General information
PDB ID 5IY7
Title HUMAN HOLO-PIC IN THE OPEN STATE
PDB header TRANSCRIPTION, TRANSFERASE/DNA
Date 2016-03-24
Experimental method ELECTRON MICROSCOPY
Resolution (A) 8.6
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb5iy7.pdb ABCDEFGHIJKLMNOPQRSTUVW0123 XY 0
Biounits:
5iy7.pdb1.pdb ABCDEFGHIJKLMNOPQRSTUVW0123 XY 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Tfb2_C Domain Q92759_389-456 1.4e-23 1 No_clan 2 389 456   
Tfb4 Domain Q13889_8-231 1.1e-61 1 CL0128 3 8 231   
RNA_pol_Rpb1_1 Domain P24928_15-354 1.7e-109 1 No_clan A 15 354 XY  H-Bb S-Bb 
RNA_pol_Rpb1_5 Domain P24928_830-1427 5.1e-101 1 No_clan A 830 1427 XY  L-Bb 
RNA_pol_Rpb1_2 Domain P24928_356-521 2.2e-74 1 No_clan A 356 521   
RNA_pol_Rpb1_6 Domain P24928_896-1079 1.7e-68 1 No_clan A 896 1079   
RNA_pol_Rpb1_7 Domain P24928_1164-1299 1.1e-54 1 No_clan A 1164 1299   
RNA_pol_Rpb1_3 Domain P24928_524-692 1.2e-49 1 No_clan A 524 692   
RNA_pol_Rpb1_4 Domain P24928_716-823 6.5e-38 1 No_clan A 716 823   
RNA_pol_Rpb2_6 Domain P30876_707-1080 3e-128 1 CL0410 B 707 1080 Y   
RNA_pol_Rpb2_2 Domain P30876_201-394 9.5e-56 1 No_clan B 201 394 X   
RNA_pol_Rpb2_7 Domain P30876_1082-1174 6.3e-34 1 No_clan B 1082 1174 Y   
RNA_pol_Rpb2_4 Domain P30876_567-629 2.8e-24 1 No_clan B 567 629   
RNA_pol_Rpb2_3 Domain P30876_468-532 1.1e-23 1 No_clan B 468 532 XY   
RNA_pol_Rpb2_5 Domain P30876_653-700 2.3e-16 1 No_clan B 653 700   
RNA_pol_A_bac Domain P19387_50-177 5.6e-40 1 No_clan C 50 177   
RNA_pol_L Domain P19387_20-256 3.4e-17 1 CL0509 C 20 256   
RNA_pol_Rpb5_C Domain P19388_137-209 2.8e-34 1 No_clan E 137 209   
RNA_pol_Rpb5_N Domain P19388_4-94 1.1e-32 1 CL0236 E 4 94 X  H-Bb 
S1 Domain P62487_78-161 1e-20 1 CL0021 G 78 161   
SHS2_Rpb7-N Domain P62487_8-64 2.7e-10 1 CL0319 G 8 64   
RNA_POL_M_15KD Domain P36954_14-51 4.5e-17 1 CL0167 I 14 51   
TFIIS_C Domain P36954_84-124 9.3e-12 1 CL0167 I 84 124   
RNA_pol_N Domain P62875_2-59 3.6e-32 1 No_clan J 2 59   
RNA_pol_L_2 Domain P52435_30-104 3.4e-29 1 CL0509 K 30 104   
DNA_RNApol_7kD Domain P53803_17-48 8.3e-18 1 CL0167 L 17 48   
TFIIB Domain Q00403_110-201 3.4e-28 1 CL0065 M 110 201 XY  H-Bb L-Bb 
TFIIB Domain Q00403_204-295 3.6e-27 1 CL0065 M 204 295 XY  H-Bb L-Bb 
TF_Zn_Ribbon Domain Q00403_13-54 4.3e-14 1 CL0167 M 13 55   
TFIIA_gamma_N Domain P52657_3-48 4.7e-23 1 No_clan O 2 48   
TFIIA_gamma_C Domain P52657_59-99 7.1e-21 1 No_clan O 59 99   
TBP Domain P20226_162-244 6.7e-33 1 CL0407 P 162 244 XY  S-Bb S-Mn L-Bb L-Mn 
TBP Domain P20226_252-335 1.1e-31 1 CL0407 P 252 335 XY  S-Bb S-Mn L-Bb L-Mj L-Mn 
TF_Zn_Ribbon Domain P29083_127-176 4.9e-14 1 CL0167 Q 127 176   
TFIIE_beta Domain P29084_75-145 2.5e-23 1 CL0123 R 75 145   
TFA2_Winged_2 Domain P29084_146-204 1.1e-08 1 CL0123 R 146 204   
TFIIF_beta Domain P13984_176-238 5.4e-25 1 CL0123 T 176 238 XY  H-Bb L-Bb L-Mn 
TFIIS_M Domain P23193_136-248 1.1e-38 1 No_clan U 136 248   
TFIIS_C Domain P23193_261-299 2.7e-19 1 CL0167 U 261 299   
ERCC3_RAD25_C Domain P19447_496-718 2e-123 1 CL0023 V 496 718 Y  H-Bb 
Helicase_C_2 Domain P18074_524-700 3.2e-45 1 CL0023 W 524 700   
HBB Domain P18074_269-413 5.1e-21 1 No_clan W 269 395   
Ssl1 Family Q13888_64-241 3.3e-88 1 CL0128 0 64 241   
Tfb5 Family Q6ZYL4_1-62 1.9e-25 1 No_clan 1 1 62   
Tfb2 Family Q92759_28-274 1e-38 1 No_clan 2 139 405   
Tfb2 Family Q92759_2-60 1.4e-10 1 No_clan 2 28 99   
RNA_pol_Rpb2_1 Family P30876_38-442 6.3e-68 1 No_clan B 38 442 XY   
RNA_pol_Rpb4 Family O15514_31-138 1.2e-25 1 CL0426 D 31 138   
RNA_pol_Rpb6 Family P61218_51-104 2.5e-13 1 No_clan F 51 104   
RNA_pol_Rpb8 Family P52434_7-147 5.9e-54 1 CL0021 H 7 147   
TFIIA Family P52655_307-376 1.4e-42 1 No_clan N 51 376 XY  S-Bb 
TFIIA Family P52655_13-51 5.3e-17 1 No_clan N 13 309   
TFIIE_alpha Family P29083_16-123 2.7e-28 1 CL0123 Q 16 123 X  H-Bb 
TFIIF_alpha Family P35269_5-180 1.7e-47 1 CL0123 S 52 180   
TFIIF_beta_N Family P13984_15-198 2.8e-13 1 CL0662 T 15 105   
DBD_Tnp_Mut Family P23193_98-168 0.00022 0 CL0274 U 228 298   
ResIII Family P19447_313-472 1.6e-15 1 CL0023 V 313 472 XY  L-Bb 
DEAD_2 Family P18074_72-256 1.6e-46 1 CL0023 W 72 256   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
0=1-395 C core TFIIH complex portion of holo TFIIH complex
0=1-395 C nuclear speck
0=1-395 C nucleoplasm
0=1-395 C nucleus
0=1-395 C transcription factor TFIID complex
0=1-395 C transcription factor TFIIH core complex
0=1-395 C transcription factor TFIIH holo complex
0=1-395 F protein N-terminus binding
0=1-395 F RNA polymerase II general transcription initiation factor activity
0=1-395 F zinc ion binding
0=1-395 P 7-methylguanosine mRNA capping
0=1-395 P G protein-coupled receptor internalization
0=1-395 P global genome nucleotide-excision repair
0=1-395 P nucleotide-excision repair
0=1-395 P nucleotide-excision repair, DNA duplex unwinding
0=1-395 P nucleotide-excision repair, DNA incision
0=1-395 P nucleotide-excision repair, DNA incision, 3'-to lesion
