General information
PDB ID 1BF5
Title TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX
PDB header GENE REGULATION/DNA
Date 1998-05-27
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.9
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1bf5.pdb A BC 0
Biounits:
1bf5.pdb1.pdb A BC 2
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
STAT_bind Domain P42224_321-458 7.3e-42 1 CL0073 A 321 458 BC   
SH2 Domain P42224_573-657 1.8e-09 1 CL0541 A 573 658   
STAT_alpha Family P42224_143-309 6.5e-48 1 No_clan A 143 309   
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: STAT DNA-binding domain
STAT-1, DNA-binding domain A 317 568 BC  L-Bb L-Mj L-Mn 
Class: All alpha proteins
  Fold: STAT-like
    Superfamily: STAT
      Family: STAT
STAT-1, coiled coil domain A 136 316 -
Class: Alpha and beta proteins (a+b)
  Fold: SH2-like
    Superfamily: SH2 domain
      Family: SH2 domain
STAT-1 A 569 710 -
GO terms
Protein chains: GO type: GO description:
A=136-710 C axon
A=136-710 C cytoplasm
A=136-710 C cytosol
A=136-710 C dendrite
A=136-710 C nuclear chromatin
A=136-710 C nucleolus
A=136-710 C nucleoplasm
A=136-710 C nucleus
A=136-710 C perinuclear region of cytoplasm
A=136-710 C protein-containing complex
A=136-710 F cadherin binding
A=136-710 F CCR5 chemokine receptor binding
A=136-710 F DNA-binding transcription activator activity, RNA polymerase II-specific
A=136-710 F DNA-binding transcription factor activity
A=136-710 F DNA-binding transcription factor activity, RNA polymerase II-specific
A=136-710 F double-stranded DNA binding
A=136-710 F enzyme binding
A=136-710 F histone acetyltransferase binding
A=136-710 F histone binding
A=136-710 F identical protein binding
A=136-710 F nuclear hormone receptor binding
A=136-710 F promoter-specific chromatin binding
A=136-710 F protein homodimerization activity
A=136-710 F protein phosphatase 2A binding
A=136-710 F repressing transcription factor binding
A=136-710 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A=136-710 F RNA polymerase II core promoter sequence-specific DNA binding
A=136-710 F tumor necrosis factor receptor binding
A=136-710 F ubiquitin-like protein ligase binding
A=136-710 P blood circulation
A=136-710 P cellular response to insulin stimulus
A=136-710 P cellular response to interferon-beta
A=136-710 P cellular response to interferon-gamma
A=136-710 P cellular response to organic cyclic compound
A=136-710 P cytokine-mediated signaling pathway
A=136-710 P defense response
A=136-710 P defense response to virus
A=136-710 P interferon-gamma-mediated signaling pathway
A=136-710 P interleukin-21-mediated signaling pathway
A=136-710 P interleukin-27-mediated signaling pathway
A=136-710 P interleukin-35-mediated signaling pathway
A=136-710 P interleukin-6-mediated signaling pathway
A=136-710 P interleukin-9-mediated signaling pathway
A=136-710 P macrophage derived foam cell differentiation
A=136-710 P metanephric mesenchymal cell differentiation
A=136-710 P metanephric mesenchymal cell proliferation involved in metanephros development
A=136-710 P negative regulation by virus of viral protein levels in host cell
A=136-710 P negative regulation of angiogenesis
A=136-710 P negative regulation of endothelial cell proliferation
A=136-710 P negative regulation of I-kappaB kinase/NF-kappaB signaling
A=136-710 P negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
A=136-710 P negative regulation of metanephric nephron tubule epithelial cell differentiation
A=136-710 P negative regulation of transcription by RNA polymerase II
A=136-710 P positive regulation of defense response to virus by host
A=136-710 P positive regulation of erythrocyte differentiation
A=136-710 P positive regulation of interferon-alpha production
A=136-710 P positive regulation of mesenchymal cell proliferation
A=136-710 P positive regulation of nitric-oxide synthase biosynthetic process
A=136-710 P positive regulation of smooth muscle cell proliferation
A=136-710 P positive regulation of transcription by RNA polymerase II
A=136-710 P positive regulation of transcription of Notch receptor target
A=136-710 P positive regulation of transcription, DNA-templated
A=136-710 P receptor signaling pathway via JAK-STAT
A=136-710 P regulation of apoptotic process
A=136-710 P regulation of cell population proliferation
A=136-710 P regulation of interferon-gamma-mediated signaling pathway
A=136-710 P regulation of transcription, DNA-templated
A=136-710 P renal tubule development
A=136-710 P response to cAMP
A=136-710 P response to cytokine
A=136-710 P response to drug
A=136-710 P response to hydrogen peroxide
A=136-710 P response to interferon-beta
A=136-710 P response to mechanical stimulus
A=136-710 P response to nutrient
A=136-710 P response to peptide hormone
A=136-710 P tumor necrosis factor-mediated signaling pathway
A=136-710 P type I interferon signaling pathway
A=136-710 P viral process
Sequences
Download file with secondary structure created by Stride  
1bf5.pdb1.pdb:   [ download sequences in FASTA format ]
A (protein): 
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