General information
PDB ID 6MZM
Title HUMAN TFIID BOUND TO PROMOTER DNA AND TFIIA
PDB header TRANSCRIPTION/DNA
Date 2018-11-05
Experimental method ELECTRON MICROSCOPY
Resolution (A) 7.5
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb6mzm.pdb ABDGHIJKLORTWXZ UV 0
Biounits:
6mzm.pdb1.pdb ABDGHIJKLORTWXZ UV 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Peptidase_M1_N Domain Q6P1X5_5-226 0.00015 0 CL0672 B 23 244   
TAF Domain P49848_11-76 3.9e-31 1 CL0012 I 11 76   
Bromo_TP Domain Q7Z7C8_29-106 2.6e-30 1 CL0012 K 29 106   
TFIID-31kDa Domain Q16594_13-116 1e-40 1 CL0012 L 13 113   
TFIID_20kDa Domain Q16514_59-126 5.8e-37 1 CL0012 R 59 126   
TBP Domain P20226_162-244 6.2e-33 1 CL0407 T 162 244 UV  S-Bb S-Mn L-Bb L-Mj L-Mn 
TBP Domain P20226_252-335 9.9e-32 1 CL0407 T 252 335 UV  S-Bb S-Mj S-Mn L-Bb 
TFIIA_gamma_N Domain P52657_3-48 8.6e-23 1 No_clan X 3 48   
TFIIA_gamma_C Domain P52657_59-99 6.8e-21 1 No_clan X 59 99   
DUF3591 Family P21675_588-1028 9e-148 1 CL0662 A 588 1028 UV  H-Bb L-Bb L-Mn 
TAF4 Family O00268_870-1007 9.6e-34 1 CL0012 D 870 1007   
TFIID_NTD2 Family Q15542_210-337 3e-41 1 No_clan G 210 337   
TAFII55_N Family Q15545_12-154 8.9e-45 1 CL0662 J 12 154   
TFIID_30kDa Family Q12962_128-177 1.7e-27 1 CL0012 O 128 177   
TFIIA Family P52655_330-376 2.6e-32 1 No_clan W 50 376 UV  S-Bb L-Bb 
TFIIA Family P52655_13-51 1.6e-17 1 No_clan W 13 332   
WD40 Repeat Q15542_533-571 7e-11 1 CL0186 G 659 697   
WD40 Repeat Q15542_533-571 8.1e-11 1 CL0186 G 617 655   
WD40 Repeat Q15542_533-571 1.2e-09 1 CL0186 G 701 739   
WD40 Repeat Q15542_461-498 5.4e-08 1 CL0186 G 534 571   
WD40 Repeat Q15542_461-498 5.4e-05 1 CL0186 G 575 612   
TAF6_C Repeat P49848_308-397 4.8e-31 1 CL0020 H 308 397   
TAF6_C Repeat P49848_308-397 8.2e-31 1 CL0020 I 308 397   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A=588-1083 C MLL1 complex
A=588-1083 C nuclear chromatin
A=588-1083 C nucleoplasm
A=588-1083 C nucleus
A=588-1083 C transcription factor TFIID complex
A=588-1083 C transcription regulator complex
A=588-1083 F ATP binding
A=588-1083 F DNA-binding transcription factor inhibitor activity
A=588-1083 F histone acetyltransferase activity
A=588-1083 F kinase activity
A=588-1083 F lysine-acetylated histone binding
A=588-1083 F nuclear hormone receptor binding
A=588-1083 F p53 binding
A=588-1083 F protein heterodimerization activity
A=588-1083 F protein kinase activity
A=588-1083 F protein serine/threonine kinase activity
A=588-1083 F RNA polymerase I general transcription initiation factor activity
A=588-1083 F RNA polymerase II core promoter sequence-specific DNA binding
A=588-1083 F RNA polymerase II general transcription initiation factor activity
A=588-1083 F RNA polymerase II-specific DNA-binding transcription factor binding
A=588-1083 F sequence-specific DNA binding
A=588-1083 F TBP-class protein binding
A=588-1083 F transcription factor binding
A=588-1083 F ubiquitin conjugating enzyme activity
A=588-1083 P cell cycle
A=588-1083 P cellular response to ATP
A=588-1083 P cellular response to DNA damage stimulus
A=588-1083 P cellular response to UV
A=588-1083 P midbrain development
A=588-1083 P negative regulation of DNA-binding transcription factor activity
A=588-1083 P negative regulation of gene expression
A=588-1083 P negative regulation of protein autoubiquitination
A=588-1083 P negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
A=588-1083 P negative regulation of transcription by RNA polymerase II
A=588-1083 P negative regulation of ubiquitin-dependent protein catabolic process
A=588-1083 P peptidyl-serine phosphorylation
A=588-1083 P peptidyl-threonine phosphorylation
A=588-1083 P positive regulation of androgen receptor activity
