General information
PDB ID 6WC2
Title CRYSTAL STRUCTURE OF A TERNARY MEF2 CHIMERA/NKX2-5/MYOCARDIN ENHANCER DNA COMPLEX
PDB header TRANSCRIPTION
Date 2020-03-29
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.1
Kind dna
Organism HOMO SAPIENS, SYNTHETIC CONSTRUCT
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb6wc2.pdb ABCDIJMNO EFGHKL 0
Biounits:
6wc2.pdb1.pdb ABO KL 1
6wc2.pdb2.pdb CDM GH 1
6wc2.pdb3.pdb IJN EF 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
SRF-TF Domain Q02078_10-57 3.4e-25 1 No_clan A 10 57 K  L-Bb 
SRF-TF Domain Q02078_10-57 3.1e-25 1 No_clan B 10 57 L  H-Bb 
SRF-TF Domain Q02078_10-57 3.2e-25 1 No_clan C 10 57 GH  H-Bb H-Mj 
SRF-TF Domain Q02078_10-57 3.6e-25 1 No_clan D 10 57 GH  H-Bb H-Mj 
SRF-TF Domain Q02078_10-57 3.4e-25 1 No_clan I 10 57 EF  H-Bb L-Bb 
SRF-TF Domain Q02078_10-57 3.5e-25 1 No_clan J 10 57 EF  H-Bb H-Mj 
Homeodomain Domain P52952_139-194 1.3e-20 1 CL0123 M 142 195 GH  H-Bb H-Mj 
Homeodomain Domain P52952_139-194 2.9e-20 1 CL0123 N 142 194 EF  H-Bb H-Mj L-Bb L-Mn 
Homeodomain Domain P52952_139-194 2.5e-20 1 CL0123 O 143 195 KL  H-Bb H-Mj 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 C cell junction
A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 C cytosol
A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 C nuclear chromatin
A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 C nucleoplasm
A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 C nucleus
A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 C transcription regulator complex
A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 F DNA-binding transcription factor activity
A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 F histone deacetylase binding
A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 F protein dimerization activity
A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 F sequence-specific DNA binding
A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 F sequence-specific double-stranded DNA binding
A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 F transcription factor binding
A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 F transcription regulatory region sequence-specific DNA binding
A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 P cell differentiation
A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 P muscle organ development
A/B/C/D/I/J=1-8, A/B/C/D/I/J=73-91 P positive regulation of transcription by RNA polymerase II
M/N/O=137-197 C cytoplasm
M/N/O=137-197 C nuclear chromatin
M/N/O=137-197 C nucleus
M/N/O=137-197 C protein-containing complex
M/N/O=137-197 C protein-DNA complex
M/N/O=137-197 C RNA polymerase II transcription regulator complex
M/N/O=137-197 C transcription regulator complex
M/N/O=137-197 F chromatin binding
M/N/O=137-197 F DNA binding
M/N/O=137-197 F DNA-binding transcription activator activity, RNA polymerase II-specific
M/N/O=137-197 F DNA-binding transcription factor activity
M/N/O=137-197 F DNA-binding transcription factor activity, RNA polymerase II-specific
M/N/O=137-197 F protein homodimerization activity
M/N/O=137-197 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
M/N/O=137-197 F sequence-specific DNA binding
M/N/O=137-197 F sequence-specific double-stranded DNA binding
M/N/O=137-197 F transcription factor binding
M/N/O=137-197 F transcription regulatory region sequence-specific DNA binding
M/N/O=137-197 P adult heart development
M/N/O=137-197 P apoptotic process involved in heart morphogenesis
M/N/O=137-197 P atrial cardiac muscle cell development
M/N/O=137-197 P atrial septum morphogenesis
M/N/O=137-197 P atrioventricular node cell development
M/N/O=137-197 P atrioventricular node cell fate commitment
M/N/O=137-197 P bundle of His development
M/N/O=137-197 P cardiac conduction system development
M/N/O=137-197 P cardiac muscle cell differentiation
M/N/O=137-197 P cardiac muscle cell proliferation
M/N/O=137-197 P cardiac muscle contraction
M/N/O=137-197 P cardiac muscle tissue morphogenesis
M/N/O=137-197 P cardiac ventricle formation
M/N/O=137-197 P cell differentiation
M/N/O=137-197 P embryonic heart tube development
M/N/O=137-197 P embryonic heart tube left/right pattern formation
M/N/O=137-197 P heart looping
M/N/O=137-197 P heart morphogenesis
M/N/O=137-197 P heart trabecula formation
M/N/O=137-197 P hemopoiesis
M/N/O=137-197 P negative regulation of apoptotic process
M/N/O=137-197 P negative regulation of canonical Wnt signaling pathway
M/N/O=137-197 P negative regulation of cardiac muscle cell apoptotic process
M/N/O=137-197 P negative regulation of myotube differentiation
M/N/O=137-197 P negative regulation of transcription by RNA polymerase II
M/N/O=137-197 P negative regulation of transcription, DNA-templated
M/N/O=137-197 P outflow tract septum morphogenesis
M/N/O=137-197 P pharyngeal system development
M/N/O=137-197 P positive regulation of cardioblast differentiation
M/N/O=137-197 P positive regulation of cell population proliferation
M/N/O=137-197 P positive regulation of heart contraction
M/N/O=137-197 P positive regulation of neuron differentiation
M/N/O=137-197 P positive regulation of sodium ion transport
M/N/O=137-197 P positive regulation of transcription by RNA polymerase II
M/N/O=137-197 P positive regulation of transcription initiation from RNA polymerase II promoter
M/N/O=137-197 P positive regulation of transcription via serum response element binding
M/N/O=137-197 P positive regulation of transcription, DNA-templated
M/N/O=137-197 P proepicardium development
M/N/O=137-197 P pulmonary myocardium development
M/N/O=137-197 P Purkinje myocyte differentiation
M/N/O=137-197 P regulation of cardiac conduction
M/N/O=137-197 P regulation of cardiac muscle cell proliferation
M/N/O=137-197 P regulation of cardiac muscle contraction
M/N/O=137-197 P right ventricular cardiac muscle tissue morphogenesis
M/N/O=137-197 P sarcomere organization
M/N/O=137-197 P septum secundum development
M/N/O=137-197 P spleen development
M/N/O=137-197 P thyroid gland development
M/N/O=137-197 P vasculogenesis
M/N/O=137-197 P ventricular cardiac muscle cell development
M/N/O=137-197 P ventricular cardiac myofibril assembly
M/N/O=137-197 P ventricular septum morphogenesis
M/N/O=137-197 P ventricular trabecula myocardium morphogenesis
Sequences
Download file with secondary structure created by Stride  
6wc2.pdb1.pdb:   [ download sequences in FASTA format ]
K (dna): 
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L (dna): 
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A (protein): 
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B (protein): 
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O (protein): 
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6wc2.pdb2.pdb:   [ download sequences in FASTA format ]
G (dna): 
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H (dna): 
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C (protein): 
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D (protein): 
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M (protein): 
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6wc2.pdb3.pdb:   [ download sequences in FASTA format ]
E (dna): 
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F (dna): 
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I (protein): 
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J (protein): 
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N (protein): 
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