General information
PDB ID 5MEZ
Title CRYSTAL STRUCTURE OF SMAD4-MH1 BOUND TO THE GGCT SITE.
PDB header TRANSCRIPTION
Date 2016-11-16
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.98
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb5mez.pdb AB DE 0
Biounits:
5mez.pdb1.pdb AB DE 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
MH1 Domain Q13485_36-137 3.1e-41 1 CL0263 A 36 137 DE  H-Bb S-Bb S-Mj L-Bb L-Mj 
MH1 Domain Q13485_36-137 6.5e-41 1 CL0263 B 36 136   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/B=10-140 C activin responsive factor complex
A/B=10-140 C centrosome
A/B=10-140 C cytoplasm
A/B=10-140 C cytosol
A/B=10-140 C nuclear chromatin
A/B=10-140 C nucleoplasm
A/B=10-140 C nucleus
A/B=10-140 C SMAD protein complex
A/B=10-140 C transcription regulator complex
A/B=10-140 F chromatin binding
A/B=10-140 F collagen binding
A/B=10-140 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/B=10-140 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/B=10-140 F I-SMAD binding
A/B=10-140 F identical protein binding
A/B=10-140 F metal ion binding
A/B=10-140 F protein homodimerization activity
A/B=10-140 F R-SMAD binding
A/B=10-140 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/B=10-140 F RNA polymerase II transcription factor binding
A/B=10-140 F sulfate binding
A/B=10-140 F transcription coactivator binding
A/B=10-140 F transcription regulatory region sequence-specific DNA binding
A/B=10-140 P atrioventricular canal development
A/B=10-140 P atrioventricular valve formation
A/B=10-140 P axon guidance
A/B=10-140 P BMP signaling pathway
A/B=10-140 P brainstem development
A/B=10-140 P branching involved in ureteric bud morphogenesis
A/B=10-140 P cell population proliferation
A/B=10-140 P cellular iron ion homeostasis
A/B=10-140 P cellular response to BMP stimulus
A/B=10-140 P developmental growth
A/B=10-140 P embryonic digit morphogenesis
A/B=10-140 P endocardial cell differentiation
A/B=10-140 P endoderm development
A/B=10-140 P endothelial cell activation
A/B=10-140 P epithelial to mesenchymal transition involved in endocardial cushion formation
A/B=10-140 P female gonad morphogenesis
A/B=10-140 P formation of anatomical boundary
A/B=10-140 P gastrulation with mouth forming second
A/B=10-140 P in utero embryonic development
A/B=10-140 P interleukin-6-mediated signaling pathway
A/B=10-140 P intracellular signal transduction
A/B=10-140 P left ventricular cardiac muscle tissue morphogenesis
A/B=10-140 P mesoderm development
A/B=10-140 P metanephric mesenchyme morphogenesis
A/B=10-140 P negative regulation of cardiac muscle hypertrophy
A/B=10-140 P negative regulation of cardiac myofibril assembly
A/B=10-140 P negative regulation of cell death
A/B=10-140 P negative regulation of cell growth
A/B=10-140 P negative regulation of cell population proliferation
A/B=10-140 P negative regulation of ERK1 and ERK2 cascade
A/B=10-140 P negative regulation of transcription by RNA polymerase II
A/B=10-140 P negative regulation of transcription, DNA-templated
A/B=10-140 P nephrogenic mesenchyme morphogenesis
A/B=10-140 P neural crest cell differentiation
A/B=10-140 P neuron fate commitment
A/B=10-140 P outflow tract septum morphogenesis
A/B=10-140 P ovarian follicle development
A/B=10-140 P positive regulation of BMP signaling pathway
A/B=10-140 P positive regulation of cell proliferation involved in heart valve morphogenesis
A/B=10-140 P positive regulation of epithelial to mesenchymal transition
A/B=10-140 P positive regulation of follicle-stimulating hormone secretion
A/B=10-140 P positive regulation of histone H3-K4 methylation
A/B=10-140 P positive regulation of histone H3-K9 acetylation
A/B=10-140 P positive regulation of luteinizing hormone secretion
A/B=10-140 P positive regulation of pathway-restricted SMAD protein phosphorylation
A/B=10-140 P positive regulation of pri-miRNA transcription by RNA polymerase II
A/B=10-140 P positive regulation of SMAD protein signal transduction
A/B=10-140 P positive regulation of transcription by RNA polymerase II
A/B=10-140 P positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
A/B=10-140 P positive regulation of transcription, DNA-templated
A/B=10-140 P positive regulation of transforming growth factor beta receptor signaling pathway
A/B=10-140 P protein deubiquitination
A/B=10-140 P regulation of binding
A/B=10-140 P regulation of hair follicle development
A/B=10-140 P regulation of transforming growth factor beta receptor signaling pathway
A/B=10-140 P regulation of transforming growth factor beta2 production
A/B=10-140 P response to hypoxia
A/B=10-140 P response to transforming growth factor beta
A/B=10-140 P sebaceous gland development
A/B=10-140 P secondary palate development
A/B=10-140 P seminiferous tubule development
A/B=10-140 P single fertilization
A/B=10-140 P SMAD protein complex assembly
A/B=10-140 P SMAD protein signal transduction
A/B=10-140 P somatic stem cell population maintenance
A/B=10-140 P somite rostral/caudal axis specification
A/B=10-140 P spermatogenesis
A/B=10-140 P transforming growth factor beta receptor signaling pathway
A/B=10-140 P uterus development
A/B=10-140 P ventricular septum morphogenesis
Sequences
Download file with secondary structure created by Stride  
5mez.pdb1.pdb:   [ download sequences in FASTA format ]
D (dna): 
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E (dna): 
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A (protein): 
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B (protein): 
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