General information
PDB ID 1HCQ
Title THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORS DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS
PDB header TRANSCRIPTION/DNA
Date 1995-01-04
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.4
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1hcq.pdb ABEF CDGH 0
Biounits:
1hcq.pdb1.pdb AB CD 1
1hcq.pdb2.pdb EF GH 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
zf-C4 Domain P03372_183-252 2.7e-33 1 CL0167 A 5 74 CD  H-Bb H-Mj S-Bb L-Bb 
zf-C4 Domain P03372_183-252 2.3e-33 1 CL0167 B 5 74 CD  H-Bb H-Mj S-Bb L-Bb 
zf-C4 Domain P03372_183-252 2.7e-33 1 CL0167 E 5 74 GH  H-Bb H-Mj S-Bb L-Bb 
zf-C4 Domain P03372_183-252 6.2e-31 1 CL0167 F 5 74 GH  H-Bb H-Mj S-Bb L-Bb 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: Small proteins
  Fold: Glucocorticoid receptor-like (DNA-binding domain)
    Superfamily: Glucocorticoid receptor-like (DNA-binding domain)
      Family: Nuclear receptor
Estrogen receptor DNA-binding domain A N/A N/A CD  H-Bb H-Mj S-Bb L-Bb 
Class: Small proteins
  Fold: Glucocorticoid receptor-like (DNA-binding domain)
    Superfamily: Glucocorticoid receptor-like (DNA-binding domain)
      Family: Nuclear receptor
Estrogen receptor DNA-binding domain B N/A N/A CD  H-Bb H-Mj S-Bb L-Bb 
Class: Small proteins
  Fold: Glucocorticoid receptor-like (DNA-binding domain)
    Superfamily: Glucocorticoid receptor-like (DNA-binding domain)
      Family: Nuclear receptor
Estrogen receptor DNA-binding domain E N/A N/A GH  H-Bb H-Mj S-Bb L-Bb 
Class: Small proteins
  Fold: Glucocorticoid receptor-like (DNA-binding domain)
    Superfamily: Glucocorticoid receptor-like (DNA-binding domain)
      Family: Nuclear receptor
Estrogen receptor DNA-binding domain F N/A N/A GH  H-Bb H-Mj S-Bb L-Bb 
GO terms
Protein chains: GO type: GO description:
A/B/E/F=180-262 C cytoplasm
A/B/E/F=180-262 C cytosol
A/B/E/F=180-262 C Golgi apparatus
A/B/E/F=180-262 C integral component of membrane
A/B/E/F=180-262 C membrane
A/B/E/F=180-262 C nuclear chromatin
A/B/E/F=180-262 C nucleoplasm
A/B/E/F=180-262 C nucleus
A/B/E/F=180-262 C plasma membrane
A/B/E/F=180-262 C protein-containing complex
A/B/E/F=180-262 C transcription preinitiation complex
A/B/E/F=180-262 C transcriptionally active chromatin
A/B/E/F=180-262 F ATPase binding
A/B/E/F=180-262 F beta-catenin binding
A/B/E/F=180-262 F chromatin binding
A/B/E/F=180-262 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/B/E/F=180-262 F DNA-binding transcription factor activity
A/B/E/F=180-262 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/B/E/F=180-262 F enzyme binding
A/B/E/F=180-262 F estrogen receptor activity
A/B/E/F=180-262 F estrogen receptor binding
A/B/E/F=180-262 F estrogen response element binding
A/B/E/F=180-262 F identical protein binding
A/B/E/F=180-262 F nitric-oxide synthase regulator activity
A/B/E/F=180-262 F nuclear receptor activity
A/B/E/F=180-262 F protein kinase binding
A/B/E/F=180-262 F repressing transcription factor binding
A/B/E/F=180-262 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/B/E/F=180-262 F RNA polymerase II transcription corepressor binding
A/B/E/F=180-262 F sequence-specific double-stranded DNA binding
A/B/E/F=180-262 F steroid binding
A/B/E/F=180-262 F TBP-class protein binding
A/B/E/F=180-262 F TFIIB-class transcription factor binding
A/B/E/F=180-262 F transcription coactivator binding
A/B/E/F=180-262 F transcription factor binding
A/B/E/F=180-262 F zinc ion binding
A/B/E/F=180-262 P androgen metabolic process
