General information
PDB ID 1GT0
Title CRYSTAL STRUCTURE OF A POU/HMG/DNA TERNARY COMPLEX
PDB header TRANSCRIPTION
Date 2002-01-09
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.6
Kind dna
Organism MUS MUSCULUS, HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1gt0.pdb CD AB 0
Biounits:
1gt0.pdb1.pdb CD AB 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Pou Domain P14859_283-354 2.2e-36 1 CL0123 C 4 75 AB  H-Bb H-Mj L-Bb 
Homeodomain Domain P14859_380-436 9.1e-18 1 CL0123 C 102 158 AB  H-Bb H-Mj L-Bb L-Mn 
HMG_box Domain P48432_43-111 6.2e-29 1 CL0114 D 3 71 AB  H-Bb H-Mj H-Mn L-Bb L-Mn 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: HMG-box
    Superfamily: HMG-box
      Family: HMG-box
Sox-2 D N/A N/A AB  H-Bb H-Mn L-Bb L-Mn 
Class: All alpha proteins
  Fold: lambda repressor-like DNA-binding domains
    Superfamily: lambda repressor-like DNA-binding domains
      Family: POU-specific domain
Oct-1 C 3 77 AB  H-Bb H-Mj L-Bb 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: Homeodomain-like
      Family: Homeodomain
Oct-1 POU Homeodomain C 97 159 AB  H-Bb H-Mj L-Bb L-Mn 
GO terms
Protein chains: GO type: GO description:
C=280-438 C endoplasmic reticulum
C=280-438 C intracellular membrane-bounded organelle
C=280-438 C nuclear chromatin
C=280-438 C nucleoplasm
C=280-438 C nucleus
C=280-438 C RNA polymerase II transcription regulator complex
C=280-438 F DNA binding
C=280-438 F DNA-binding transcription activator activity, RNA polymerase II-specific
C=280-438 F DNA-binding transcription factor activity, RNA polymerase II-specific
C=280-438 F identical protein binding
C=280-438 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
C=280-438 F RNA polymerase II core promoter sequence-specific DNA binding
C=280-438 F sequence-specific DNA binding
C=280-438 P cell differentiation
C=280-438 P cytokine-mediated signaling pathway
C=280-438 P negative regulation of transcription, DNA-templated
C=280-438 P positive regulation of transcription by RNA polymerase II
C=280-438 P snRNA transcription by RNA polymerase II
D=41-120 C cytoplasm
D=41-120 C cytosol
D=41-120 C nucleoplasm
D=41-120 C nucleus
D=41-120 C transcription regulator complex
D=41-120 F chromatin binding
D=41-120 F chromatin DNA binding
D=41-120 F DNA binding
D=41-120 F DNA-binding transcription factor activity
D=41-120 F DNA-binding transcription factor activity, RNA polymerase II-specific
D=41-120 F miRNA binding
D=41-120 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
D=41-120 F sequence-specific DNA binding
D=41-120 F transcription factor binding
D=41-120 F transcription regulatory region sequence-specific DNA binding
D=41-120 P adenohypophysis development
D=41-120 P anatomical structure formation involved in morphogenesis
D=41-120 P anatomical structure morphogenesis
D=41-120 P cell cycle arrest
D=41-120 P cell differentiation
D=41-120 P cell fate commitment
D=41-120 P cell fate specification
D=41-120 P cerebral cortex development
D=41-120 P detection of mechanical stimulus involved in equilibrioception
D=41-120 P detection of mechanical stimulus involved in sensory perception of sound
D=41-120 P diencephalon morphogenesis
D=41-120 P embryonic organ development
D=41-120 P endodermal cell fate specification
D=41-120 P epithelial tube branching involved in lung morphogenesis
D=41-120 P forebrain development
D=41-120 P forebrain neuron differentiation
D=41-120 P inner ear development
D=41-120 P inner ear morphogenesis
D=41-120 P lens induction in camera-type eye
D=41-120 P lung alveolus development
D=41-120 P male genitalia development
D=41-120 P negative regulation of canonical Wnt signaling pathway
D=41-120 P negative regulation of cell differentiation
D=41-120 P negative regulation of epithelial cell proliferation
D=41-120 P negative regulation of neuron differentiation
D=41-120 P negative regulation of osteoblast differentiation
D=41-120 P negative regulation of transcription by RNA polymerase II
D=41-120 P negative regulation of Wnt signaling pathway
D=41-120 P neuron fate commitment
D=41-120 P neuronal stem cell population maintenance
D=41-120 P olfactory placode formation
D=41-120 P osteoblast differentiation
D=41-120 P pigment biosynthetic process
D=41-120 P positive regulation of cell differentiation
D=41-120 P positive regulation of cell-cell adhesion
D=41-120 P positive regulation of epithelial cell differentiation
D=41-120 P positive regulation of MAPK cascade
D=41-120 P positive regulation of neuroblast proliferation
D=41-120 P positive regulation of neuron differentiation
D=41-120 P positive regulation of Notch signaling pathway
D=41-120 P positive regulation of transcription by RNA polymerase II
D=41-120 P positive regulation of transcription, DNA-templated
D=41-120 P regulation of cysteine-type endopeptidase activity involved in apoptotic process
D=41-120 P regulation of gene expression
D=41-120 P regulation of neurogenesis
D=41-120 P regulation of transcription by RNA polymerase II
D=41-120 P regulation of transcription, DNA-templated
D=41-120 P response to growth factor
D=41-120 P response to organic substance
D=41-120 P response to retinoic acid
D=41-120 P retina morphogenesis in camera-type eye
D=41-120 P sensory perception of sound
D=41-120 P somatic stem cell population maintenance
D=41-120 P stem cell differentiation
D=41-120 P stem cell population maintenance
D=41-120 P tongue development
Sequences
Download file with secondary structure created by Stride  
1gt0.pdb1.pdb:   [ download sequences in FASTA format ]
A (dna): 
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B (dna): 
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C (protein): 
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D (protein): 
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