1-97, A/D=207-366, C/F=518-1014 P telomere maintenance
A/D=1-97, A/D=207-366, C/F=518-1014 P transcription by RNA polymerase II
A/D=1-97, A/D=207-366, C/F=518-1014 P transforming growth factor beta receptor signaling pathway
Sequences
Download file with secondary structure created by Stride  
4opx.pdb1.pdb:   [ download sequences in FASTA format ]
M (dna): 
Click "SHOW" for view sequence
N (dna): 
Click "SHOW" for view sequence
A (protein): 
Click "SHOW" for view sequence
C (protein): 
Click "SHOW" for view sequence
4opx.pdb2.pdb:   [ download sequences in FASTA format ]
M (dna): 
Click "SHOW" for view sequence
N (dna): 
Click "SHOW" for view sequence
D (protein): 
Click "SHOW" for view sequence
F (protein): 
Click "SHOW" for view sequence
© NPIDB team 2003 - 2021

text