General information
PDB ID 1S9K
Title CRYSTAL STRUCTURE OF HUMAN NFAT1 AND FOS-JUN ON THE IL-2 ARRE1 SITE
PDB header TRANSCRIPTION/DNA
Date 2004-02-04
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.1
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1s9k.pdb CDE AB 0
Biounits:
1s9k.pdb1.pdb CDE AB 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
bZIP_1 Coiled-coil P01100_140-192 2.1e-08 1 CL0018 D 140 192 AB  H-Bb H-Mj 
bZIP_1 Coiled-coil P05412_257-308 9.4e-16 1 CL0018 E 267 318 AB  H-Bb H-Mj L-Bb 
RHD_dimer Domain Q13469_579-678 1.1e-26 1 CL0159 C 579 678   
RHD_DNA_bind Domain Q13469_410-570 5.2e-23 1 CL0073 C 410 570 AB  H-Bb S-Bb L-Bb L-Mj 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All beta proteins
  Fold: Immunoglobulin-like beta-sandwich
    Superfamily: E set domains
      Family: NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
T-cell transcription factor NFAT1 (NFATC2) C 576 678 -
Class: All beta proteins
  Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
    Superfamily: p53-like transcription factors
      Family: Rel/Dorsal transcription factors, DNA-binding domain
T-cell transcription factor NFAT1 (NFATC), DNA-binding domain C 399 575 AB  H-Bb H-Mj S-Bb L-Bb L-Mj 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C-jun E 267 318 AB  H-Bb H-Mj 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C-fos D 140 192 AB  H-Bb H-Mj 
GO terms
Protein chains: GO type: GO description:
C=399-678 C cytoplasm
C=399-678 C cytosol
C=399-678 C nuclear chromatin
C=399-678 C nucleoplasm
C=399-678 C nucleus
C=399-678 C ribonucleoprotein complex
C=399-678 C transcription regulator complex
C=399-678 F chromatin binding
C=399-678 F DNA binding
C=399-678 F DNA-binding transcription activator activity, RNA polymerase II-specific
C=399-678 F DNA-binding transcription factor activity
C=399-678 F DNA-binding transcription factor activity, RNA polymerase II-specific
C=399-678 F DNA-binding transcription repressor activity, RNA polymerase II-specific
C=399-678 F phosphatase binding
C=399-678 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
C=399-678 F sequence-specific double-stranded DNA binding
C=399-678 F transcription factor binding
C=399-678 P B cell receptor signaling pathway
C=399-678 P calcineurin-NFAT signaling cascade
C=399-678 P cell migration
C=399-678 P cellular response to DNA damage stimulus
C=399-678 P cytokine production
C=399-678 P Fc-epsilon receptor signaling pathway
C=399-678 P myotube cell development
C=399-678 P negative regulation of vascular associated smooth muscle cell differentiation
C=399-678 P positive regulation of B cell proliferation
C=399-678 P positive regulation of myoblast fusion
C=399-678 P positive regulation of transcription by RNA polymerase II
C=399-678 P positive regulation of transcription, DNA-templated
C=399-678 P regulation of regulatory T cell differentiation
C=399-678 P regulation of transcription, DNA-templated
C=399-678 P response to drug
D=140-192 C cytosol
D=140-192 C endoplasmic reticulum
D=140-192 C membrane
D=140-192 C neuron projection
D=140-192 C nuclear chromatin
D=140-192 C nucleoplasm
D=140-192 C nucleus
D=140-192 C protein-DNA complex
D=140-192 C transcription factor AP-1 complex
D=140-192 F chromatin binding
D=140-192 F DNA-binding transcription activator activity, RNA polymerase II-specific
D=140-192 F DNA-binding transcription factor activity
D=140-192 F DNA-binding transcription factor activity, RNA polymerase II-specific
D=140-192 F protein-containing complex binding
D=140-192 F R-SMAD binding
D=140-192 F RNA polymerase II activating transcription factor binding
D=140-192 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
D=140-192 F RNA polymerase II core promoter sequence-specific DNA binding
D=140-192 F sequence-specific double-stranded DNA binding
D=140-192 F transcription factor binding
D=140-192 F transcription regulatory region sequence-specific DNA binding
D=140-192 P aging
D=140-192 P cellular response to cadmium ion
D=140-192 P cellular response to calcium ion
D=140-192 P cellular response to extracellular stimulus
D=140-192 P cellular response to hormone stimulus
D=140-192 P cellular response to reactive oxygen species
D=140-192 P conditioned taste aversion
D=140-192 P cytokine-mediated signaling pathway
D=140-192 P DNA methylation
D=140-192 P Fc-epsilon receptor signaling pathway
D=140-192 P female pregnancy
D=140-192 P inflammatory response
D=140-192 P nervous system development
D=140-192 P positive regulation of neuron death
D=140-192 P positive regulation of osteoclast differentiation
D=140-192 P positive regulation of pri-miRNA transcription by RNA polymerase II
D=140-192 P positive regulation of transcription by RNA polymerase II
D=140-192 P positive regulation of transcription, DNA-templated
D=140-192 P regulation of DNA-binding transcription factor activity
D=140-192 P regulation of transcription by RNA polymerase II
D=140-192 P response to cAMP
D=140-192 P response to cold
D=140-192 P response to corticosterone
D=140-192 P response to drug
D=140-192 P response to gravity
D=140-192 P response to immobilization stress
D=140-192 P response to light stimulus
