General information
PDB ID 1T05
Title HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO TEMPLATE-PRIMER WITH TENOFOVIR-DIPHOSPHATE BOUND AS THE INCOMING NUCLEOTIDE SUBSTRATE
PDB header TRANSFERASE/DNA
Date 2004-04-07
Experimental method X-RAY DIFFRACTION
Resolution (A) 3
Kind dna
Organism HUMAN IMMUNODEFICIENCY VIRUS 1
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Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1t05.pdb AB TP 0
Biounits:
1t05.pdb1.pdb AB TP 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
RVT_connect Domain P03366_917-1018 2.5e-59 1 No_clan A 318 419   
RVT_1 Domain P03366_662-833 1.1e-34 1 CL0027 A 63 234 PT  H-Bb S-Bb S-Mn L-Bb L-Mn 
RNase_H Domain P03366_1035-1153 2.4e-28 1 CL0219 A 436 554 P  H-Bb 
RVT_thumb Domain P03366_840-903 1.1e-19 1 No_clan A 241 304 TP  H-Bb L-Bb 
RVT_connect Domain P04585_905-1006 1.5e-59 1 No_clan B 318 419 P  H-Bb 
RVT_1 Domain P04585_650-821 3.7e-33 1 CL0027 B 63 243   
RVT_thumb Domain P04585_828-891 1.4e-21 1 No_clan B 241 304   
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: Alpha and beta proteins (a/b)
  Fold: Ribonuclease H-like motif
    Superfamily: Ribonuclease H-like
      Family: Ribonuclease H
HIV RNase H (Domain of reverse transcriptase) A 430 554 P -
Class: Multi-domain proteins (alpha and beta)
  Fold: DNA/RNA polymerases
    Superfamily: DNA/RNA polymerases
      Family: Reverse transcriptase
HIV-1 reverse transcriptase A 1 429 PT -
Class: Multi-domain proteins (alpha and beta)
  Fold: DNA/RNA polymerases
    Superfamily: DNA/RNA polymerases
      Family: Reverse transcriptase
HIV-1 reverse transcriptase B N/A N/A P -
GO terms
Protein chains: GO type: GO description:
A=600-1157 C host cell nucleus
A=600-1157 C host cell plasma membrane
A=600-1157 C host multivesicular body
A=600-1157 C viral nucleocapsid
A=600-1157 C virion membrane
A=600-1157 F aspartic-type endopeptidase activity
A=600-1157 F DNA binding
A=600-1157 F DNA-directed DNA polymerase activity
A=600-1157 F exoribonuclease H activity
A=600-1157 F lipid binding
A=600-1157 F RNA binding
A=600-1157 F RNA-directed DNA polymerase activity
A=600-1157 F RNA-DNA hybrid ribonuclease activity
A=600-1157 F structural molecule activity
A=600-1157 F zinc ion binding
A=600-1157 P DNA integration
A=600-1157 P DNA recombination
A=600-1157 P establishment of integrated proviral latency
A=600-1157 P induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process
A=600-1157 P suppression by virus of host gene expression
A=600-1157 P viral entry into host cell
A=600-1157 P viral genome integration into host DNA
A=600-1157 P viral penetration into host nucleus
B=588-1016 C host cell nucleus
B=588-1016 C host cell plasma membrane
B=588-1016 C host multivesicular body
B=588-1016 C viral nucleocapsid
B=588-1016 C virion membrane
B=588-1016 F aspartic-type endopeptidase activity
B=588-1016 F DNA binding
B=588-1016 F DNA-directed DNA polymerase activity
B=588-1016 F exoribonuclease H activity
B=588-1016 F identical protein binding
B=588-1016 F integrase activity
B=588-1016 F lipid binding
B=588-1016 F peptidase activity
B=588-1016 F RNA binding
B=588-1016 F RNA-directed DNA polymerase activity
B=588-1016 F RNA-DNA hybrid ribonuclease activity
B=588-1016 F structural molecule activity
B=588-1016 F zinc ion binding
B=588-1016 P DNA recombination
B=588-1016 P establishment of integrated proviral latency
B=588-1016 P fusion of virus membrane with host plasma membrane
B=588-1016 P induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process
B=588-1016 P nuclear transport
B=588-1016 P RNA-dependent DNA biosynthetic process
B=588-1016 P suppression by virus of host gene expression
B=588-1016 P uncoating of virus
B=588-1016 P viral genome integration into host DNA
B=588-1016 P viral genome packaging
B=588-1016 P viral life cycle
B=588-1016 P viral penetration into host nucleus
B=588-1016 P virion assembly
Sequences
Download file with secondary structure created by Stride  
1t05.pdb1.pdb:   [ download sequences in FASTA format ]
P (dna): 
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T (dna): 
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A (protein): 
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B (protein): 
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