General information
PDB ID 1SI3
Title CRYSTAL STRUCTURE OF THE PAZ DOMAIN OF HUMAN EIF2C1 IN COMPLEX WITH A 9-MER SIRNA-LIKE DUPLEX
PDB header GENE REGULATION/RNA
Date 2004-02-27
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.6
Kind rna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
PRIDB
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1si3.pdb A B 0
Biounits:
1si3.pdb1.pdb A B 2
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
PAZ Domain Q9UL18_229-349 3.1e-27 1 CL0638 A 228 349 B   
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All beta proteins
  Fold: SH3-like barrel
    Superfamily: PAZ domain
      Family: PAZ domain
Eukaryotic translation initiation factor 2C 1, EIF2C1 A N/A N/A B -
GO terms
Protein chains: GO type: GO description:
A=225-369 C cytoplasm
A=225-369 C cytosol
A=225-369 C nucleoplasm
A=225-369 C nucleus
A=225-369 C P-body
A=225-369 C polysome
A=225-369 C ribonucleoprotein complex
A=225-369 C RISC complex
A=225-369 C RISC-loading complex
A=225-369 F core promoter sequence-specific DNA binding
A=225-369 F double-stranded RNA binding
A=225-369 F miRNA binding
A=225-369 F RNA binding
A=225-369 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A=225-369 F RNA polymerase II complex binding
A=225-369 F single-stranded RNA binding
A=225-369 P miRNA loading onto RISC involved in gene silencing by miRNA
A=225-369 P miRNA mediated inhibition of translation
A=225-369 P miRNA metabolic process
A=225-369 P negative regulation of angiogenesis
A=225-369 P negative regulation of gene expression
A=225-369 P nuclear-transcribed mRNA catabolic process
A=225-369 P positive regulation of gene expression
A=225-369 P positive regulation of NIK/NF-kappaB signaling
A=225-369 P positive regulation of transcription by RNA polymerase II
A=225-369 P post-transcriptional gene silencing by RNA
A=225-369 P pre-miRNA processing
A=225-369 P production of miRNAs involved in gene silencing by miRNA
A=225-369 P regulation of gene silencing by miRNA
A=225-369 P regulation of megakaryocyte differentiation
A=225-369 P RNA phosphodiester bond hydrolysis, endonucleolytic
A=225-369 P RNA secondary structure unwinding
A=225-369 P Wnt signaling pathway, calcium modulating pathway
Sequences
Download file with secondary structure created by Stride  
1si3.pdb1.pdb:   [ download sequences in FASTA format ]
A (protein): 
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B (rna): 
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