General information
PDB ID 1IC8
Title HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT
PDB header TRANSCRIPTION/DNA
Date 2001-03-30
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.6
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1ic8.pdb AB EF 0
Biounits:
1ic8.pdb1.pdb AB EF 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Homeodomain Domain P20823_183-252 0.00067 0 CL0123 A 180 275 EF  H-Bb H-Mj L-Bb 
Homeodomain Domain P20823_183-252 0.00077 0 CL0123 B 179 275 EF  H-Bb H-Mj L-Bb L-Mn 
HNF-1_N Family P20823_87-168 1.1e-45 1 CL0123 A 87 168 EF  H-Bb H-Mj L-Bb L-Mj 
HNF-1_N Family P20823_87-168 6.5e-46 1 CL0123 B 85 168 EF  H-Bb H-Mj L-Bb L-Mj 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: lambda repressor-like DNA-binding domains
    Superfamily: lambda repressor-like DNA-binding domains
      Family: POU-specific domain
Hepatocyte nuclear factor 1a (LFB1/HNF1) A 87 180 EF  H-Bb H-Mj L-Bb L-Mj 
Class: All alpha proteins
  Fold: lambda repressor-like DNA-binding domains
    Superfamily: lambda repressor-like DNA-binding domains
      Family: POU-specific domain
Hepatocyte nuclear factor 1a (LFB1/HNF1) B 85 179 EF  H-Bb H-Mj L-Bb L-Mj 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: Homeodomain-like
      Family: Homeodomain
Hepatocyte nuclear factor 1a (LFB1/HNF1) A 201 276 EF  H-Bb H-Mj L-Bb 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: Homeodomain-like
      Family: Homeodomain
Hepatocyte nuclear factor 1a (LFB1/HNF1) B 201 278 EF  H-Bb H-Mj L-Bb L-Mn 
GO terms
Protein chains: GO type: GO description:
A/B=85-278 C cytoplasm
A/B=85-278 C nuclear chromatin
A/B=85-278 C nucleus
A/B=85-278 C protein-containing complex
A/B=85-278 F DNA binding
A/B=85-278 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/B=85-278 F DNA-binding transcription factor activity
A/B=85-278 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/B=85-278 F protein dimerization activity
A/B=85-278 F protein heterodimerization activity
A/B=85-278 F protein homodimerization activity
A/B=85-278 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
A/B=85-278 F transcription regulatory region sequence-specific DNA binding
A/B=85-278 P glucose homeostasis
A/B=85-278 P glucose import
A/B=85-278 P insulin secretion
A/B=85-278 P liver development
A/B=85-278 P pancreas development
A/B=85-278 P positive regulation of transcription by RNA polymerase II
A/B=85-278 P positive regulation of transcription initiation from RNA polymerase II promoter
A/B=85-278 P positive regulation of transcription, DNA-templated
A/B=85-278 P regulation of transcription by RNA polymerase II
A/B=85-278 P renal glucose absorption
Sequences
Download file with secondary structure created by Stride  
1ic8.pdb1.pdb:   [ download sequences in FASTA format ]
E (dna): 
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F (dna): 
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A (protein): 
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B (protein): 
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