General information
PDB ID 1DSZ
Title STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1
PDB header TRANSCRIPTION/DNA
Date 2000-01-10
Experimental method X-RAY DIFFRACTION
Resolution (A) 1.7
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1dsz.pdb AB CD 0
Biounits:
1dsz.pdb1.pdb AB CD 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
zf-C4 Domain P10276_87-155 3.1e-34 1 CL0167 A 1134 1202 CD  H-Bb H-Mj S-Bb S-Mj L-Bb L-Mj 
zf-C4 Domain P19793_133-202 1.6e-33 1 CL0167 B 1233 1302 CD  H-Bb H-Mj S-Bb S-Mj L-Bb 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: Small proteins
  Fold: Glucocorticoid receptor-like (DNA-binding domain)
    Superfamily: Glucocorticoid receptor-like (DNA-binding domain)
      Family: Nuclear receptor
Retinoid X receptor (RXR-alpha) DNA-binding domain B N/A N/A CD  H-Bb H-Mj S-Bb L-Bb 
Class: Small proteins
  Fold: Glucocorticoid receptor-like (DNA-binding domain)
    Superfamily: Glucocorticoid receptor-like (DNA-binding domain)
      Family: Nuclear receptor
Retinoic acid receptor DNA-binding domain A N/A N/A CD  H-Bb H-Mj L-Bb 
GO terms
Protein chains: GO type: GO description:
A=82-167 C actin cytoskeleton
A=82-167 C cell surface
A=82-167 C cytoplasm
A=82-167 C cytosol
A=82-167 C dendrite
A=82-167 C nuclear chromatin
A=82-167 C nucleoplasm
A=82-167 C nucleus
A=82-167 C perinuclear region of cytoplasm
A=82-167 C protein-containing complex
A=82-167 C RNA polymerase II transcription regulator complex
A=82-167 F alpha-actinin binding
A=82-167 F chromatin binding
A=82-167 F chromatin DNA binding
A=82-167 F DNA-binding transcription factor activity
A=82-167 F DNA-binding transcription factor activity, RNA polymerase II-specific
A=82-167 F drug binding
A=82-167 F enzyme binding
A=82-167 F histone deacetylase binding
A=82-167 F mRNA 5'-UTR binding
A=82-167 F nuclear receptor activity
A=82-167 F protein domain specific binding
A=82-167 F protein kinase A binding
A=82-167 F protein kinase B binding
A=82-167 F retinoic acid binding
A=82-167 F retinoic acid-responsive element binding
A=82-167 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A=82-167 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
A=82-167 F sequence-specific double-stranded DNA binding
A=82-167 F signaling receptor activity
A=82-167 F signaling receptor binding
A=82-167 F transcription factor binding
A=82-167 F translation repressor activity, mRNA regulatory element binding
A=82-167 F zinc ion binding
A=82-167 P apoptotic cell clearance
A=82-167 P cell differentiation
A=82-167 P cellular response to estrogen stimulus
A=82-167 P cellular response to lipopolysaccharide
A=82-167 P chondroblast differentiation
A=82-167 P embryonic camera-type eye development
A=82-167 P face development
A=82-167 P female pregnancy
A=82-167 P germ cell development
A=82-167 P glandular epithelial cell development
A=82-167 P growth plate cartilage development
A=82-167 P hippocampus development
A=82-167 P hormone-mediated signaling pathway
A=82-167 P limb development
A=82-167 P liver development
A=82-167 P multicellular organism growth
A=82-167 P negative regulation of apoptotic process
A=82-167 P negative regulation of cartilage development
A=82-167 P negative regulation of cell population proliferation
A=82-167 P negative regulation of granulocyte differentiation
A=82-167 P negative regulation of interferon-gamma production
A=82-167 P negative regulation of transcription by RNA polymerase II
A=82-167 P negative regulation of transcription, DNA-templated
A=82-167 P negative regulation of tumor necrosis factor production
A=82-167 P neural tube closure
A=82-167 P outflow tract septum morphogenesis
A=82-167 P positive regulation of binding
A=82-167 P positive regulation of cell cycle
A=82-167 P positive regulation of cell population proliferation
A=82-167 P positive regulation of interleukin-13 production
