General information
PDB ID 5FLV
Title CRYSTAL STRUCTURE OF NKX2-5 AND TBX5 BOUND TO THE NPPA PROMOTER REGION
PDB header TRANSCRIPTION
Date 2015-10-28
Experimental method X-RAY DIFFRACTION
Resolution (A) 3
Kind dna
Organism MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb5flv.pdb AEIM BCFGJKNO 0
Biounits:
5flv.pdb1.pdb A BC 1
5flv.pdb2.pdb E FG 1
5flv.pdb3.pdb I JK 1
5flv.pdb4.pdb M NO 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
T-box Domain P70326_56-237 9e-77 1 CL0073 A 1056 1238 BC  S-Bb S-Mj L-Bb L-Mj L-Mn 
Homeodomain Domain P42582_142-194 6.8e-19 1 CL0123 A 140 1055 BC  H-Bb H-Mj L-Bb 
T-box Domain P70326_56-237 3.9e-76 1 CL0073 E 1056 1237 FG  H-Mn S-Bb L-Bb L-Mj 
Homeodomain Domain P42582_142-194 1.1e-18 1 CL0123 E 142 194 FG  H-Bb H-Mj L-Bb 
T-box Domain P70326_56-237 6.9e-74 1 CL0073 I 1056 1237 JK  H-Mn S-Bb S-Mj L-Bb L-Mj 
Homeodomain Domain P42582_142-194 1.7e-19 1 CL0123 I 140 194 JK  H-Bb H-Mj L-Bb L-Mn 
T-box Domain P70326_56-237 1.4e-77 1 CL0073 M 1056 1237 NO  H-Mn S-Bb S-Mj L-Bb L-Mj 
Homeodomain Domain P42582_142-194 1.1e-18 1 CL0123 M 142 194 NO  H-Bb H-Mj L-Bb 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/E/I/M=134-197 C cytoplasm
A/E/I/M=134-197 C nucleus
A/E/I/M=134-197 C protein-containing complex
A/E/I/M=134-197 C protein-DNA complex
A/E/I/M=134-197 C RNA polymerase II transcription regulator complex
A/E/I/M=134-197 C transcription regulator complex
A/E/I/M=134-197 F chromatin binding
A/E/I/M=134-197 F DNA binding
A/E/I/M=134-197 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/E/I/M=134-197 F DNA-binding transcription factor activity
A/E/I/M=134-197 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/E/I/M=134-197 F histone deacetylase binding
A/E/I/M=134-197 F identical protein binding
A/E/I/M=134-197 F protein homodimerization activity
A/E/I/M=134-197 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/E/I/M=134-197 F sequence-specific DNA binding
A/E/I/M=134-197 F sequence-specific double-stranded DNA binding
A/E/I/M=134-197 F transcription factor binding
A/E/I/M=134-197 F transcription regulatory region sequence-specific DNA binding
A/E/I/M=134-197 P adult heart development
A/E/I/M=134-197 P apoptotic process involved in heart morphogenesis
A/E/I/M=134-197 P atrial cardiac muscle cell development
A/E/I/M=134-197 P atrial septum morphogenesis
A/E/I/M=134-197 P atrioventricular node cell development
A/E/I/M=134-197 P atrioventricular node cell fate commitment
A/E/I/M=134-197 P atrioventricular node development
A/E/I/M=134-197 P bundle of His development
A/E/I/M=134-197 P cardiac conduction system development
A/E/I/M=134-197 P cardiac muscle cell differentiation
A/E/I/M=134-197 P cardiac muscle cell proliferation
A/E/I/M=134-197 P cardiac muscle contraction
A/E/I/M=134-197 P cardiac muscle tissue development
A/E/I/M=134-197 P cardiac muscle tissue morphogenesis
A/E/I/M=134-197 P cardiac ventricle formation
A/E/I/M=134-197 P cardiac ventricle morphogenesis
A/E/I/M=134-197 P cardiovascular system development
A/E/I/M=134-197 P cell differentiation
A/E/I/M=134-197 P embryonic heart tube development
A/E/I/M=134-197 P embryonic heart tube left/right pattern formation
A/E/I/M=134-197 P endoderm development
A/E/I/M=134-197 P heart contraction
A/E/I/M=134-197 P heart development
A/E/I/M=134-197 P heart looping
A/E/I/M=134-197 P heart morphogenesis
A/E/I/M=134-197 P heart trabecula formation
A/E/I/M=134-197 P hemopoiesis
A/E/I/M=134-197 P negative regulation of apoptotic process
A/E/I/M=134-197 P negative regulation of canonical Wnt signaling pathway
A/E/I/M=134-197 P negative regulation of cardiac muscle cell apoptotic process
A/E/I/M=134-197 P negative regulation of myotube differentiation
A/E/I/M=134-197 P negative regulation of transcription by RNA polymerase II
A/E/I/M=134-197 P outflow tract morphogenesis
A/E/I/M=134-197 P outflow tract septum morphogenesis
A/E/I/M=134-197 P pharyngeal system development
A/E/I/M=134-197 P positive regulation of cardioblast differentiation
A/E/I/M=134-197 P positive regulation of cell population proliferation
A/E/I/M=134-197 P positive regulation of gene expression
A/E/I/M=134-197 P positive regulation of heart contraction
A/E/I/M=134-197 P positive regulation of neuron differentiation
A/E/I/M=134-197 P positive regulation of sodium ion transport
A/E/I/M=134-197 P positive regulation of transcription by RNA polymerase II
A/E/I/M=134-197 P positive regulation of transcription initiation from RNA polymerase II promoter