0=1-395 P nucleotide-excision repair, DNA incision, 5'-to lesion
0=1-395 P nucleotide-excision repair, preincision complex assembly
0=1-395 P nucleotide-excision repair, preincision complex stabilization
0=1-395 P positive regulation of DNA helicase activity
0=1-395 P regulation of transcription by RNA polymerase II
0=1-395 P response to UV
0=1-395 P termination of RNA polymerase I transcription
0=1-395 P transcription by RNA polymerase II
0=1-395 P transcription elongation from RNA polymerase I promoter
0=1-395 P transcription elongation from RNA polymerase II promoter
0=1-395 P transcription initiation from RNA polymerase I promoter
0=1-395 P transcription initiation from RNA polymerase II promoter
0=1-395 P transcription-coupled nucleotide-excision repair
0=1-395 P viral process
1=1-71 C nucleolus
1=1-71 C nucleoplasm
1=1-71 C transcription factor TFIID complex
1=1-71 C transcription factor TFIIH core complex
1=1-71 C transcription factor TFIIH holo complex
1=1-71 P 7-methylguanosine mRNA capping
1=1-71 P cellular response to gamma radiation
1=1-71 P global genome nucleotide-excision repair
1=1-71 P maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
1=1-71 P nucleotide-excision repair
1=1-71 P nucleotide-excision repair, DNA duplex unwinding
1=1-71 P nucleotide-excision repair, DNA incision
1=1-71 P nucleotide-excision repair, DNA incision, 3'-to lesion
1=1-71 P nucleotide-excision repair, DNA incision, 5'-to lesion
1=1-71 P nucleotide-excision repair, preincision complex assembly
1=1-71 P nucleotide-excision repair, preincision complex stabilization
1=1-71 P phosphorylation of RNA polymerase II C-terminal domain
1=1-71 P termination of RNA polymerase I transcription
1=1-71 P transcription by RNA polymerase II
1=1-71 P transcription elongation from RNA polymerase I promoter
1=1-71 P transcription elongation from RNA polymerase II promoter
1=1-71 P transcription initiation from RNA polymerase I promoter
1=1-71 P transcription initiation from RNA polymerase II promoter
1=1-71 P transcription-coupled nucleotide-excision repair
2=1-462 C core TFIIH complex portion of holo TFIIH complex
2=1-462 C nuclear speck
2=1-462 C nucleoplasm
2=1-462 C nucleus
2=1-462 C transcription factor TFIID complex
2=1-462 C transcription factor TFIIH core complex
2=1-462 C transcription factor TFIIH holo complex
2=1-462 F ATPase activator activity
2=1-462 F double-stranded DNA binding
2=1-462 F RNA polymerase II general transcription initiation factor activity
2=1-462 P 7-methylguanosine mRNA capping
2=1-462 P DNA repair
2=1-462 P global genome nucleotide-excision repair
2=1-462 P nucleotide-excision repair
2=1-462 P nucleotide-excision repair, DNA duplex unwinding
2=1-462 P nucleotide-excision repair, DNA incision
2=1-462 P nucleotide-excision repair, DNA incision, 3'-to lesion
2=1-462 P nucleotide-excision repair, DNA incision, 5'-to lesion
2=1-462 P nucleotide-excision repair, preincision complex assembly
2=1-462 P nucleotide-excision repair, preincision complex stabilization
2=1-462 P phosphorylation of RNA polymerase II C-terminal domain
2=1-462 P termination of RNA polymerase I transcription
2=1-462 P transcription by RNA polymerase II
2=1-462 P transcription elongation from RNA polymerase I promoter
2=1-462 P transcription elongation from RNA polymerase II promoter
2=1-462 P transcription initiation from RNA polymerase I promoter
2=1-462 P transcription initiation from RNA polymerase II promoter
2=1-462 P transcription-coupled nucleotide-excision repair
3=1-308 C core TFIIH complex portion of holo TFIIH complex
3=1-308 C nucleoplasm
3=1-308 C nucleus
3=1-308 C transcription factor TFIID complex
3=1-308 C transcription factor TFIIH core complex
3=1-308 C transcription factor TFIIH holo complex
3=1-308 C transcription preinitiation complex
3=1-308 F metal ion binding
3=1-308 F protein N-terminus binding
3=1-308 F RNA polymerase II general transcription initiation factor activity
3=1-308 P 7-methylguanosine mRNA capping
3=1-308 P DNA repair
3=1-308 P global genome nucleotide-excision repair
3=1-308 P nucleotide-excision repair
3=1-308 P nucleotide-excision repair, DNA duplex unwinding
3=1-308 P nucleotide-excision repair, DNA incision
3=1-308 P nucleotide-excision repair, DNA incision, 3'-to lesion
3=1-308 P nucleotide-excision repair, DNA incision, 5'-to lesion
3=1-308 P nucleotide-excision repair, preincision complex assembly
3=1-308 P nucleotide-excision repair, preincision complex stabilization
3=1-308 P phosphorylation of RNA polymerase II C-terminal domain
3=1-308 P termination of RNA polymerase I transcription
3=1-308 P transcription by RNA polymerase II
3=1-308 P transcription elongation from RNA polymerase I promoter
3=1-308 P transcription elongation from RNA polymerase II promoter
3=1-308 P transcription initiation from RNA polymerase I promoter
3=1-308 P transcription initiation from RNA polymerase II promoter
3=1-308 P transcription-coupled nucleotide-excision repair
