General information
PDB ID 4Y5W
Title TRANSCRIPTION FACTOR-DNA COMPLEX
PDB header TRANSCRIPTION/DNA
Date 2015-02-12
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.1
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb4y5w.pdb ABDC EFMN 0
Biounits:
4y5w.pdb1.pdb AC MN 1
4y5w.pdb2.pdb BD EF 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
STAT_bind Domain P42226_277-413 4.6e-32 1 CL0073 A 277 413 NM  H-Bb L-Bb 
SH2 Domain P42226_537-616 7.5e-11 1 CL0541 A 537 616   
STAT_bind Domain P42226_277-413 4.1e-31 1 CL0073 B 277 413 EF  H-Bb S-Bb L-Bb 
SH2 Domain P42226_537-616 7.5e-11 1 CL0541 B 537 616   
STAT_bind Domain P42226_277-413 1.1e-24 1 CL0073 C 277 413 MN  S-Bb L-Bb 
SH2 Domain P42226_537-616 5.2e-11 1 CL0541 C 537 616   
STAT_bind Domain P42226_277-413 1e-28 1 CL0073 D 277 413 EF  S-Bb 
SH2 Domain P42226_537-616 5.3e-11 1 CL0541 D 537 616   
STAT_alpha Family P42226_178-268 1.3e-12 1 No_clan A 133 269   
STAT_alpha Family P42226_178-268 1.3e-12 1 No_clan B 133 270   
STAT_alpha Family P42226_178-268 1.8e-12 1 No_clan C 134 270   
STAT_alpha Family P42226_178-268 1.9e-12 1 No_clan D 134 268   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/B/C/D=113-658 C cytosol
A/B/C/D=113-658 C membrane raft
A/B/C/D=113-658 C nuclear chromatin
A/B/C/D=113-658 C nucleoplasm
A/B/C/D=113-658 C nucleus
A/B/C/D=113-658 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/B/C/D=113-658 F DNA-binding transcription factor activity
A/B/C/D=113-658 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/B/C/D=113-658 F identical protein binding
A/B/C/D=113-658 F protein phosphatase binding
A/B/C/D=113-658 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/B/C/D=113-658 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
A/B/C/D=113-658 P cellular response to hydrogen peroxide
A/B/C/D=113-658 P cellular response to reactive nitrogen species
A/B/C/D=113-658 P cytokine-mediated signaling pathway
A/B/C/D=113-658 P defense response
A/B/C/D=113-658 P growth hormone receptor signaling pathway via JAK-STAT
A/B/C/D=113-658 P interleukin-4-mediated signaling pathway
A/B/C/D=113-658 P mammary gland epithelial cell proliferation
A/B/C/D=113-658 P mammary gland morphogenesis
A/B/C/D=113-658 P negative regulation of transcription by RNA polymerase II
A/B/C/D=113-658 P negative regulation of type 2 immune response
A/B/C/D=113-658 P positive regulation of cold-induced thermogenesis
A/B/C/D=113-658 P positive regulation of isotype switching to IgE isotypes
A/B/C/D=113-658 P positive regulation of transcription by RNA polymerase II
A/B/C/D=113-658 P positive regulation of type I interferon production
A/B/C/D=113-658 P receptor signaling pathway via JAK-STAT
A/B/C/D=113-658 P regulation of cell population proliferation
A/B/C/D=113-658 P regulation of transcription by RNA polymerase II
A/B/C/D=113-658 P response to peptide hormone
A/B/C/D=113-658 P signal transduction
A/B/C/D=113-658 P T-helper 1 cell lineage commitment
Sequences
Download file with secondary structure created by Stride  
4y5w.pdb1.pdb:   [ download sequences in FASTA format ]
M (dna): 
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N (dna): 
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A (protein): 
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C (protein): 
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4y5w.pdb2.pdb:   [ download sequences in FASTA format ]
E (dna): 
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F (dna): 
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B (protein): 
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D (protein): 
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