A/E/I/M=134-197 P positive regulation of transcription via serum response element binding
A/E/I/M=134-197 P positive regulation of transcription, DNA-templated
A/E/I/M=134-197 P proepicardium development
A/E/I/M=134-197 P pulmonary myocardium development
A/E/I/M=134-197 P Purkinje myocyte differentiation
A/E/I/M=134-197 P regulation of cardiac conduction
A/E/I/M=134-197 P regulation of cardiac muscle cell proliferation
A/E/I/M=134-197 P regulation of cardiac muscle contraction
A/E/I/M=134-197 P regulation of transcription by RNA polymerase II
A/E/I/M=134-197 P right ventricular cardiac muscle tissue morphogenesis
A/E/I/M=134-197 P sarcomere organization
A/E/I/M=134-197 P septum secundum development
A/E/I/M=134-197 P spleen development
A/E/I/M=134-197 P thyroid gland development
A/E/I/M=134-197 P tongue development
A/E/I/M=134-197 P vasculogenesis
A/E/I/M=134-197 P ventricular cardiac muscle cell development
A/E/I/M=134-197 P ventricular cardiac myofibril assembly
A/E/I/M=134-197 P ventricular septum morphogenesis
A/E/I/M=134-197 P ventricular trabecula myocardium morphogenesis
A/E/I/M=51-251 C cytoplasm
A/E/I/M=51-251 C nucleus
A/E/I/M=51-251 C protein-containing complex
A/E/I/M=51-251 C protein-DNA complex
A/E/I/M=51-251 F DNA binding
A/E/I/M=51-251 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/E/I/M=51-251 F DNA-binding transcription factor activity
A/E/I/M=51-251 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/E/I/M=51-251 F RNA polymerase II activating transcription factor binding
A/E/I/M=51-251 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/E/I/M=51-251 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
A/E/I/M=51-251 F sequence-specific DNA binding
A/E/I/M=51-251 F transcription factor binding
A/E/I/M=51-251 P animal organ development
A/E/I/M=51-251 P atrial septum development
A/E/I/M=51-251 P atrial septum morphogenesis
A/E/I/M=51-251 P atrioventricular valve morphogenesis
A/E/I/M=51-251 P bundle of His development
A/E/I/M=51-251 P cardiac left ventricle formation
A/E/I/M=51-251 P cardiac muscle cell differentiation
A/E/I/M=51-251 P cell fate specification
A/E/I/M=51-251 P cell-cell signaling
A/E/I/M=51-251 P embryonic forelimb morphogenesis
A/E/I/M=51-251 P embryonic limb morphogenesis
A/E/I/M=51-251 P endocardial cushion development
A/E/I/M=51-251 P forelimb morphogenesis
A/E/I/M=51-251 P heart development
A/E/I/M=51-251 P lung development
A/E/I/M=51-251 P morphogenesis of an epithelium
A/E/I/M=51-251 P negative regulation of cardiac muscle cell proliferation
A/E/I/M=51-251 P negative regulation of cell migration
A/E/I/M=51-251 P negative regulation of cell population proliferation
A/E/I/M=51-251 P negative regulation of transcription by RNA polymerase II
A/E/I/M=51-251 P pattern specification process
A/E/I/M=51-251 P pericardium development
A/E/I/M=51-251 P positive regulation of cardiac muscle cell proliferation
A/E/I/M=51-251 P positive regulation of cardioblast differentiation
A/E/I/M=51-251 P positive regulation of secondary heart field cardioblast proliferation
A/E/I/M=51-251 P positive regulation of transcription by RNA polymerase II
A/E/I/M=51-251 P positive regulation of transcription, DNA-templated
A/E/I/M=51-251 P regulation of transcription, DNA-templated
A/E/I/M=51-251 P transdifferentiation
A/E/I/M=51-251 P ventricular cardiac muscle tissue development
A/E/I/M=51-251 P ventricular septum development
Sequences
Download file with secondary structure created by Stride  
5flv.pdb1.pdb:   [ download sequences in FASTA format ]
B (dna): 
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C (dna): 
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A (protein): 
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5flv.pdb2.pdb:   [ download sequences in FASTA format ]
F (dna): 
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G (dna): 
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E (protein): 
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5flv.pdb3.pdb:   [ download sequences in FASTA format ]
J (dna): 
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K (dna): 
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I (protein): 
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5flv.pdb4.pdb:   [ download sequences in FASTA format ]
N (dna): 
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O (dna): 
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M (protein): 
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