A=1-1970 C chromosome
A=1-1970 C cytoplasm
A=1-1970 C nucleoplasm
A=1-1970 C nucleus
A=1-1970 C RNA polymerase II, core complex
A=1-1970 F DNA binding
A=1-1970 F DNA-directed 5'-3' RNA polymerase activity
A=1-1970 F kinase binding
A=1-1970 F metal ion binding
A=1-1970 F promoter-specific chromatin binding
A=1-1970 F protein C-terminus binding
A=1-1970 F RNA binding
A=1-1970 F RNA-directed 5'-3' RNA polymerase activity
A=1-1970 F ubiquitin protein ligase binding
A=1-1970 P 7-methylguanosine mRNA capping
A=1-1970 P DNA-templated transcription, termination
A=1-1970 P fibroblast growth factor receptor signaling pathway
A=1-1970 P mRNA splicing, via spliceosome
A=1-1970 P positive regulation of RNA splicing
A=1-1970 P positive regulation of viral transcription
A=1-1970 P regulation of gene silencing by miRNA
A=1-1970 P regulation of transcription, DNA-templated
A=1-1970 P RNA metabolic process
A=1-1970 P snRNA transcription by RNA polymerase II
A=1-1970 P somatic stem cell population maintenance
A=1-1970 P transcription by RNA polymerase II
A=1-1970 P transcription elongation from RNA polymerase II promoter
A=1-1970 P transcription initiation from RNA polymerase II promoter
A=1-1970 P transcription, DNA-templated
A=1-1970 P transcription-coupled nucleotide-excision repair
A=1-1970 P viral process
B=1-1174 C membrane
B=1-1174 C nucleoplasm
B=1-1174 C nucleus
B=1-1174 C RNA polymerase II, core complex
B=1-1174 F chromatin binding
B=1-1174 F DNA binding
B=1-1174 F DNA-directed 5'-3' RNA polymerase activity
B=1-1174 F metal ion binding
B=1-1174 F ribonucleoside binding
B=1-1174 F RNA binding
B=1-1174 P 7-methylguanosine mRNA capping
B=1-1174 P fibroblast growth factor receptor signaling pathway
B=1-1174 P mRNA splicing, via spliceosome
B=1-1174 P positive regulation of viral transcription
B=1-1174 P regulation of gene silencing by miRNA
B=1-1174 P RNA metabolic process
B=1-1174 P snRNA transcription by RNA polymerase II
B=1-1174 P somatic stem cell population maintenance
B=1-1174 P transcription by RNA polymerase II
B=1-1174 P transcription elongation from RNA polymerase II promoter
B=1-1174 P transcription initiation from RNA polymerase II promoter
B=1-1174 P transcription, DNA-templated
B=1-1174 P transcription-coupled nucleotide-excision repair
C=1-275 C cytosol
C=1-275 C microtubule cytoskeleton
C=1-275 C nucleoplasm
C=1-275 C nucleus
C=1-275 C RNA polymerase II, core complex
C=1-275 F DNA binding
C=1-275 F DNA-directed 5'-3' RNA polymerase activity
C=1-275 F protein dimerization activity
C=1-275 P 7-methylguanosine mRNA capping
C=1-275 P fibroblast growth factor receptor signaling pathway
C=1-275 P mRNA splicing, via spliceosome
C=1-275 P positive regulation of viral transcription
C=1-275 P regulation of gene silencing by miRNA
C=1-275 P RNA metabolic process
C=1-275 P snRNA transcription by RNA polymerase II
C=1-275 P somatic stem cell population maintenance
C=1-275 P transcription by RNA polymerase II
C=1-275 P transcription elongation from RNA polymerase II promoter
C=1-275 P transcription initiation from RNA polymerase II promoter
C=1-275 P transcription, DNA-templated
C=1-275 P transcription-coupled nucleotide-excision repair
D=1-142 C cytosol
D=1-142 C nuclear speck
D=1-142 C nucleoplasm
D=1-142 C nucleus
D=1-142 C P-body
D=1-142 C RNA polymerase II, core complex
D=1-142 F DNA-directed 5'-3' RNA polymerase activity
D=1-142 F nucleotide binding
D=1-142 F translation initiation factor binding
D=1-142 P 7-methylguanosine mRNA capping
D=1-142 P fibroblast growth factor receptor signaling pathway
D=1-142 P mRNA export from nucleus in response to heat stress
D=1-142 P mRNA splicing, via spliceosome
D=1-142 P nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
D=1-142 P positive regulation of translational initiation
D=1-142 P positive regulation of viral transcription
D=1-142 P recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex
D=1-142 P regulation of gene silencing by miRNA
D=1-142 P RNA metabolic process
D=1-142 P snRNA transcription by RNA polymerase II
D=1-142 P somatic stem cell population maintenance
D=1-142 P transcription by RNA polymerase II
D=1-142 P transcription elongation from RNA polymerase II promoter
D=1-142 P transcription initiation from RNA polymerase II promoter
D=1-142 P transcription, DNA-templated
D=1-142 P transcription-coupled nucleotide-excision repair
E=1-210 C cytosol
E=1-210 C host cell nucleus
E=1-210 C nucleoplasm
E=1-210 C nucleus
E=1-210 C RNA polymerase I complex
E=1-210 C RNA polymerase II, core complex
E=1-210 C RNA polymerase III complex
E=1-210 F DNA binding
E=1-210 F DNA-directed 5'-3' RNA polymerase activity
E=1-210 P 7-methylguanosine mRNA capping
E=1-210 P fibroblast growth factor receptor signaling pathway
E=1-210 P mRNA splicing, via spliceosome
E=1-210 P positive regulation of gene expression, epigenetic
E=1-210 P positive regulation of type I interferon production
E=1-210 P positive regulation of viral transcription
