General information
PDB ID 1HJB
Title CRYSTAL STRUCTURE OF RUNX-1/AML1/CBFALPHA RUNT DOMAIN AND C/EBPBETA BZIP HOMODIMER BOUND TO A DNA FRAGMENT FROM THE CSF-1R PROMOTER
PDB header TRANSCRIPTION/DNA
Date 2001-01-11
Experimental method X-RAY DIFFRACTION
Resolution (A) 3
Kind dna
Organism HOMO SAPIENS, MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1hjb.pdb ABCDEF GHIJ 0
Biounits:
1hjb.pdb1.pdb ABC GH 1
1hjb.pdb2.pdb DEF IJ 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
bZIP_2 Coiled-coil P17676_270-323 2.6e-19 1 CL0018 A 270 323 GH  H-Bb H-Mj 
bZIP_2 Coiled-coil P17676_270-323 2.7e-19 1 CL0018 B 270 323 GH  H-Bb H-Mj 
Taxilin Coiled-coil P17676_275-326 0.00052 0 No_clan B 277 334 GH  H-Bb H-Mj 
bZIP_2 Coiled-coil P17676_270-323 2.8e-19 1 CL0018 D 270 323 IJ  H-Bb H-Mj 
Taxilin Coiled-coil P17676_275-326 0.00016 0 No_clan D 277 335 IJ  H-Bb H-Mj 
bZIP_2 Coiled-coil P17676_270-323 2.8e-19 1 CL0018 E 270 323 IJ  H-Bb H-Mj 
Taxilin Coiled-coil P17676_275-326 0.00016 0 No_clan E 277 335 IJ  H-Bb H-Mj 
Runt Domain Q03347_60-179 6.8e-73 1 CL0073 C 60 179 GH  S-Bb S-Mj L-Bb L-Mj L-Mn 
Runt Domain Q03347_60-179 6.8e-73 1 CL0073 F 60 179 IJ  S-Bb S-Mj L-Bb L-Mj L-Mn 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: RUNT domain
Acute myeloid leukemia 1 protein (AML1), RUNT domain C N/A N/A GH  S-Bb S-Mj L-Bb L-Mj L-Mn 
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: RUNT domain
Acute myeloid leukemia 1 protein (AML1), RUNT domain F N/A N/A IJ  S-Bb S-Mj L-Bb L-Mj L-Mn 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C/ebp beta A N/A N/A GH  H-Bb H-Mj 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C/ebp beta B N/A N/A GH  H-Bb H-Mj 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C/ebp beta D N/A N/A IJ  H-Bb H-Mj L-Bb 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C/ebp beta E N/A N/A IJ  H-Bb H-Mj 
GO terms
Protein chains: GO type: GO description:
A/B/D/E=259-345 C CHOP-C/EBP complex
A/B/D/E=259-345 C condensed chromosome, centromeric region
A/B/D/E=259-345 C cytoplasm
A/B/D/E=259-345 C nuclear chromatin
A/B/D/E=259-345 C nuclear matrix
A/B/D/E=259-345 C nucleoplasm
A/B/D/E=259-345 C nucleus
A/B/D/E=259-345 F chromatin binding
A/B/D/E=259-345 F DNA binding
A/B/D/E=259-345 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/B/D/E=259-345 F DNA-binding transcription factor activity
A/B/D/E=259-345 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/B/D/E=259-345 F DNA-binding transcription repressor activity, RNA polymerase II-specific
A/B/D/E=259-345 F glucocorticoid receptor binding
A/B/D/E=259-345 F histone acetyltransferase binding
A/B/D/E=259-345 F histone deacetylase binding
A/B/D/E=259-345 F kinase binding
A/B/D/E=259-345 F protein heterodimerization activity
A/B/D/E=259-345 F protein homodimerization activity
A/B/D/E=259-345 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/B/D/E=259-345 F RNA polymerase II core promoter sequence-specific DNA binding
A/B/D/E=259-345 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
A/B/D/E=259-345 F sequence-specific double-stranded DNA binding
A/B/D/E=259-345 F ubiquitin-like protein ligase binding
A/B/D/E=259-345 P acute-phase response
A/B/D/E=259-345 P brown fat cell differentiation
A/B/D/E=259-345 P cellular response to amino acid stimulus
A/B/D/E=259-345 P cellular response to interleukin-1
A/B/D/E=259-345 P cellular response to lipopolysaccharide
A/B/D/E=259-345 P cellular response to organic cyclic compound
A/B/D/E=259-345 P defense response to bacterium
A/B/D/E=259-345 P embryonic placenta development
A/B/D/E=259-345 P granuloma formation
A/B/D/E=259-345 P hepatocyte proliferation
A/B/D/E=259-345 P immune response
A/B/D/E=259-345 P inflammatory response
A/B/D/E=259-345 P intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
A/B/D/E=259-345 P liver regeneration
A/B/D/E=259-345 P mammary gland epithelial cell differentiation
A/B/D/E=259-345 P mammary gland epithelial cell proliferation
A/B/D/E=259-345 P memory
A/B/D/E=259-345 P negative regulation of neuron apoptotic process
A/B/D/E=259-345 P negative regulation of T cell proliferation
A/B/D/E=259-345 P negative regulation of transcription by RNA polymerase II
A/B/D/E=259-345 P neuron differentiation
A/B/D/E=259-345 P ovarian follicle development
A/B/D/E=259-345 P positive regulation of biomineral tissue development
A/B/D/E=259-345 P positive regulation of cold-induced thermogenesis
A/B/D/E=259-345 P positive regulation of fat cell differentiation
A/B/D/E=259-345 P positive regulation of inflammatory response
