General information
PDB ID 1MDM
Title INHIBITED FRAGMENT OF ETS-1 AND PAIRED DOMAIN OF PAX5 BOUND TO DNA
PDB header TRANSCRIPTION/DNA
Date 2002-08-07
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.8
Kind dna
Organism HOMO SAPIENS, MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1mdm.pdb AB CD 0
Biounits:
1mdm.pdb1.pdb AB CD 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
PAX Domain Q02548_19-140 7.3e-75 1 CL0123 A 19 140 CD  H-Bb H-Mj L-Bb L-Mj L-Mn 
Ets Domain P27577_336-415 1.7e-35 1 CL0123 B 336 415 CD  H-Bb H-Mj S-Bb L-Bb 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: Homeodomain-like
      Family: Paired domain
Pax-5 A 19 81 CD  H-Bb H-Mj L-Bb L-Mj L-Mn 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: Homeodomain-like
      Family: Paired domain
Pax-5 A 82 142 CD  H-Bb H-Mj L-Bb L-Mn 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: ets domain
ETS-1 transcription factor, residues 331-440 B N/A N/A CD  H-Bb H-Mj S-Bb L-Bb 
GO terms
Protein chains: GO type: GO description:
A=1-149 C cytosol
A=1-149 C fibrillar center
A=1-149 C intracellular membrane-bounded organelle
A=1-149 C nuclear chromatin
A=1-149 C nucleoplasm
A=1-149 F DNA-binding transcription activator activity, RNA polymerase II-specific
A=1-149 F DNA-binding transcription factor activity, RNA polymerase II-specific
A=1-149 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A=1-149 P adult behavior
A=1-149 P aging
A=1-149 P animal organ morphogenesis
A=1-149 P cerebral cortex development
A=1-149 P embryonic cranial skeleton morphogenesis
A=1-149 P humoral immune response
A=1-149 P lateral ventricle development
A=1-149 P multicellular organism development
A=1-149 P negative regulation of histone H3-K9 methylation
A=1-149 P negative regulation of transcription by RNA polymerase II
A=1-149 P regulation of B cell receptor signaling pathway
A=1-149 P skeletal muscle cell differentiation
A=1-149 P spermatogenesis
A=1-149 P transcription by RNA polymerase II
B=280-440 C cytoplasm
B=280-440 C host cell nucleus
B=280-440 C nucleoplasm
B=280-440 C nucleus
B=280-440 C transcription regulator complex
B=280-440 F DNA binding
B=280-440 F DNA-binding transcription activator activity, RNA polymerase II-specific
B=280-440 F DNA-binding transcription factor activity
B=280-440 F DNA-binding transcription factor activity, RNA polymerase II-specific
B=280-440 F histone acetyltransferase binding
B=280-440 F identical protein binding
B=280-440 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
B=280-440 F sequence-specific DNA binding
B=280-440 F sequence-specific double-stranded DNA binding
B=280-440 P angiogenesis involved in wound healing
B=280-440 P cell differentiation
B=280-440 P cell motility
B=280-440 P cellular response to hydrogen peroxide
B=280-440 P estrous cycle
B=280-440 P female pregnancy
B=280-440 P hypothalamus development
B=280-440 P immune system process
B=280-440 P negative regulation of cell cycle
B=280-440 P negative regulation of inflammatory response
B=280-440 P pituitary gland development
B=280-440 P PML body organization
B=280-440 P positive regulation of angiogenesis
B=280-440 P positive regulation of blood vessel endothelial cell migration
B=280-440 P positive regulation of cell migration
B=280-440 P positive regulation of cell population proliferation
B=280-440 P positive regulation of cellular component movement
B=280-440 P positive regulation of endothelial cell migration
B=280-440 P positive regulation of erythrocyte differentiation
B=280-440 P positive regulation of gene expression
B=280-440 P positive regulation of inflammatory response
B=280-440 P positive regulation of leukocyte adhesion to vascular endothelial cell
B=280-440 P positive regulation of pri-miRNA transcription by RNA polymerase II
B=280-440 P positive regulation of transcription by RNA polymerase II
B=280-440 P positive regulation of transcription, DNA-templated
B=280-440 P regulation of angiogenesis
B=280-440 P regulation of apoptotic process
B=280-440 P regulation of extracellular matrix disassembly
B=280-440 P regulation of transcription by RNA polymerase II
B=280-440 P response to antibiotic
B=280-440 P response to estradiol
B=280-440 P response to hypoxia
B=280-440 P response to interleukin-1
B=280-440 P response to laminar fluid shear stress
B=280-440 P response to mechanical stimulus
B=280-440 P transcription by RNA polymerase II
Sequences
Download file with secondary structure created by Stride  
1mdm.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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A (protein): 
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B (protein): 
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