E=1-210 P regulation of gene silencing by miRNA
E=1-210 P RNA metabolic process
E=1-210 P snRNA transcription by RNA polymerase II
E=1-210 P somatic stem cell population maintenance
E=1-210 P termination of RNA polymerase I transcription
E=1-210 P transcription by RNA polymerase II
E=1-210 P transcription elongation from RNA polymerase I promoter
E=1-210 P transcription elongation from RNA polymerase II promoter
E=1-210 P transcription initiation from RNA polymerase I promoter
E=1-210 P transcription initiation from RNA polymerase II promoter
E=1-210 P transcription, DNA-templated
E=1-210 P transcription-coupled nucleotide-excision repair
E=1-210 P viral process
F=1-127 C cytosol
F=1-127 C fibrillar center
F=1-127 C nucleoplasm
F=1-127 C nucleus
F=1-127 C RNA polymerase I complex
F=1-127 C RNA polymerase II, core complex
F=1-127 C RNA polymerase III complex
F=1-127 F DNA binding
F=1-127 F DNA-directed 5'-3' RNA polymerase activity
F=1-127 P 7-methylguanosine mRNA capping
F=1-127 P fibroblast growth factor receptor signaling pathway
F=1-127 P mRNA splicing, via spliceosome
F=1-127 P positive regulation of gene expression, epigenetic
F=1-127 P positive regulation of type I interferon production
F=1-127 P positive regulation of viral transcription
F=1-127 P regulation of gene silencing by miRNA
F=1-127 P RNA metabolic process
F=1-127 P snRNA transcription by RNA polymerase II
F=1-127 P somatic stem cell population maintenance
F=1-127 P termination of RNA polymerase I transcription
F=1-127 P transcription by RNA polymerase II
F=1-127 P transcription elongation from RNA polymerase I promoter
F=1-127 P transcription elongation from RNA polymerase II promoter
F=1-127 P transcription initiation from RNA polymerase I promoter
F=1-127 P transcription initiation from RNA polymerase II promoter
F=1-127 P transcription, DNA-templated
F=1-127 P transcription-coupled nucleotide-excision repair
G=1-172 C nucleoplasm
G=1-172 C nucleus
G=1-172 C P-body
G=1-172 C RNA polymerase II, core complex
G=1-172 F DNA-directed 5'-3' RNA polymerase activity
G=1-172 F single-stranded DNA binding
G=1-172 F single-stranded RNA binding
G=1-172 F translation initiation factor binding
G=1-172 P 7-methylguanosine mRNA capping
G=1-172 P apoptotic process
G=1-172 P fibroblast growth factor receptor signaling pathway
G=1-172 P mRNA splicing, via spliceosome
G=1-172 P nuclear-transcribed mRNA catabolic process, exonucleolytic
G=1-172 P positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
G=1-172 P positive regulation of translational initiation
G=1-172 P positive regulation of viral transcription
G=1-172 P regulation of gene silencing by miRNA
G=1-172 P RNA metabolic process
G=1-172 P snRNA transcription by RNA polymerase II
G=1-172 P somatic stem cell population maintenance
G=1-172 P transcription by RNA polymerase II
G=1-172 P transcription elongation from RNA polymerase II promoter
G=1-172 P transcription initiation from RNA polymerase II promoter
G=1-172 P transcription, DNA-templated
G=1-172 P transcription-coupled nucleotide-excision repair
H=1-150 C cytosol
H=1-150 C nucleoplasm
H=1-150 C nucleus
H=1-150 C protein-DNA complex
H=1-150 C RNA polymerase I complex
H=1-150 C RNA polymerase II, core complex
H=1-150 C RNA polymerase III complex
H=1-150 F DNA-directed 5'-3' RNA polymerase activity
H=1-150 F single-stranded DNA binding
H=1-150 P 7-methylguanosine mRNA capping
H=1-150 P fibroblast growth factor receptor signaling pathway
H=1-150 P mRNA splicing, via spliceosome
H=1-150 P positive regulation of gene expression, epigenetic
H=1-150 P positive regulation of type I interferon production
H=1-150 P positive regulation of viral transcription
H=1-150 P regulation of gene silencing by miRNA
H=1-150 P RNA metabolic process
H=1-150 P snRNA transcription by RNA polymerase II
H=1-150 P somatic stem cell population maintenance
H=1-150 P termination of RNA polymerase I transcription
H=1-150 P transcription by RNA polymerase II
H=1-150 P transcription elongation from RNA polymerase I promoter
H=1-150 P transcription elongation from RNA polymerase II promoter
H=1-150 P transcription initiation from RNA polymerase I promoter
H=1-150 P transcription initiation from RNA polymerase II promoter
H=1-150 P transcription, DNA-templated
H=1-150 P transcription-coupled nucleotide-excision repair
I=1-125 C nucleolus
I=1-125 C nucleoplasm
I=1-125 C nucleus
I=1-125 C RNA polymerase II, core complex
I=1-125 F DNA-directed 5'-3' RNA polymerase activity
I=1-125 F nucleic acid binding
I=1-125 F zinc ion binding
I=1-125 P 7-methylguanosine mRNA capping
I=1-125 P fibroblast growth factor receptor signaling pathway
I=1-125 P maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter
I=1-125 P mRNA cleavage
I=1-125 P mRNA splicing, via spliceosome
I=1-125 P positive regulation of viral transcription
I=1-125 P regulation of gene silencing by miRNA
I=1-125 P RNA metabolic process
I=1-125 P snRNA transcription by RNA polymerase II