D=140-192 P response to lipopolysaccharide
D=140-192 P response to muscle stretch
D=140-192 P response to progesterone
D=140-192 P response to toxic substance
D=140-192 P skeletal muscle cell differentiation
D=140-192 P sleep
D=140-192 P SMAD protein signal transduction
D=140-192 P transcription by RNA polymerase II
D=140-192 P transforming growth factor beta receptor signaling pathway
E=257-308 C cytosol
E=257-308 C nuclear chromatin
E=257-308 C nuclear chromosome
E=257-308 C nuclear euchromatin
E=257-308 C nucleoplasm
E=257-308 C nucleus
E=257-308 C transcription factor AP-1 complex
E=257-308 C transcription regulator complex
E=257-308 C transcription repressor complex
E=257-308 F cAMP response element binding
E=257-308 F chromatin binding
E=257-308 F DNA binding
E=257-308 F DNA-binding transcription activator activity, RNA polymerase II-specific
E=257-308 F DNA-binding transcription factor activity
E=257-308 F DNA-binding transcription factor activity, RNA polymerase II-specific
E=257-308 F DNA-binding transcription repressor activity, RNA polymerase II-specific
E=257-308 F enzyme binding
E=257-308 F GTPase activator activity
E=257-308 F HMG box domain binding
E=257-308 F identical protein binding
E=257-308 F protein-containing complex binding
E=257-308 F R-SMAD binding
E=257-308 F RNA binding
E=257-308 F RNA polymerase II activating transcription factor binding
E=257-308 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
E=257-308 F sequence-specific double-stranded DNA binding
E=257-308 F transcription coactivator activity
E=257-308 F transcription factor binding
E=257-308 F transcription regulatory region sequence-specific DNA binding
E=257-308 F ubiquitin protein ligase binding
E=257-308 F ubiquitin-like protein ligase binding
E=257-308 P aging
E=257-308 P angiogenesis
E=257-308 P axon regeneration
E=257-308 P cellular response to cadmium ion
E=257-308 P cellular response to calcium ion
E=257-308 P cellular response to hormone stimulus
E=257-308 P cellular response to potassium ion starvation
E=257-308 P cellular response to reactive oxygen species
E=257-308 P circadian rhythm
E=257-308 P eyelid development in camera-type eye
E=257-308 P Fc-epsilon receptor signaling pathway
E=257-308 P leading edge cell differentiation
E=257-308 P learning
E=257-308 P liver development
E=257-308 P membrane depolarization
E=257-308 P microglial cell activation
E=257-308 P monocyte differentiation
E=257-308 P negative regulation by host of viral transcription
E=257-308 P negative regulation of cell population proliferation
E=257-308 P negative regulation of DNA binding
E=257-308 P negative regulation of neuron apoptotic process
E=257-308 P negative regulation of protein autophosphorylation
E=257-308 P negative regulation of transcription by RNA polymerase II
E=257-308 P negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
E=257-308 P negative regulation of transcription, DNA-templated
E=257-308 P outflow tract morphogenesis
E=257-308 P positive regulation by host of viral transcription
E=257-308 P positive regulation of apoptotic process
E=257-308 P positive regulation of cell differentiation
E=257-308 P positive regulation of DNA replication
E=257-308 P positive regulation of DNA-templated transcription, initiation
E=257-308 P positive regulation of endothelial cell proliferation
E=257-308 P positive regulation of epithelial cell migration
E=257-308 P positive regulation of ERK1 and ERK2 cascade
E=257-308 P positive regulation of fibroblast proliferation
E=257-308 P positive regulation of monocyte differentiation
E=257-308 P positive regulation of neuron apoptotic process
E=257-308 P positive regulation of pri-miRNA transcription by RNA polymerase II
E=257-308 P positive regulation of transcription by RNA polymerase II
E=257-308 P positive regulation of transcription, DNA-templated
E=257-308 P positive regulation of vascular associated smooth muscle cell proliferation
E=257-308 P Ras protein signal transduction
E=257-308 P regulation of cell cycle
E=257-308 P regulation of cell population proliferation
E=257-308 P regulation of DNA-binding transcription factor activity
E=257-308 P release of cytochrome c from mitochondria
E=257-308 P response to cAMP
E=257-308 P response to cytokine
E=257-308 P response to drug
E=257-308 P response to hydrogen peroxide
E=257-308 P response to lipopolysaccharide
E=257-308 P response to mechanical stimulus
E=257-308 P response to muscle stretch
E=257-308 P response to organic substance
E=257-308 P response to radiation
E=257-308 P SMAD protein signal transduction
E=257-308 P transcription by RNA polymerase II
E=257-308 P transforming growth factor beta receptor signaling pathway
Sequences
Download file with secondary structure created by Stride  
1s9k.pdb1.pdb:   [ download sequences in FASTA format ]
A (dna): 
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B (dna): 
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C (protein): 
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D (protein): 
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E (protein): 
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