A=588-1083 P positive regulation of proteasomal ubiquitin-dependent protein catabolic process
A=588-1083 P positive regulation of protein binding
A=588-1083 P positive regulation of transcription by RNA polymerase II
A=588-1083 P protein autophosphorylation
A=588-1083 P protein phosphorylation
A=588-1083 P protein polyubiquitination
A=588-1083 P protein stabilization
A=588-1083 P regulation of cell cycle G1/S phase transition
A=588-1083 P regulation of signal transduction by p53 class mediator
A=588-1083 P RNA polymerase II preinitiation complex assembly
A=588-1083 P transcription by RNA polymerase II
A=588-1083 P transcription factor catabolic process
A=588-1083 P transcription initiation from RNA polymerase I promoter
A=588-1083 P transcription initiation from RNA polymerase II promoter
A=588-1083 P ubiquitin-dependent protein catabolic process
A=588-1083 P viral process
B=1-1199 C nucleoplasm
B=1-1199 C transcription factor TFIID complex
B=1-1199 C transcription factor TFTC complex
B=1-1199 F chromatin binding
B=1-1199 F RNA polymerase II general transcription initiation factor activity
B=1-1199 F transcription regulatory region sequence-specific DNA binding
B=1-1199 P G2/M transition of mitotic cell cycle
B=1-1199 P positive regulation of transcription by RNA polymerase II
B=1-1199 P regulation of signal transduction by p53 class mediator
B=1-1199 P response to organic cyclic compound
B=1-1199 P transcription by RNA polymerase II
B=1-1199 P transcription initiation from RNA polymerase II promoter
D=61-1085 C cytosol
D=61-1085 C MLL1 complex
D=61-1085 C nuclear chromatin
D=61-1085 C nucleoplasm
D=61-1085 C protein-containing complex
D=61-1085 C transcription factor TFIID complex
D=61-1085 C transcription factor TFTC complex
D=61-1085 F aryl hydrocarbon receptor binding
D=61-1085 F DNA binding
D=61-1085 F protein heterodimerization activity
D=61-1085 F transcription factor binding
D=61-1085 P DNA-templated transcription, initiation
D=61-1085 P ovarian follicle development
D=61-1085 P positive regulation of transcription by RNA polymerase II
D=61-1085 P regulation of signal transduction by p53 class mediator
D=61-1085 P transcription by RNA polymerase II
D=61-1085 P transcription initiation from RNA polymerase II promoter
D=61-1085 P viral process
G=1-800 C actin cytoskeleton
G=1-800 C nuclear chromatin
G=1-800 C nucleoplasm
G=1-800 C nucleus
G=1-800 C transcription factor TFIID complex
G=1-800 C transcription factor TFTC complex
G=1-800 F identical protein binding
G=1-800 F promoter-specific chromatin binding
G=1-800 F RNA polymerase II general transcription initiation factor activity
G=1-800 F transcription coactivator activity
G=1-800 P DNA-templated transcription, initiation
G=1-800 P histone H3 acetylation
G=1-800 P positive regulation of transcription by RNA polymerase II
G=1-800 P regulation of signal transduction by p53 class mediator
G=1-800 P snRNA transcription by RNA polymerase II
G=1-800 P transcription by RNA polymerase II
G=1-800 P transcription initiation from RNA polymerase II promoter
G=1-800 P viral process
H/I=1-677 C cytosol
H/I=1-677 C MLL1 complex
H/I=1-677 C nucleoplasm
H/I=1-677 C nucleus
H/I=1-677 C protein-containing complex
H/I=1-677 C SAGA complex
H/I=1-677 C SLIK (SAGA-like) complex
H/I=1-677 C transcription factor TFIID complex
H/I=1-677 C transcription factor TFTC complex
H/I=1-677 F aryl hydrocarbon receptor binding
H/I=1-677 F DNA binding
H/I=1-677 F protein heterodimerization activity
H/I=1-677 F RNA polymerase II general transcription initiation factor activity
H/I=1-677 F transcription coactivator activity
H/I=1-677 P apoptotic process
H/I=1-677 P chromatin organization