I=1-125 P somatic stem cell population maintenance
I=1-125 P transcription by RNA polymerase II
I=1-125 P transcription elongation from RNA polymerase II promoter
I=1-125 P transcription initiation from RNA polymerase II promoter
I=1-125 P transcription, DNA-templated
I=1-125 P transcription-coupled nucleotide-excision repair
J=1-67 C cytosol
J=1-67 C nucleoplasm
J=1-67 C nucleus
J=1-67 C RNA polymerase I complex
J=1-67 C RNA polymerase II, core complex
J=1-67 C RNA polymerase III complex
J=1-67 F DNA binding
J=1-67 F DNA-directed 5'-3' RNA polymerase activity
J=1-67 F zinc ion binding
J=1-67 P 7-methylguanosine mRNA capping
J=1-67 P fibroblast growth factor receptor signaling pathway
J=1-67 P mRNA splicing, via spliceosome
J=1-67 P positive regulation of gene expression, epigenetic
J=1-67 P positive regulation of type I interferon production
J=1-67 P positive regulation of viral transcription
J=1-67 P regulation of gene silencing by miRNA
J=1-67 P regulation of transcription by RNA polymerase I
J=1-67 P RNA metabolic process
J=1-67 P snRNA transcription by RNA polymerase II
J=1-67 P somatic stem cell population maintenance
J=1-67 P termination of RNA polymerase I transcription
J=1-67 P transcription by RNA polymerase I
J=1-67 P transcription by RNA polymerase II
J=1-67 P transcription elongation from RNA polymerase I promoter
J=1-67 P transcription elongation from RNA polymerase II promoter
J=1-67 P transcription initiation from RNA polymerase I promoter
J=1-67 P transcription initiation from RNA polymerase II promoter
J=1-67 P transcription, DNA-templated
J=1-67 P transcription-coupled nucleotide-excision repair
J=1-67 P tRNA transcription by RNA polymerase III
K=1-117 C nucleoplasm
K=1-117 C nucleus
K=1-117 C RNA polymerase II, core complex
K=1-117 F DNA binding
K=1-117 F DNA-directed 5'-3' RNA polymerase activity
K=1-117 F LRR domain binding
K=1-117 F protein dimerization activity
K=1-117 F RNA polymerase II activity
K=1-117 P 7-methylguanosine mRNA capping
K=1-117 P fibroblast growth factor receptor signaling pathway
K=1-117 P mRNA splicing, via spliceosome
K=1-117 P positive regulation of viral transcription
K=1-117 P regulation of gene silencing by miRNA
K=1-117 P RNA metabolic process
K=1-117 P snRNA transcription by RNA polymerase II
K=1-117 P somatic stem cell population maintenance
K=1-117 P transcription by RNA polymerase II
K=1-117 P transcription elongation from RNA polymerase II promoter
K=1-117 P transcription initiation from RNA polymerase II promoter
K=1-117 P transcription, DNA-templated
K=1-117 P transcription-coupled nucleotide-excision repair
L=1-58 C cytosol
L=1-58 C nucleoplasm
L=1-58 C nucleus
L=1-58 C RNA polymerase I complex
L=1-58 C RNA polymerase II, core complex
L=1-58 C RNA polymerase III complex
L=1-58 F DNA binding
L=1-58 F DNA-directed 5'-3' RNA polymerase activity
L=1-58 F zinc ion binding
L=1-58 P 7-methylguanosine mRNA capping
L=1-58 P fibroblast growth factor receptor signaling pathway
L=1-58 P mRNA splicing, via spliceosome
L=1-58 P positive regulation of gene expression, epigenetic
L=1-58 P positive regulation of type I interferon production
L=1-58 P positive regulation of viral transcription
L=1-58 P regulation of gene silencing by miRNA
L=1-58 P regulation of transcription by RNA polymerase I
L=1-58 P RNA metabolic process
L=1-58 P snRNA transcription by RNA polymerase II
L=1-58 P somatic stem cell population maintenance
L=1-58 P termination of RNA polymerase I transcription
L=1-58 P transcription by RNA polymerase II
L=1-58 P transcription by RNA polymerase III
L=1-58 P transcription elongation from RNA polymerase I promoter
L=1-58 P transcription elongation from RNA polymerase II promoter
L=1-58 P transcription initiation from RNA polymerase I promoter
L=1-58 P transcription initiation from RNA polymerase II promoter
L=1-58 P transcription, DNA-templated
L=1-58 P transcription-coupled nucleotide-excision repair
M=1-316 C chromosome
M=1-316 C nuclear body
M=1-316 C nucleoplasm
M=1-316 C nucleus
M=1-316 C protein-DNA complex
M=1-316 C RNA polymerase II transcription regulator complex
M=1-316 C transcription factor TFIID complex
M=1-316 C transcription preinitiation complex
M=1-316 F acetyltransferase activity
M=1-316 F core promoter sequence-specific DNA binding
M=1-316 F histone acetyltransferase activity
M=1-316 F promoter-specific chromatin binding
M=1-316 F RNA polymerase II complex binding
M=1-316 F RNA polymerase II complex recruiting activity
M=1-316 F RNA polymerase II core promoter sequence-specific DNA binding
M=1-316 F RNA polymerase II general transcription initiation factor activity
M=1-316 F TBP-class protein binding
M=1-316 F thyroid hormone receptor binding
M=1-316 F transcription factor binding
M=1-316 F zinc ion binding
M=1-316 P DNA-templated transcription, initiation
M=1-316 P positive regulation by host of viral transcription
M=1-316 P positive regulation of core promoter binding
