General information
PDB ID 1SEU
Title HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE INDOLOCARBAZOLE SA315F AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
PDB header ISOMERASE/DNA
Date 2004-02-18
Experimental method X-RAY DIFFRACTION
Resolution (A) 3
Kind dna
Organism HOMO SAPIENS
Download
complex
View in
Jmol
Quick Links
PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1seu.pdb A BCD 0
Biounits:
1seu.pdb1.pdb A BCD 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Topoisom_I Domain P11387_432-665 2.4e-101 1 CL0382 A 432 665 BD  H-Bb H-Mn L-Bb 
Topoisom_I_N Family P11387_215-429 1.6e-99 1 No_clan A 215 429 BCD  H-Bb S-Bb S-Mj L-Bb L-Mj 
Topo_C_assoc Family P11387_695-765 2.1e-29 1 No_clan A 695 765 CDB  H-Bb 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: Long alpha-hairpin
    Superfamily: Eukaryotic DNA topoisomerase I, dispensable insert domain
      Family: Eukaryotic DNA topoisomerase I, dispensable insert domain
Eukaryotic DNA topoisomerase I, dispensable insert domain A 636 712 -
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core A 431 633 CDB  H-Bb L-Bb 
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core A 431 633 BD  H-Bb L-Bb 
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core A 714 765 CDB  H-Bb 
Class: Alpha and beta proteins (a+b)
  Fold: DNA breaking-rejoining enzymes
    Superfamily: DNA breaking-rejoining enzymes
      Family: Eukaryotic DNA topoisomerase I, catalytic core
Eukaryotic DNA topoisomerase I, catalytic core A 714 765 BD  H-Bb 
Class: Multi-domain proteins (alpha and beta)
  Fold: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
    Superfamily: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
      Family: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment A 201 430 BCD  H-Bb S-Bb S-Mj L-Bb L-Mj 
GO terms
Protein chains: GO type: GO description:
A=174-765 C fibrillar center
A=174-765 C nucleolus
A=174-765 C nucleoplasm
A=174-765 C nucleus
A=174-765 C P-body
A=174-765 C perikaryon
A=174-765 C protein-DNA complex
A=174-765 C replication fork protection complex
A=174-765 F ATP binding
A=174-765 F chromatin binding
A=174-765 F DNA binding
A=174-765 F DNA topoisomerase type I (single strand cut, ATP-independent) activity
A=174-765 F double-stranded DNA binding
A=174-765 F protein domain specific binding
A=174-765 F protein serine/threonine kinase activity
A=174-765 F RNA binding
A=174-765 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A=174-765 F single-stranded DNA binding
A=174-765 F supercoiled DNA binding
A=174-765 P chromatin remodeling
A=174-765 P chromosome segregation
A=174-765 P circadian regulation of gene expression
A=174-765 P circadian rhythm
A=174-765 P DNA replication
A=174-765 P DNA topological change
A=174-765 P embryonic cleavage
A=174-765 P peptidyl-serine phosphorylation
A=174-765 P phosphorylation
A=174-765 P programmed cell death
A=174-765 P response to drug
A=174-765 P viral process
Sequences
Download file with secondary structure created by Stride  
1seu.pdb1.pdb:   [ download sequences in FASTA format ]
B (dna): 
Click "SHOW" for view sequence
C (dna): 
Click "SHOW" for view sequence
D (dna): 
Click "SHOW" for view sequence
A (protein): 
Click "SHOW" for view sequence
© NPIDB team 2003 - 2021

text