A/B/D/E=259-345 P positive regulation of interleukin-4 production
A/B/D/E=259-345 P positive regulation of osteoblast differentiation
A/B/D/E=259-345 P positive regulation of sodium-dependent phosphate transport
A/B/D/E=259-345 P positive regulation of transcription by RNA polymerase II
A/B/D/E=259-345 P positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
A/B/D/E=259-345 P positive regulation of transcription, DNA-templated
A/B/D/E=259-345 P regulation of dendritic cell differentiation
A/B/D/E=259-345 P regulation of interleukin-6 production
A/B/D/E=259-345 P regulation of odontoblast differentiation
A/B/D/E=259-345 P regulation of osteoclast differentiation
A/B/D/E=259-345 P regulation of transcription involved in cell fate commitment
A/B/D/E=259-345 P regulation of transcription, DNA-templated
A/B/D/E=259-345 P response to endoplasmic reticulum stress
A/B/D/E=259-345 P T-helper 1 cell activation
C/F=60-182 C basement membrane
C/F=60-182 C core-binding factor complex
C/F=60-182 C intracellular membrane-bounded organelle
C/F=60-182 C nucleoplasm
C/F=60-182 C nucleus
C/F=60-182 C protein-containing complex
C/F=60-182 F ATP binding
C/F=60-182 F calcium ion binding
C/F=60-182 F DNA binding
C/F=60-182 F DNA-binding transcription activator activity, RNA polymerase II-specific
C/F=60-182 F DNA-binding transcription factor activity
C/F=60-182 F DNA-binding transcription factor activity, RNA polymerase II-specific
C/F=60-182 F promoter-specific chromatin binding
C/F=60-182 F protein heterodimerization activity
C/F=60-182 F protein homodimerization activity
C/F=60-182 F repressing transcription factor binding
C/F=60-182 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
C/F=60-182 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
C/F=60-182 F sequence-specific double-stranded DNA binding
C/F=60-182 F transcription factor binding
C/F=60-182 F transcription regulatory region sequence-specific DNA binding
C/F=60-182 P behavioral response to pain
C/F=60-182 P cellular response to transforming growth factor beta stimulus
C/F=60-182 P central nervous system development
C/F=60-182 P chondrocyte differentiation
C/F=60-182 P definitive hemopoiesis
C/F=60-182 P embryonic hemopoiesis
C/F=60-182 P hair follicle morphogenesis
C/F=60-182 P hemopoiesis
C/F=60-182 P in utero embryonic development
C/F=60-182 P liver development
C/F=60-182 P myeloid cell differentiation
C/F=60-182 P myeloid progenitor cell differentiation
C/F=60-182 P negative regulation of CD4-positive, alpha-beta T cell differentiation
C/F=60-182 P negative regulation of cell population proliferation
C/F=60-182 P negative regulation of granulocyte differentiation
C/F=60-182 P negative regulation of transcription by RNA polymerase II
C/F=60-182 P negative regulation of transcription, DNA-templated
C/F=60-182 P neuron development
C/F=60-182 P neuron differentiation
C/F=60-182 P neuron fate commitment
C/F=60-182 P ossification
C/F=60-182 P positive regulation of angiogenesis
C/F=60-182 P positive regulation of CD8-positive, alpha-beta T cell differentiation
C/F=60-182 P positive regulation of cell maturation
C/F=60-182 P positive regulation of granulocyte differentiation
C/F=60-182 P positive regulation of interferon-gamma production
C/F=60-182 P positive regulation of interleukin-2 production
C/F=60-182 P positive regulation of progesterone secretion
C/F=60-182 P positive regulation of transcription by RNA polymerase II
C/F=60-182 P positive regulation of transcription, DNA-templated
C/F=60-182 P regulation of cell differentiation
C/F=60-182 P regulation of hair follicle cell proliferation
C/F=60-182 P regulation of signal transduction
C/F=60-182 P regulation of T cell anergy
C/F=60-182 P regulation of transcription by RNA polymerase II
C/F=60-182 P regulation of transcription, DNA-templated
C/F=60-182 P response to retinoic acid
C/F=60-182 P skeletal system development
Sequences
Download file with secondary structure created by Stride  
1hjb.pdb1.pdb:   [ download sequences in FASTA format ]
G (dna): 
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H (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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1hjb.pdb2.pdb:   [ download sequences in FASTA format ]
I (dna): 
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J (dna): 
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D (protein): 
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E (protein): 
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F (protein): 
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