M=1-316 P positive regulation of transcription initiation from RNA polymerase II promoter
M=1-316 P positive regulation of viral transcription
M=1-316 P protein acetylation
M=1-316 P RNA polymerase II core complex assembly
M=1-316 P RNA polymerase II preinitiation complex assembly
M=1-316 P snRNA transcription by RNA polymerase II
M=1-316 P transcription by RNA polymerase II
M=1-316 P transcription initiation from RNA polymerase II promoter
M=1-316 P transcriptional start site selection at RNA polymerase II promoter
M=1-316 P viral process
N=1-376 C cytosol
N=1-376 C nucleoplasm
N=1-376 C transcription factor TFIIA complex
N=1-376 C transcription factor TFIID complex
N=1-376 C transcription preinitiation complex
N=1-376 F DNA binding
N=1-376 F protein heterodimerization activity
N=1-376 F RNA polymerase II core promoter sequence-specific DNA binding
N=1-376 F RNA polymerase II general transcription initiation factor activity
N=1-376 F RNA polymerase II repressing transcription factor binding
N=1-376 F TBP-class protein binding
N=1-376 F transcription factor binding
N=1-376 P snRNA transcription by RNA polymerase II
N=1-376 P transcription by RNA polymerase II
N=1-376 P transcription initiation from RNA polymerase II promoter
O=1-109 C cell junction
O=1-109 C nucleoplasm
O=1-109 C transcription factor TFIIA complex
O=1-109 C transcription factor TFIID complex
O=1-109 F protein heterodimerization activity
O=1-109 F protein homodimerization activity
O=1-109 F RNA polymerase II general transcription initiation factor activity
O=1-109 F RNA polymerase II repressing transcription factor binding
O=1-109 F TBP-class protein binding
O=1-109 F transcription coactivator activity
O=1-109 F transcription factor binding
O=1-109 P positive regulation of DNA-binding transcription factor activity
O=1-109 P positive regulation of transcription by RNA polymerase II
O=1-109 P RNA polymerase II preinitiation complex assembly
O=1-109 P snRNA transcription by RNA polymerase II
O=1-109 P transcription by RNA polymerase II
O=1-109 P transcription initiation from RNA polymerase II promoter
O=1-109 P viral process
P=1-339 C cytoplasm
P=1-339 C female pronucleus
P=1-339 C male pronucleus
P=1-339 C nuclear chromatin
P=1-339 C nuclear euchromatin
P=1-339 C nucleoplasm
P=1-339 C nucleus
P=1-339 C protein-containing complex
P=1-339 C transcription factor TFIIA complex
P=1-339 C transcription factor TFIID complex
P=1-339 C transcription factor TFIIIB complex
P=1-339 C transcription preinitiation complex
P=1-339 C transcription regulator complex
P=1-339 F aryl hydrocarbon receptor binding
P=1-339 F core promoter sequence-specific DNA binding
P=1-339 F DNA-binding transcription factor activity
P=1-339 F enzyme binding
P=1-339 F repressing transcription factor binding
P=1-339 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
P=1-339 F RNA polymerase II core promoter sequence-specific DNA binding
P=1-339 F RNA polymerase II general transcription initiation factor activity
P=1-339 F RNA polymerase II general transcription initiation factor binding
P=1-339 F RNA polymerase II repressing transcription factor binding
P=1-339 F RNA polymerase III general transcription initiation factor activity
P=1-339 F RNA polymerase III transcription regulatory region sequence-specific DNA binding
P=1-339 F TFIIB-class transcription factor binding
P=1-339 F transcription factor binding
P=1-339 F transcription regulatory region sequence-specific DNA binding
P=1-339 P positive regulation of gene expression, epigenetic
P=1-339 P positive regulation of transcription, DNA-templated
P=1-339 P regulation of signal transduction by p53 class mediator
P=1-339 P RNA polymerase II preinitiation complex assembly
P=1-339 P RNA polymerase III preinitiation complex assembly
P=1-339 P snRNA transcription by RNA polymerase II
P=1-339 P spermatogenesis
P=1-339 P termination of RNA polymerase I transcription
P=1-339 P transcription by RNA polymerase II
P=1-339 P transcription by RNA polymerase III
P=1-339 P transcription elongation from RNA polymerase I promoter
P=1-339 P transcription initiation from RNA polymerase I promoter
P=1-339 P transcription initiation from RNA polymerase II promoter
P=1-339 P viral process
Q=1-439 C cytosol
Q=1-439 C nucleoplasm
Q=1-439 C nucleus
Q=1-439 C transcription factor TFIID complex
Q=1-439 C transcription factor TFIIE complex
Q=1-439 C transcription preinitiation complex
Q=1-439 F metal ion binding
Q=1-439 F RNA polymerase II complex binding
Q=1-439 F RNA polymerase II general transcription initiation factor activity
Q=1-439 F TFIIH-class transcription factor complex binding
Q=1-439 P regulation of transcription by RNA polymerase II
Q=1-439 P snRNA transcription by RNA polymerase II
Q=1-439 P transcription by RNA polymerase II
Q=1-439 P transcription initiation from RNA polymerase II promoter
Q=1-439 P transcription open complex formation at RNA polymerase II promoter
Q=1-439 P viral process
R=1-291 C cytosol
