General information
PDB ID 1RRJ
Title STRUCTURAL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY MUTATIONS IN HUMAN TOPOISOMERASE I
PDB header ISOMERASE/DNA
Date 2003-12-08
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.3
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1rrj.pdb A BC 0
Biounits:
1rrj.pdb1.pdb A BC 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Topoisom_I Domain P11387_432-665 2.4e-101 1 CL0382 A 432 665 BC  H-Bb H-Mj H-Mn L-Bb L-Mj 
Topoisom_I_N Family P11387_215-429 1.6e-99 1 No_clan A 215 429 BC  H-Bb S-Bb S-Mj L-Bb L-Mj L-Mn 
Topo_C_assoc Family P11387_695-765 2.1e-29 1 No_clan A 695 765 BC  H-Bb 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: Long alpha-hairpin
    Superfamily: Eukaryotic DNA topoisomerase I, dispensable insert domain
      Family: Eukaryotic DNA topoisomerase I, dispensable insert domain
Eukaryotic DNA topoisomerase I, dispensable insert domain A 636 712 CB  H-Bb H-Mj 
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core A 431 635 BC  H-Bb L-Bb 
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core A 431 635 BC  H-Bb L-Bb 
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core A 713 765 BC  H-Bb 
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core A 713 765 BC  H-Bb 
Class: Multi-domain proteins (alpha and beta)
  Fold: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
    Superfamily: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
      Family: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment A 201 430 BC  H-Bb S-Bb S-Mj L-Bb L-Mj 
GO terms
Protein chains: GO type: GO description:
A=201-765 C fibrillar center
A=201-765 C nucleolus
A=201-765 C nucleoplasm
A=201-765 C nucleus
A=201-765 C P-body
A=201-765 C perikaryon
A=201-765 C protein-DNA complex
A=201-765 C replication fork protection complex
A=201-765 F ATP binding
A=201-765 F chromatin binding
A=201-765 F DNA binding
A=201-765 F DNA topoisomerase type I (single strand cut, ATP-independent) activity
A=201-765 F double-stranded DNA binding
A=201-765 F protein domain specific binding
A=201-765 F protein serine/threonine kinase activity
A=201-765 F RNA binding
A=201-765 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A=201-765 F single-stranded DNA binding
A=201-765 F supercoiled DNA binding
A=201-765 P chromatin remodeling
A=201-765 P chromosome segregation
A=201-765 P circadian regulation of gene expression
A=201-765 P circadian rhythm
A=201-765 P DNA replication
A=201-765 P DNA topological change
A=201-765 P embryonic cleavage
A=201-765 P peptidyl-serine phosphorylation
A=201-765 P phosphorylation
A=201-765 P programmed cell death
A=201-765 P response to drug
A=201-765 P viral process
Sequences
Download file with secondary structure created by Stride  
1rrj.pdb1.pdb:   [ download sequences in FASTA format ]
B (dna): 
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C (dna): 
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A (protein): 
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