H/I=1-677 P DNA-templated transcription, initiation
H/I=1-677 P negative regulation of cell cycle
H/I=1-677 P negative regulation of cell population proliferation
H/I=1-677 P positive regulation of apoptotic process
H/I=1-677 P positive regulation of intrinsic apoptotic signaling pathway
H/I=1-677 P positive regulation of transcription initiation from RNA polymerase II promoter
H/I=1-677 P regulation of signal transduction by p53 class mediator
H/I=1-677 P RNA polymerase II preinitiation complex assembly
H/I=1-677 P snRNA transcription by RNA polymerase II
H/I=1-677 P transcription by RNA polymerase II
H/I=1-677 P transcription initiation from RNA polymerase II promoter
J=1-349 C Golgi apparatus
J=1-349 C MLL1 complex
J=1-349 C nucleoplasm
J=1-349 C transcription factor TFIID complex
J=1-349 C transcription factor TFTC complex
J=1-349 C transcription regulator complex
J=1-349 F histone acetyltransferase binding
J=1-349 F P-TEFb complex binding
J=1-349 F protein heterodimerization activity
J=1-349 F RNA polymerase II general transcription initiation factor activity
J=1-349 F TFIIH-class transcription factor complex binding
J=1-349 F thyroid hormone receptor binding
J=1-349 F transcription coactivator activity
J=1-349 F transcription factor binding
J=1-349 F transcription regulatory region sequence-specific DNA binding
J=1-349 F vitamin D receptor binding
J=1-349 P DNA-templated transcription, initiation
J=1-349 P intracellular estrogen receptor signaling pathway
J=1-349 P negative regulation of histone acetylation
J=1-349 P negative regulation of histone H4 acetylation
J=1-349 P negative regulation of MHC class I biosynthetic process
J=1-349 P negative regulation of MHC class II biosynthetic process
J=1-349 P negative regulation of protein kinase activity
J=1-349 P negative regulation of transcription by RNA polymerase II
J=1-349 P negative regulation of transcription, DNA-templated
J=1-349 P positive regulation of transcription by RNA polymerase II
J=1-349 P regulation of signal transduction by p53 class mediator
J=1-349 P regulation of transcription by RNA polymerase II
J=1-349 P RNA polymerase II preinitiation complex assembly
J=1-349 P spermine transport
J=1-349 P transcription by RNA polymerase II
J=1-349 P transcription initiation from RNA polymerase II promoter
K=1-310 C nucleoplasm
K=1-310 C nucleus
K=1-310 C perinuclear region of cytoplasm
K=1-310 C transcription factor TFIID complex
K=1-310 F protein heterodimerization activity
K=1-310 F RNA polymerase II general transcription initiation factor activity
K=1-310 P cell differentiation
K=1-310 P DNA-templated transcription open complex formation
K=1-310 P inner cell mass cell proliferation
K=1-310 P maintenance of protein location in nucleus
K=1-310 P regulation of fat cell differentiation
K=1-310 P snRNA transcription by RNA polymerase II
L=1-264 C MLL1 complex
L=1-264 C nucleoplasm
L=1-264 C nucleus
L=1-264 C PCAF complex
L=1-264 C pre-snoRNP complex
L=1-264 C SAGA complex
L=1-264 C STAGA complex
L=1-264 C transcription factor TFIID complex
L=1-264 C transcription factor TFTC complex
L=1-264 F activating transcription factor binding
L=1-264 F ATPase binding
L=1-264 F C2H2 zinc finger domain binding
L=1-264 F DNA binding
L=1-264 F p53 binding
L=1-264 F protein heterodimerization activity
L=1-264 F RNA polymerase II general transcription initiation factor activity
L=1-264 F transcription coactivator activity
L=1-264 F transcription factor binding
L=1-264 F transcription regulatory region sequence-specific DNA binding
L=1-264 P box C/D snoRNP assembly
L=1-264 P cellular response to DNA damage stimulus
L=1-264 P histone H3 acetylation
L=1-264 P negative regulation of apoptotic process