R=1-291 C nuclear speck
R=1-291 C nucleoplasm
R=1-291 C transcription factor TFIID complex
R=1-291 C transcription factor TFIIE complex
R=1-291 F DNA binding
R=1-291 F RNA binding
R=1-291 F RNA polymerase II general transcription initiation factor activity
R=1-291 P snRNA transcription by RNA polymerase II
R=1-291 P transcription by RNA polymerase II
R=1-291 P transcription initiation from RNA polymerase II promoter
S=1-517 C cell junction
S=1-517 C intracellular membrane-bounded organelle
S=1-517 C nucleoplasm
S=1-517 C nucleus
S=1-517 C protein-containing complex
S=1-517 C transcription factor TFIID complex
S=1-517 C transcription factor TFIIF complex
S=1-517 F DNA binding
S=1-517 F phosphatase activator activity
S=1-517 F promoter-specific chromatin binding
S=1-517 F protein domain specific binding
S=1-517 F protein phosphatase binding
S=1-517 F RNA binding
S=1-517 F RNA polymerase II general transcription initiation factor activity
S=1-517 F TFIIF-class transcription factor complex binding
S=1-517 F transcription factor binding
S=1-517 P 7-methylguanosine mRNA capping
S=1-517 P fibroblast growth factor receptor signaling pathway
S=1-517 P mRNA splicing, via spliceosome
S=1-517 P negative regulation of protein binding
S=1-517 P positive regulation of transcription by RNA polymerase II
S=1-517 P positive regulation of transcription elongation from RNA polymerase II promoter
S=1-517 P positive regulation of viral transcription
S=1-517 P response to virus
S=1-517 P RNA metabolic process
S=1-517 P snRNA transcription by RNA polymerase II
S=1-517 P transcription by RNA polymerase II
S=1-517 P transcription elongation from RNA polymerase II promoter
S=1-517 P transcription initiation from RNA polymerase II promoter
T=1-249 C microtubule cytoskeleton
T=1-249 C nucleoplasm
T=1-249 C nucleus
T=1-249 C transcription factor TFIIF complex
T=1-249 C transcription preinitiation complex
T=1-249 F ATP binding
T=1-249 F DNA binding
T=1-249 F DNA helicase activity
T=1-249 F RNA polymerase II general transcription initiation factor activity
T=1-249 P 7-methylguanosine mRNA capping
T=1-249 P fibroblast growth factor receptor signaling pathway
T=1-249 P mRNA splicing, via spliceosome
T=1-249 P positive regulation of transcription elongation from RNA polymerase II promoter
T=1-249 P positive regulation of transcription initiation from RNA polymerase II promoter
T=1-249 P positive regulation of viral transcription
T=1-249 P RNA metabolic process
T=1-249 P snRNA transcription by RNA polymerase II
T=1-249 P transcription by RNA polymerase II
T=1-249 P transcription elongation from RNA polymerase II promoter
T=1-249 P transcription initiation from RNA polymerase II promoter
U=1-301 C nucleolus
U=1-301 C nucleoplasm
U=1-301 C transcription factor TFIID complex
U=1-301 F DNA binding
U=1-301 F zinc ion binding
U=1-301 P positive regulation of exoribonuclease activity
U=1-301 P positive regulation of transcription by RNA polymerase II
U=1-301 P transcription by RNA polymerase II
U=1-301 P transcription elongation from RNA polymerase II promoter
U=1-301 P transcription-coupled nucleotide-excision repair
V=1-782 C nucleoplasm
V=1-782 C nucleotide-excision repair factor 3 complex
V=1-782 C nucleus
V=1-782 C transcription factor TFIID complex
V=1-782 C transcription factor TFIIH core complex
V=1-782 C transcription factor TFIIH holo complex
V=1-782 C transcription preinitiation complex
V=1-782 F 3'-5' DNA helicase activity
V=1-782 F ATP binding
V=1-782 F ATPase activity
V=1-782 F damaged DNA binding
V=1-782 F DNA binding
V=1-782 F DNA helicase activity
V=1-782 F helicase activity
V=1-782 F promoter-specific chromatin binding
V=1-782 F protein C-terminus binding
V=1-782 F protein N-terminus binding
V=1-782 F transcription factor binding
V=1-782 P 7-methylguanosine mRNA capping
V=1-782 P apoptotic process
V=1-782 P DNA repair
V=1-782 P DNA topological change
V=1-782 P embryonic organ development
V=1-782 P global genome nucleotide-excision repair
V=1-782 P hair cell differentiation
V=1-782 P nucleotide-excision repair
V=1-782 P nucleotide-excision repair, DNA duplex unwinding
V=1-782 P nucleotide-excision repair, DNA incision
V=1-782 P nucleotide-excision repair, DNA incision, 3'-to lesion
V=1-782 P nucleotide-excision repair, DNA incision, 5'-to lesion
V=1-782 P nucleotide-excision repair, preincision complex assembly
V=1-782 P nucleotide-excision repair, preincision complex stabilization
V=1-782 P positive regulation of apoptotic process
V=1-782 P protein localization
V=1-782 P protein phosphorylation
V=1-782 P regulation of mitotic cell cycle phase transition
V=1-782 P response to hypoxia
V=1-782 P response to oxidative stress
V=1-782 P response to UV
V=1-782 P termination of RNA polymerase I transcription
V=1-782 P transcription by RNA polymerase II
V=1-782 P transcription elongation from RNA polymerase I promoter
V=1-782 P transcription elongation from RNA polymerase II promoter
