General information
PDB ID 6PAX
Title CRYSTAL STRUCTURE OF THE HUMAN PAX-6 PAIRED DOMAIN-DNA COMPLEX REVEALS A GENERAL MODEL FOR PAX PROTEIN-DNA INTERACTIONS
PDB header GENE REGULATION/DNA
Date 1999-04-22
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.5
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb6pax.pdb A BC 0
Biounits:
6pax.pdb1.pdb A BC 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
PAX Domain P26367_4-128 8.3e-73 1 CL0123 A 1 125 BC  H-Bb H-Mj S-Bb L-Bb L-Mj L-Mn 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: Homeodomain-like
      Family: Paired domain
Pax-6 A 1 68 BC  H-Bb H-Mj S-Bb L-Bb L-Mj L-Mn 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: Homeodomain-like
      Family: Paired domain
Pax-6 A 69 133 BC  H-Bb H-Mj L-Bb L-Mn 
GO terms
Protein chains: GO type: GO description:
A=4-136 C cytoplasm
A=4-136 C cytosol
A=4-136 C nuclear chromatin
A=4-136 C nucleoplasm
A=4-136 C nucleus
A=4-136 F chromatin binding
A=4-136 F co-SMAD binding
A=4-136 F DNA binding
A=4-136 F DNA-binding transcription activator activity, RNA polymerase II-specific
A=4-136 F DNA-binding transcription factor activity
A=4-136 F DNA-binding transcription factor activity, RNA polymerase II-specific
A=4-136 F DNA-binding transcription repressor activity, RNA polymerase II-specific
A=4-136 F histone acetyltransferase binding
A=4-136 F HMG box domain binding
A=4-136 F protein kinase binding
A=4-136 F R-SMAD binding
A=4-136 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A=4-136 F RNA polymerase II core promoter sequence-specific DNA binding
A=4-136 F sequence-specific double-stranded DNA binding
A=4-136 F transcription factor binding
A=4-136 F ubiquitin protein ligase binding
A=4-136 P animal organ morphogenesis
A=4-136 P astrocyte differentiation
A=4-136 P axon guidance
A=4-136 P blood vessel development
A=4-136 P cell fate determination
A=4-136 P cellular response to leukemia inhibitory factor
A=4-136 P central nervous system development
A=4-136 P cerebral cortex regionalization
A=4-136 P commitment of neuronal cell to specific neuron type in forebrain
A=4-136 P cornea development in camera-type eye
A=4-136 P dorsal/ventral axis specification
A=4-136 P embryonic camera-type eye morphogenesis
A=4-136 P establishment of mitotic spindle orientation
A=4-136 P eye development
A=4-136 P eye photoreceptor cell development
A=4-136 P forebrain dorsal/ventral pattern formation
A=4-136 P forebrain-midbrain boundary formation
A=4-136 P glucose homeostasis
A=4-136 P habenula development
A=4-136 P iris morphogenesis
A=4-136 P keratinocyte differentiation
A=4-136 P lacrimal gland development
A=4-136 P lens development in camera-type eye
A=4-136 P negative regulation of epithelial cell proliferation
A=4-136 P negative regulation of neural precursor cell proliferation
A=4-136 P negative regulation of neurogenesis
A=4-136 P negative regulation of neuron differentiation
A=4-136 P negative regulation of protein phosphorylation
A=4-136 P neuron fate commitment
A=4-136 P neuron migration
A=4-136 P oligodendrocyte cell fate specification
A=4-136 P pancreatic A cell development
A=4-136 P pituitary gland development
A=4-136 P positive regulation of core promoter binding
A=4-136 P positive regulation of epithelial cell differentiation
A=4-136 P positive regulation of gene expression
A=4-136 P positive regulation of neuroblast proliferation
A=4-136 P positive regulation of transcription by RNA polymerase II
A=4-136 P positive regulation of transcription, DNA-templated
A=4-136 P protein localization to organelle
A=4-136 P regulation of asymmetric cell division
A=4-136 P regulation of cell migration
A=4-136 P regulation of timing of cell differentiation
A=4-136 P regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment
A=4-136 P regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
A=4-136 P regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
A=4-136 P response to wounding
A=4-136 P retina development in camera-type eye
A=4-136 P salivary gland morphogenesis
A=4-136 P signal transduction involved in regulation of gene expression
A=4-136 P smoothened signaling pathway
A=4-136 P type B pancreatic cell differentiation
A=4-136 P visual perception
Sequences
Download file with secondary structure created by Stride  
6pax.pdb1.pdb:   [ download sequences in FASTA format ]
B (dna): 
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C (dna): 
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A (protein): 
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