General information
PDB ID 1O4X
Title TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT
PDB header TRANSCRIPTION/DNA
Date 2003-07-17
Experimental method SOLUTION NMR
Resolution (A) N/A
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1o4x.pdb AB CD 0
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Pou Domain P14859_283-354 2.8e-36 1 CL0123 A 8 79 CD  H-Bb H-Mj L-Bb 
Homeodomain Domain P14859_385-436 1.3e-16 1 CL0123 A 79 161 CD  H-Bb H-Mj 
HMG_box Domain P48431_41-109 5.7e-29 1 CL0114 B 208 276 CD  H-Bb H-Mj H-Mn L-Bb L-Mn 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: HMG-box
    Superfamily: HMG-box
      Family: HMG-box
Sox-2 B N/A N/A CD  H-Bb H-Mn L-Bb L-Mn 
Class: All alpha proteins
  Fold: lambda repressor-like DNA-binding domains
    Superfamily: lambda repressor-like DNA-binding domains
      Family: POU-specific domain
Oct-1 A 5 79 CD  H-Bb H-Mj L-Bb 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: Homeodomain-like
      Family: Homeodomain
Oct-1 POU Homeodomain A 110 163 CD  H-Bb H-Mj 
GO terms
Protein chains: GO type: GO description:
A=280-442 C endoplasmic reticulum
A=280-442 C intracellular membrane-bounded organelle
A=280-442 C nuclear chromatin
A=280-442 C nucleoplasm
A=280-442 C nucleus
A=280-442 C RNA polymerase II transcription regulator complex
A=280-442 F DNA binding
A=280-442 F DNA-binding transcription activator activity, RNA polymerase II-specific
A=280-442 F DNA-binding transcription factor activity, RNA polymerase II-specific
A=280-442 F identical protein binding
A=280-442 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A=280-442 F RNA polymerase II core promoter sequence-specific DNA binding
A=280-442 F sequence-specific DNA binding
A=280-442 P cell differentiation
A=280-442 P cytokine-mediated signaling pathway
A=280-442 P negative regulation of transcription, DNA-templated
A=280-442 P positive regulation of transcription by RNA polymerase II
A=280-442 P snRNA transcription by RNA polymerase II
B=39-121 C cytoplasm
B=39-121 C cytosol
B=39-121 C nuclear chromatin
B=39-121 C nucleoplasm
B=39-121 C nucleus
B=39-121 C transcription regulator complex
B=39-121 F DNA binding
B=39-121 F DNA-binding transcription activator activity, RNA polymerase II-specific
B=39-121 F DNA-binding transcription factor activity
B=39-121 F DNA-binding transcription factor activity, RNA polymerase II-specific
B=39-121 F miRNA binding
B=39-121 F sequence-specific DNA binding
B=39-121 F transcription regulatory region sequence-specific DNA binding
B=39-121 P adenohypophysis development
B=39-121 P anatomical structure morphogenesis
B=39-121 P cell cycle arrest
B=39-121 P cell differentiation
B=39-121 P cell fate commitment
B=39-121 P chromatin organization
B=39-121 P cytokine-mediated signaling pathway
B=39-121 P endodermal cell fate specification
B=39-121 P eye development
B=39-121 P forebrain development
B=39-121 P glial cell fate commitment
B=39-121 P inner ear development
B=39-121 P negative regulation of canonical Wnt signaling pathway
B=39-121 P negative regulation of epithelial cell proliferation
B=39-121 P negative regulation of neuron differentiation
B=39-121 P negative regulation of transcription by RNA polymerase II
B=39-121 P neuronal stem cell population maintenance
B=39-121 P osteoblast differentiation
B=39-121 P pituitary gland development
B=39-121 P positive regulation of cell differentiation
B=39-121 P positive regulation of cell-cell adhesion
B=39-121 P positive regulation of MAPK cascade
B=39-121 P positive regulation of transcription by RNA polymerase II
B=39-121 P positive regulation of transcription, DNA-templated
B=39-121 P regulation of cysteine-type endopeptidase activity involved in apoptotic process
B=39-121 P regulation of gene expression
B=39-121 P regulation of transcription, DNA-templated
B=39-121 P response to growth factor
B=39-121 P response to wounding
B=39-121 P somatic stem cell population maintenance
B=39-121 P tissue regeneration
Sequences
Download file with secondary structure created by Stride  
pdb1o4x.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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A (protein): 
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B (protein): 
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