V=1-782 P transcription initiation from RNA polymerase I promoter
V=1-782 P transcription initiation from RNA polymerase II promoter
V=1-782 P transcription-coupled nucleotide-excision repair
V=1-782 P UV protection
V=1-782 P viral process
W=1-760 C CAK-ERCC2 complex
W=1-760 C cytoplasm
W=1-760 C cytosol
W=1-760 C MMXD complex
W=1-760 C nucleoplasm
W=1-760 C nucleus
W=1-760 C spindle
W=1-760 C transcription factor TFIID complex
W=1-760 C transcription factor TFIIH core complex
W=1-760 C transcription factor TFIIH holo complex
W=1-760 F 4 iron, 4 sulfur cluster binding
W=1-760 F 5'-3' DNA helicase activity
W=1-760 F ATP binding
W=1-760 F damaged DNA binding
W=1-760 F DNA helicase activity
W=1-760 F metal ion binding
W=1-760 F protein C-terminus binding
W=1-760 F protein N-terminus binding
W=1-760 F protein-macromolecule adaptor activity
W=1-760 P 7-methylguanosine mRNA capping
W=1-760 P aging
W=1-760 P apoptotic process
W=1-760 P bone mineralization
W=1-760 P cell population proliferation
W=1-760 P central nervous system myelin formation
W=1-760 P chromosome segregation
W=1-760 P embryonic cleavage
W=1-760 P embryonic organ development
W=1-760 P erythrocyte maturation
W=1-760 P extracellular matrix organization
W=1-760 P global genome nucleotide-excision repair
W=1-760 P hair cell differentiation
W=1-760 P hair follicle maturation
W=1-760 P hematopoietic stem cell differentiation
W=1-760 P in utero embryonic development
W=1-760 P maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
W=1-760 P multicellular organism growth
W=1-760 P nucleotide-excision repair
W=1-760 P nucleotide-excision repair, DNA duplex unwinding
W=1-760 P nucleotide-excision repair, DNA incision
W=1-760 P nucleotide-excision repair, DNA incision, 3'-to lesion
W=1-760 P nucleotide-excision repair, DNA incision, 5'-to lesion
W=1-760 P nucleotide-excision repair, preincision complex assembly
W=1-760 P nucleotide-excision repair, preincision complex stabilization
W=1-760 P positive regulation of DNA binding
W=1-760 P positive regulation of mitotic recombination
W=1-760 P positive regulation of transcription, DNA-templated
W=1-760 P post-embryonic development
W=1-760 P protein phosphorylation
W=1-760 P regulation of mitotic cell cycle phase transition
W=1-760 P regulation of mitotic recombination
W=1-760 P response to hypoxia
W=1-760 P response to oxidative stress
W=1-760 P response to UV
W=1-760 P spinal cord development
W=1-760 P termination of RNA polymerase I transcription
W=1-760 P transcription by RNA polymerase II
W=1-760 P transcription elongation from RNA polymerase I promoter
W=1-760 P transcription elongation from RNA polymerase II promoter
W=1-760 P transcription initiation from RNA polymerase I promoter
W=1-760 P transcription initiation from RNA polymerase II promoter
W=1-760 P transcription-coupled nucleotide-excision repair
W=1-760 P UV protection
W=1-760 P viral process
Sequences
Download file with secondary structure created by Stride  
5iy7.pdb1.pdb:   [ download sequences in FASTA format ]
X (dna): 
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Y (dna): 
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0 (protein): 
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1 (protein): 
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2 (protein): 
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3 (protein): 
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A (protein): 
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B (protein): 
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C (protein): 
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D (protein): 
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E (protein): 
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F (protein): 
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G (protein): 
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H (protein): 
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I (protein): 
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J (protein): 
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K (protein): 
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L (protein): 
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M (protein): 
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N (protein): 
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O (protein): 
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P (protein): 
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Q (protein): 
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R (protein): 
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S (protein): 
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T (protein): 
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U (protein): 
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V (protein): 
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W (protein): 
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