General information
PDB ID 1AU7
Title PIT-1 MUTANT/DNA COMPLEX
PDB header TRANSCRIPTION/DNA
Date 1997-09-12
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.3
Kind dna
Organism RATTUS NORVEGICUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1au7.pdb AB CD 0
Biounits:
1au7.pdb1.pdb AB CD 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Pou Domain P10037_128-197 6.1e-35 1 CL0123 A 6 75 CD  H-Bb H-Mj L-Bb L-Mj 
Homeodomain Domain P10037_216-271 1.8e-18 1 CL0123 A 76 158 CD  H-Bb H-Mj L-Bb L-Mn 
Pou Domain P10037_128-197 2.5e-34 1 CL0123 B 6 103 CD  H-Bb H-Mj L-Bb L-Mj 
Homeodomain Domain P10037_216-271 1.2e-18 1 CL0123 B 74 158 CD  H-Bb H-Mj L-Bb L-Mn 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: lambda repressor-like DNA-binding domains
    Superfamily: lambda repressor-like DNA-binding domains
      Family: POU-specific domain
Pit-1 A 5 76 CD  H-Bb H-Mj L-Bb 
Class: All alpha proteins
  Fold: lambda repressor-like DNA-binding domains
    Superfamily: lambda repressor-like DNA-binding domains
      Family: POU-specific domain
Pit-1 B 5 74 CD  H-Bb H-Mj L-Bb 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: Homeodomain-like
      Family: Homeodomain
Pit-1 POU homeodomain A 103 160 CD  H-Bb H-Mj L-Mn 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: Homeodomain-like
      Family: Homeodomain
Pit-1 POU homeodomain B 103 160 CD  H-Bb H-Mj L-Bb L-Mn 
GO terms
Protein chains: GO type: GO description:
A/B=128-273 C nucleus
A/B=128-273 F chromatin binding
A/B=128-273 F DNA binding
A/B=128-273 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/B=128-273 F DNA-binding transcription factor activity
A/B=128-273 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/B=128-273 F RNA polymerase II activating transcription factor binding
A/B=128-273 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/B=128-273 F RNA polymerase II transcription factor binding
A/B=128-273 F sequence-specific DNA binding
A/B=128-273 P adenohypophysis development
A/B=128-273 P B cell differentiation
A/B=128-273 P cell differentiation
A/B=128-273 P cell fate specification
A/B=128-273 P determination of adult lifespan
A/B=128-273 P negative regulation of transcription by RNA polymerase II
A/B=128-273 P pituitary gland development
A/B=128-273 P positive regulation of cell population proliferation
A/B=128-273 P positive regulation of inositol trisphosphate biosynthetic process
A/B=128-273 P positive regulation of multicellular organism growth
A/B=128-273 P positive regulation of transcription by RNA polymerase II
A/B=128-273 P positive regulation of transcription, DNA-templated
A/B=128-273 P regulation of insulin-like growth factor receptor signaling pathway
A/B=128-273 P regulation of transcription, DNA-templated
A/B=128-273 P somatotropin secreting cell development
A/B=128-273 P somatotropin secreting cell differentiation
Sequences
Download file with secondary structure created by Stride  
1au7.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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A (protein): 
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B (protein): 
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