General information
PDB ID 1K6O
Title CRYSTAL STRUCTURE OF A TERNARY SAP-1/SRF/C-FOS SRE DNA COMPLEX
PDB header TRANSCRIPTION/DNA
Date 2001-10-16
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.19
Kind dna
Organism HOMO SAPIENS
Download
complex
View in
Jmol
Quick Links
PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1k6o.pdb ABC DE 0
Biounits:
1k6o.pdb1.pdb ABC DE 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Ets Domain P28324_6-85 4.4e-36 1 CL0123 A 306 385 DE  H-Bb H-Mj L-Bb 
SRF-TF Domain P11831_150-197 9.1e-21 1 No_clan B 150 197 DE  H-Bb H-Mj 
SRF-TF Domain P11831_150-197 8.8e-21 1 No_clan C 150 197 DE  H-Bb H-Mj 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: ets domain
Serum response factor accessory protein 1a, SAP-1 A N/A N/A DE  H-Bb H-Mj L-Bb 
Class: Alpha and beta proteins (a+b)
  Fold: SRF-like
    Superfamily: SRF-like
      Family: SRF-like
Serum response factor (SRF) core B N/A N/A DE  H-Bb H-Mj L-Bb L-Mn 
Class: Alpha and beta proteins (a+b)
  Fold: SRF-like
    Superfamily: SRF-like
      Family: SRF-like
Serum response factor (SRF) core C N/A N/A DE  H-Bb H-Mj L-Mn 
GO terms
Protein chains: GO type: GO description:
A=1-93 C cytosol
A=1-93 C nuclear chromatin
A=1-93 C nucleoplasm
A=1-93 C nucleus
A=1-93 F chromatin binding
A=1-93 F DNA binding
A=1-93 F DNA-binding transcription activator activity, RNA polymerase II-specific
A=1-93 F DNA-binding transcription factor activity
A=1-93 F DNA-binding transcription factor activity, RNA polymerase II-specific
A=1-93 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A=1-93 F sequence-specific double-stranded DNA binding
A=1-93 P cell differentiation
A=1-93 P histone H3 deacetylation
A=1-93 P negative regulation of transcription by RNA polymerase II
A=1-93 P positive regulation of transcription by RNA polymerase II
A=1-93 P regulation of transcription by RNA polymerase II
B/C=133-235 C cytoplasm
B/C=133-235 C nuclear chromatin
B/C=133-235 C nucleoplasm
B/C=133-235 C nucleus
B/C=133-235 F chromatin DNA binding
B/C=133-235 F DNA-binding transcription activator activity, RNA polymerase II-specific
B/C=133-235 F DNA-binding transcription factor activity
B/C=133-235 F DNA-binding transcription factor activity, RNA polymerase II-specific
B/C=133-235 F histone deacetylase binding
B/C=133-235 F primary miRNA binding
B/C=133-235 F protein homodimerization activity
B/C=133-235 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
B/C=133-235 F RNA polymerase II-specific DNA-binding transcription factor binding
B/C=133-235 F sequence-specific double-stranded DNA binding
B/C=133-235 F serum response element binding
B/C=133-235 F transcription factor binding
B/C=133-235 P actin cytoskeleton organization
B/C=133-235 P angiogenesis involved in wound healing
B/C=133-235 P associative learning
B/C=133-235 P bicellular tight junction assembly
B/C=133-235 P branching involved in blood vessel morphogenesis
B/C=133-235 P bronchus cartilage development
B/C=133-235 P cardiac myofibril assembly
B/C=133-235 P cardiac vascular smooth muscle cell differentiation
B/C=133-235 P cell migration involved in sprouting angiogenesis
B/C=133-235 P cell-matrix adhesion
B/C=133-235 P cellular response to glucose stimulus
B/C=133-235 P cellular senescence
B/C=133-235 P developmental growth
B/C=133-235 P dorsal aorta morphogenesis
B/C=133-235 P epithelial cell-cell adhesion
B/C=133-235 P epithelial structure maintenance
B/C=133-235 P erythrocyte development
B/C=133-235 P eyelid development in camera-type eye
B/C=133-235 P face development
B/C=133-235 P heart development
B/C=133-235 P heart looping
B/C=133-235 P heart trabecula formation
B/C=133-235 P hematopoietic stem cell differentiation
B/C=133-235 P hippocampus development
B/C=133-235 P long-term memory
B/C=133-235 P long-term synaptic depression
B/C=133-235 P lung morphogenesis
B/C=133-235 P lung smooth muscle development
B/C=133-235 P megakaryocyte development
B/C=133-235 P mesoderm formation
B/C=133-235 P morphogenesis of an epithelial sheet
B/C=133-235 P muscle cell cellular homeostasis
B/C=133-235 P negative regulation of amyloid-beta clearance
B/C=133-235 P negative regulation of cell migration
B/C=133-235 P negative regulation of cell population proliferation
B/C=133-235 P negative regulation of pri-miRNA transcription by RNA polymerase II
B/C=133-235 P neuron development
B/C=133-235 P neuron migration
B/C=133-235 P neuron projection development
B/C=133-235 P platelet activation
B/C=133-235 P platelet formation
B/C=133-235 P positive regulation of axon extension
B/C=133-235 P positive regulation of cell differentiation
B/C=133-235 P positive regulation of DNA-binding transcription factor activity
B/C=133-235 P positive regulation of filopodium assembly
B/C=133-235 P positive regulation of pri-miRNA transcription by RNA polymerase II
B/C=133-235 P positive regulation of smooth muscle contraction
B/C=133-235 P positive regulation of transcription by glucose
B/C=133-235 P positive regulation of transcription by RNA polymerase II
B/C=133-235 P positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
B/C=133-235 P positive regulation of transcription initiation from RNA polymerase II promoter
B/C=133-235 P positive regulation of transcription via serum response element binding
B/C=133-235 P positive thymic T cell selection
B/C=133-235 P primitive streak formation
B/C=133-235 P regulation of cell adhesion
B/C=133-235 P regulation of smooth muscle cell differentiation
B/C=133-235 P regulation of water loss via skin
B/C=133-235 P response to cytokine
B/C=133-235 P response to hormone
B/C=133-235 P response to hypoxia
B/C=133-235 P response to toxic substance
B/C=133-235 P sarcomere organization
B/C=133-235 P skin morphogenesis
B/C=133-235 P stress fiber assembly
B/C=133-235 P tangential migration from the subventricular zone to the olfactory bulb
B/C=133-235 P thymus development
B/C=133-235 P thyroid gland development
B/C=133-235 P trachea cartilage development
B/C=133-235 P trophectodermal cell differentiation
Sequences
Download file with secondary structure created by Stride  
1k6o.pdb1.pdb:   [ download sequences in FASTA format ]
D (dna): 
Click "SHOW" for view sequence
E (dna): 
Click "SHOW" for view sequence
A (protein): 
Click "SHOW" for view sequence
B (protein): 
Click "SHOW" for view sequence
C (protein): 
Click "SHOW" for view sequence
© NPIDB team 2003 - 2021

text