General information
PDB ID 6QHD
Title LYSINE ACETYLATED AND TYROSINE PHOSPHORYLATED STAT3 IN A COMPLEX WITH DNA
PDB header TRANSCRIPTION
Date 2019-01-16
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.85
Kind dna
Organism HOMO SAPIENS, MURINE ADENOVIRUS 1
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb6qhd.pdb AB CD 0
Biounits:
6qhd.pdb1.pdb AB CD 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
STAT_bind Domain P40763_325-464 1.4e-36 1 CL0073 A 325 464 CD  H-Bb S-Bb S-Mj L-Bb 
SH2 Domain P40763_584-674 2.3e-12 1 CL0541 A 584 674   
STAT_bind Domain P40763_325-464 5.8e-36 1 CL0073 B 325 464 CD  H-Bb S-Bb S-Mj L-Bb 
SH2 Domain P40763_584-674 2.5e-13 1 CL0541 B 584 674   
STAT_alpha Family P40763_145-313 5.6e-54 1 No_clan A 145 313   
STAT_alpha Family P40763_145-313 1.7e-53 1 No_clan B 145 313   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/B=127-715 C cytoplasm
A/B=127-715 C cytosol
A/B=127-715 C glutamatergic synapse
A/B=127-715 C mitochondrial inner membrane
A/B=127-715 C nuclear chromatin
A/B=127-715 C nucleoplasm
A/B=127-715 C nucleus
A/B=127-715 C plasma membrane
A/B=127-715 C postsynaptic density
A/B=127-715 C RNA polymerase II transcription regulator complex
A/B=127-715 C transcription regulator complex
A/B=127-715 F CCR5 chemokine receptor binding
A/B=127-715 F chromatin DNA binding
A/B=127-715 F DNA binding
A/B=127-715 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/B=127-715 F DNA-binding transcription factor activity
A/B=127-715 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/B=127-715 F glucocorticoid receptor binding
A/B=127-715 F identical protein binding
A/B=127-715 F nuclear receptor activity
A/B=127-715 F primary miRNA binding
A/B=127-715 F protein dimerization activity
A/B=127-715 F protein homodimerization activity
A/B=127-715 F protein kinase binding
A/B=127-715 F protein phosphatase binding
A/B=127-715 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/B=127-715 F RNA polymerase II repressing transcription factor binding
A/B=127-715 F transcription factor binding
A/B=127-715 F transcription regulatory region sequence-specific DNA binding
A/B=127-715 P acute-phase response
A/B=127-715 P aging
A/B=127-715 P astrocyte differentiation
A/B=127-715 P cell population proliferation
A/B=127-715 P cellular response to cytokine stimulus
A/B=127-715 P cellular response to hormone stimulus
A/B=127-715 P cellular response to leptin stimulus
A/B=127-715 P cellular response to organic cyclic compound
A/B=127-715 P cytokine-mediated signaling pathway
A/B=127-715 P defense response
A/B=127-715 P eating behavior
A/B=127-715 P energy homeostasis
A/B=127-715 P eye photoreceptor cell differentiation
A/B=127-715 P glucose homeostasis
A/B=127-715 P growth hormone receptor signaling pathway
A/B=127-715 P growth hormone receptor signaling pathway via JAK-STAT
A/B=127-715 P inflammatory response
A/B=127-715 P interleukin-15-mediated signaling pathway
A/B=127-715 P interleukin-21-mediated signaling pathway
A/B=127-715 P interleukin-23-mediated signaling pathway
A/B=127-715 P interleukin-27-mediated signaling pathway
A/B=127-715 P interleukin-35-mediated signaling pathway
A/B=127-715 P interleukin-6-mediated signaling pathway
A/B=127-715 P interleukin-7-mediated signaling pathway
A/B=127-715 P interleukin-9-mediated signaling pathway
A/B=127-715 P intracellular receptor signaling pathway
A/B=127-715 P leptin-mediated signaling pathway
A/B=127-715 P mRNA transcription by RNA polymerase II
A/B=127-715 P negative regulation of autophagy
A/B=127-715 P negative regulation of cell population proliferation
A/B=127-715 P negative regulation of glycolytic process
A/B=127-715 P negative regulation of hydrogen peroxide biosynthetic process
A/B=127-715 P negative regulation of neuron death
A/B=127-715 P negative regulation of neuron migration
A/B=127-715 P negative regulation of primary miRNA processing
A/B=127-715 P negative regulation of stem cell differentiation
A/B=127-715 P negative regulation of transcription by RNA polymerase II
A/B=127-715 P nervous system development
A/B=127-715 P phosphorylation
A/B=127-715 P positive regulation of angiogenesis
A/B=127-715 P positive regulation of ATP biosynthetic process
A/B=127-715 P positive regulation of cell migration
A/B=127-715 P positive regulation of cytokine production involved in inflammatory response
A/B=127-715 P positive regulation of erythrocyte differentiation
A/B=127-715 P positive regulation of gene expression
A/B=127-715 P positive regulation of gene silencing by miRNA
A/B=127-715 P positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
A/B=127-715 P positive regulation of interleukin-1 beta production
A/B=127-715 P positive regulation of interleukin-10 production
A/B=127-715 P positive regulation of interleukin-6 production
A/B=127-715 P positive regulation of interleukin-8 production
A/B=127-715 P positive regulation of metalloendopeptidase activity
A/B=127-715 P positive regulation of miRNA mediated inhibition of translation
A/B=127-715 P positive regulation of NF-kappaB transcription factor activity
A/B=127-715 P positive regulation of Notch signaling pathway
A/B=127-715 P positive regulation of pri-miRNA transcription by RNA polymerase II
A/B=127-715 P positive regulation of transcription by RNA polymerase II
A/B=127-715 P positive regulation of transcription, DNA-templated
A/B=127-715 P positive regulation of tumor necrosis factor biosynthetic process
A/B=127-715 P positive regulation of tumor necrosis factor secretion
A/B=127-715 P positive regulation of tyrosine phosphorylation of STAT protein
A/B=127-715 P positive regulation of vascular endothelial cell proliferation
A/B=127-715 P postsynapse to nucleus signaling pathway
A/B=127-715 P protein import into nucleus
A/B=127-715 P radial glial cell differentiation
A/B=127-715 P receptor signaling pathway via JAK-STAT
A/B=127-715 P regulation of cell cycle
A/B=127-715 P regulation of cell population proliferation
A/B=127-715 P regulation of feeding behavior
A/B=127-715 P regulation of mitochondrial membrane permeability
A/B=127-715 P regulation of multicellular organism growth
A/B=127-715 P regulation of transcription by RNA polymerase II
A/B=127-715 P regulation of transcription, DNA-templated
A/B=127-715 P response to drug
A/B=127-715 P response to estradiol
A/B=127-715 P response to ethanol
A/B=127-715 P response to leptin
A/B=127-715 P response to peptide hormone
A/B=127-715 P sexual reproduction
A/B=127-715 P signal transduction
A/B=127-715 P somatic stem cell population maintenance
A/B=127-715 P T-helper 17 cell lineage commitment
A/B=127-715 P T-helper 17 type immune response
A/B=127-715 P temperature homeostasis
A/B=127-715 P viral process
Sequences
Download file with secondary structure created by Stride  
6qhd.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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A (protein): 
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B (protein): 
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