A=82-167 P positive regulation of interleukin-4 production
A=82-167 P positive regulation of interleukin-5 production
A=82-167 P positive regulation of neuron differentiation
A=82-167 P positive regulation of T-helper 2 cell differentiation
A=82-167 P positive regulation of transcription by RNA polymerase II
A=82-167 P positive regulation of transcription, DNA-templated
A=82-167 P prostate gland development
A=82-167 P protein phosphorylation
A=82-167 P regulation of myelination
A=82-167 P regulation of synaptic plasticity
A=82-167 P response to cytokine
A=82-167 P response to estradiol
A=82-167 P response to ethanol
A=82-167 P response to retinoic acid
A=82-167 P response to vitamin A
A=82-167 P retinoic acid receptor signaling pathway
A=82-167 P Sertoli cell fate commitment
A=82-167 P signal transduction
A=82-167 P spermatogenesis
A=82-167 P trachea cartilage development
A=82-167 P transcription initiation from RNA polymerase II promoter
A=82-167 P ureteric bud development
A=82-167 P ventricular cardiac muscle cell differentiation
B=129-212 C mitochondrion
B=129-212 C nuclear chromatin
B=129-212 C nucleoplasm
B=129-212 C nucleus
B=129-212 C protein-containing complex
B=129-212 C receptor complex
B=129-212 C RNA polymerase II transcription regulator complex
B=129-212 F chromatin DNA binding
B=129-212 F DNA binding domain binding
B=129-212 F DNA-binding transcription factor activity
B=129-212 F DNA-binding transcription factor activity, RNA polymerase II-specific
B=129-212 F double-stranded DNA binding
B=129-212 F enzyme binding
B=129-212 F identical protein binding
B=129-212 F LBD domain binding
B=129-212 F nuclear receptor activity
B=129-212 F nuclear receptor binding
B=129-212 F peptide binding
B=129-212 F retinoic acid binding
B=129-212 F retinoic acid-responsive element binding
B=129-212 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
B=129-212 F RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
B=129-212 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
B=129-212 F sequence-specific DNA binding
B=129-212 F sequence-specific double-stranded DNA binding
B=129-212 F steroid hormone receptor activity
B=129-212 F transcription regulatory region sequence-specific DNA binding
B=129-212 F vitamin D receptor binding
B=129-212 F zinc ion binding
B=129-212 P anatomical structure development
B=129-212 P bile acid and bile salt transport
B=129-212 P camera-type eye development
B=129-212 P cardiac muscle cell proliferation
B=129-212 P cell differentiation
B=129-212 P cholesterol metabolic process
B=129-212 P embryo implantation
B=129-212 P in utero embryonic development
B=129-212 P maternal placenta development
B=129-212 P modulation by virus of host process
B=129-212 P negative regulation of transcription by RNA polymerase II
B=129-212 P peroxisome proliferator activated receptor signaling pathway
B=129-212 P positive regulation of transcription by RNA polymerase II
B=129-212 P positive regulation of transcription, DNA-templated
B=129-212 P positive regulation of translational initiation by iron
B=129-212 P regulation of branching involved in prostate gland morphogenesis
B=129-212 P regulation of lipid metabolic process
B=129-212 P regulation of transcription by RNA polymerase II
B=129-212 P response to retinoic acid
B=129-212 P retinoic acid receptor signaling pathway
B=129-212 P secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
B=129-212 P transcription initiation from RNA polymerase II promoter
B=129-212 P ventricular cardiac muscle cell differentiation
B=129-212 P ventricular cardiac muscle tissue morphogenesis
Sequences
Download file with secondary structure created by Stride  
1dsz.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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A (protein): 
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B (protein): 
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