General information
PDB ID 6W8J
Title STRUCTURE OF DNMT3A (R882H) IN COMPLEX WITH CAG DNA
PDB header TRANSFERASE/DNA
Date 2020-03-20
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.45
Kind dna
Organism HOMO SAPIENS, SYNTHETIC CONSTRUCT
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb6w8j.pdb ABCD EF 0
Biounits:
6w8j.pdb1.pdb ABCD EF 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
DNA_methylase Domain Q9Y6K1_634-776 1e-12 1 CL0063 A 634 780 EF  L-Bb L-Mj L-Mn 
DNA_methylase Domain Q9Y6K1_634-776 1e-12 1 CL0063 D 634 780 EF  H-Bb L-Bb L-Mj L-Mn 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/D=628-912 C chromosome, centromeric region
A/D=628-912 C cytoplasm
A/D=628-912 C euchromatin
A/D=628-912 C nuclear heterochromatin
A/D=628-912 C nuclear matrix
A/D=628-912 C nucleoplasm
A/D=628-912 C nucleus
A/D=628-912 C XY body
A/D=628-912 F chromatin binding
A/D=628-912 F DNA (cytosine-5-)-methyltransferase activity
A/D=628-912 F DNA binding
A/D=628-912 F DNA-methyltransferase activity
A/D=628-912 F identical protein binding
A/D=628-912 F metal ion binding
A/D=628-912 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/D=628-912 F transcription corepressor activity
A/D=628-912 F transcription factor binding
A/D=628-912 P aging
A/D=628-912 P cellular response to amino acid stimulus
A/D=628-912 P cellular response to ethanol
A/D=628-912 P cellular response to hypoxia
A/D=628-912 P DNA methylation
A/D=628-912 P DNA methylation involved in embryo development
A/D=628-912 P DNA methylation involved in gamete generation
A/D=628-912 P DNA methylation-dependent heterochromatin assembly
A/D=628-912 P hepatocyte apoptotic process
A/D=628-912 P mitotic cell cycle
A/D=628-912 P negative regulation of gene expression, epigenetic
A/D=628-912 P negative regulation of transcription by RNA polymerase II
A/D=628-912 P neuron differentiation
A/D=628-912 P positive regulation of cell death
A/D=628-912 P regulation of gene expression by genetic imprinting
A/D=628-912 P response to cocaine
A/D=628-912 P response to drug
A/D=628-912 P response to estradiol
A/D=628-912 P response to ionizing radiation
A/D=628-912 P response to lead ion
A/D=628-912 P response to toxic substance
A/D=628-912 P response to vitamin A
A/D=628-912 P spermatogenesis
B/C=178-386 C cytosol
B/C=178-386 C nucleus
B/C=178-386 F enzyme activator activity
B/C=178-386 F enzyme binding
B/C=178-386 F metal ion binding
B/C=178-386 P DNA methylation
B/C=178-386 P DNA methylation involved in gamete generation
B/C=178-386 P DNA methylation on cytosine
B/C=178-386 P male meiosis I
B/C=178-386 P negative regulation of DNA methylation
B/C=178-386 P negative regulation of transcription, DNA-templated
B/C=178-386 P positive regulation of DNA methylation
B/C=178-386 P regulation of gene expression by genetic imprinting
B/C=178-386 P spermatogenesis
B/C=178-386 P stem cell differentiation
Sequences
Download file with secondary structure created by Stride  
6w8j.pdb1.pdb:   [ download sequences in FASTA format ]
E (dna): 
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F (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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D (protein): 
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