A/B/E/F=180-262 P antral ovarian follicle growth
A/B/E/F=180-262 P cellular response to estradiol stimulus
A/B/E/F=180-262 P cellular response to estrogen stimulus
A/B/E/F=180-262 P chromatin remodeling
A/B/E/F=180-262 P epithelial cell development
A/B/E/F=180-262 P epithelial cell proliferation involved in mammary gland duct elongation
A/B/E/F=180-262 P intracellular estrogen receptor signaling pathway
A/B/E/F=180-262 P intracellular steroid hormone receptor signaling pathway
A/B/E/F=180-262 P male gonad development
A/B/E/F=180-262 P mammary gland alveolus development
A/B/E/F=180-262 P mammary gland branching involved in pregnancy
A/B/E/F=180-262 P negative regulation of DNA-binding transcription factor activity
A/B/E/F=180-262 P negative regulation of gene expression
A/B/E/F=180-262 P negative regulation of I-kappaB kinase/NF-kappaB signaling
A/B/E/F=180-262 P negative regulation of production of miRNAs involved in gene silencing by miRNA
A/B/E/F=180-262 P negative regulation of transcription by RNA polymerase II
A/B/E/F=180-262 P phospholipase C-activating G protein-coupled receptor signaling pathway
A/B/E/F=180-262 P positive regulation of cytosolic calcium ion concentration
A/B/E/F=180-262 P positive regulation of DNA-binding transcription factor activity
A/B/E/F=180-262 P positive regulation of fibroblast proliferation
A/B/E/F=180-262 P positive regulation of nitric oxide biosynthetic process
A/B/E/F=180-262 P positive regulation of nitric-oxide synthase activity
A/B/E/F=180-262 P positive regulation of phospholipase C activity
A/B/E/F=180-262 P positive regulation of protein kinase B signaling
A/B/E/F=180-262 P positive regulation of RNA polymerase II transcription preinitiation complex assembly
A/B/E/F=180-262 P positive regulation of transcription by RNA polymerase II
A/B/E/F=180-262 P positive regulation of transcription, DNA-templated
A/B/E/F=180-262 P prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
A/B/E/F=180-262 P prostate epithelial cord elongation
A/B/E/F=180-262 P protein deubiquitination
A/B/E/F=180-262 P protein localization to chromatin
A/B/E/F=180-262 P regulation of apoptotic process
A/B/E/F=180-262 P regulation of branching involved in prostate gland morphogenesis
A/B/E/F=180-262 P regulation of inflammatory response
A/B/E/F=180-262 P regulation of intracellular estrogen receptor signaling pathway
A/B/E/F=180-262 P regulation of toll-like receptor signaling pathway
A/B/E/F=180-262 P regulation of transcription by RNA polymerase II
A/B/E/F=180-262 P regulation of transcription, DNA-templated
A/B/E/F=180-262 P regulation of Wnt signaling pathway
A/B/E/F=180-262 P response to estradiol
A/B/E/F=180-262 P response to estrogen
A/B/E/F=180-262 P signal transduction
A/B/E/F=180-262 P stem cell differentiation
A/B/E/F=180-262 P transcription initiation from RNA polymerase II promoter
A/B/E/F=180-262 P uterus development
A/B/E/F=180-262 P vagina development
Sequences
Download file with secondary structure created by Stride  
1hcq.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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A (protein): 
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B (protein): 
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1hcq.pdb2.pdb:   [ download sequences in FASTA format ]
G (dna): 
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H (dna): 
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E (protein): 
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F (protein): 
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