L=1-264 P negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
L=1-264 P negative regulation of proteasomal ubiquitin-dependent protein catabolic process
L=1-264 P positive regulation of response to cytokine stimulus
L=1-264 P positive regulation of transcription by RNA polymerase II
L=1-264 P protein stabilization
L=1-264 P regulation of signal transduction by p53 class mediator
L=1-264 P response to interleukin-1
L=1-264 P snRNA transcription by RNA polymerase II
L=1-264 P transcription by RNA polymerase II
L=1-264 P transcription initiation from RNA polymerase II promoter
O=1-218 C cytoplasm
O=1-218 C nucleoplasm
O=1-218 C nucleus
O=1-218 C PCAF complex
O=1-218 C perinuclear region of cytoplasm
O=1-218 C STAGA complex
O=1-218 C transcription factor TFIID complex
O=1-218 C transcription factor TFTC complex
O=1-218 F DNA binding
O=1-218 F enzyme binding
O=1-218 F estrogen receptor binding
O=1-218 F identical protein binding
O=1-218 F promoter-specific chromatin binding
O=1-218 F RNA polymerase binding
O=1-218 F RNA polymerase II general transcription initiation factor activity
O=1-218 P apoptotic process
O=1-218 P cellular protein-containing complex assembly
O=1-218 P DNA-templated transcription, initiation
O=1-218 P G1/S transition of mitotic cell cycle
O=1-218 P hepatocyte differentiation
O=1-218 P histone deubiquitination
O=1-218 P histone H3 acetylation
O=1-218 P multicellular organism growth
O=1-218 P protein deubiquitination
O=1-218 P regulation of DNA binding
O=1-218 P regulation of gene expression
O=1-218 P regulation of signal transduction by p53 class mediator
O=1-218 P transcription by RNA polymerase II
O=1-218 P transcription initiation from RNA polymerase II promoter
R=1-161 C nucleoplasm
R=1-161 C nucleus
R=1-161 C PCAF complex
R=1-161 C SAGA complex
R=1-161 C SLIK (SAGA-like) complex
R=1-161 C STAGA complex
R=1-161 C transcription factor TFIID complex
R=1-161 C transcription factor TFTC complex
R=1-161 F DNA binding
R=1-161 F protein heterodimerization activity
R=1-161 F TBP-class protein binding
R=1-161 F transcription coactivator activity
R=1-161 F transcription factor binding
R=1-161 P DNA-templated transcription, initiation
R=1-161 P histone H3 acetylation
R=1-161 P positive regulation of DNA-binding transcription factor activity
R=1-161 P regulation of signal transduction by p53 class mediator
R=1-161 P RNA polymerase II preinitiation complex assembly
R=1-161 P transcription by RNA polymerase II
R=1-161 P transcription initiation from RNA polymerase II promoter
T=1-339 C cytoplasm
T=1-339 C female pronucleus
T=1-339 C male pronucleus
T=1-339 C nuclear chromatin
T=1-339 C nuclear euchromatin
T=1-339 C nucleoplasm
T=1-339 C nucleus
T=1-339 C protein-containing complex
T=1-339 C transcription factor TFIIA complex
T=1-339 C transcription factor TFIID complex
T=1-339 C transcription factor TFIIIB complex
T=1-339 C transcription preinitiation complex
T=1-339 C transcription regulator complex
T=1-339 F aryl hydrocarbon receptor binding
T=1-339 F core promoter sequence-specific DNA binding
T=1-339 F DNA-binding transcription factor activity
T=1-339 F enzyme binding
T=1-339 F repressing transcription factor binding
T=1-339 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
T=1-339 F RNA polymerase II core promoter sequence-specific DNA binding
T=1-339 F RNA polymerase II general transcription initiation factor activity
T=1-339 F RNA polymerase II general transcription initiation factor binding
T=1-339 F RNA polymerase II repressing transcription factor binding
T=1-339 F RNA polymerase III general transcription initiation factor activity
T=1-339 F RNA polymerase III transcription regulatory region sequence-specific DNA binding
T=1-339 F TFIIB-class transcription factor binding
T=1-339 F transcription factor binding
T=1-339 F transcription regulatory region sequence-specific DNA binding
T=1-339 P positive regulation of gene expression, epigenetic
T=1-339 P positive regulation of transcription, DNA-templated
T=1-339 P regulation of signal transduction by p53 class mediator
T=1-339 P RNA polymerase II preinitiation complex assembly
T=1-339 P RNA polymerase III preinitiation complex assembly
T=1-339 P snRNA transcription by RNA polymerase II
T=1-339 P spermatogenesis
T=1-339 P termination of RNA polymerase I transcription
T=1-339 P transcription by RNA polymerase II
T=1-339 P transcription by RNA polymerase III
T=1-339 P transcription elongation from RNA polymerase I promoter
T=1-339 P transcription initiation from RNA polymerase I promoter
T=1-339 P transcription initiation from RNA polymerase II promoter
T=1-339 P viral process
W=9-376 C cytosol
W=9-376 C nucleoplasm
W=9-376 C transcription factor TFIIA complex
W=9-376 C transcription factor TFIID complex
W=9-376 C transcription preinitiation complex
W=9-376 F DNA binding
W=9-376 F protein heterodimerization activity
W=9-376 F RNA polymerase II core promoter sequence-specific DNA binding
W=9-376 F RNA polymerase II general transcription initiation factor activity
W=9-376 F RNA polymerase II repressing transcription factor binding
W=9-376 F TBP-class protein binding
W=9-376 F transcription factor binding
W=9-376 P snRNA transcription by RNA polymerase II
W=9-376 P transcription by RNA polymerase II
W=9-376 P transcription initiation from RNA polymerase II promoter
X=3-99 C cell junction
X=3-99 C nucleoplasm
X=3-99 C transcription factor TFIIA complex
X=3-99 C transcription factor TFIID complex
X=3-99 F protein heterodimerization activity
X=3-99 F protein homodimerization activity
X=3-99 F RNA polymerase II general transcription initiation factor activity
X=3-99 F RNA polymerase II repressing transcription factor binding
X=3-99 F TBP-class protein binding
X=3-99 F transcription coactivator activity
X=3-99 F transcription factor binding
X=3-99 P positive regulation of DNA-binding transcription factor activity
X=3-99 P positive regulation of transcription by RNA polymerase II
X=3-99 P RNA polymerase II preinitiation complex assembly
X=3-99 P snRNA transcription by RNA polymerase II
X=3-99 P transcription by RNA polymerase II
X=3-99 P transcription initiation from RNA polymerase II promoter
X=3-99 P viral process
Sequences
Download file with secondary structure created by Stride  
6mzm.pdb1.pdb:   [ download sequences in FASTA format ]
U (dna): 
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V (dna): 
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A (protein): 
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B (protein): 
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D (protein): 
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G (protein): 
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H (protein): 
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I (protein): 
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J (protein): 
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K (protein): 
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L (protein): 
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O (protein): 
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R (protein): 
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T (protein): 
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W (protein): 
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X (protein): 
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Z (protein): 
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