General information
PDB ID 1T2K
Title STRUCTURE OF THE DNA BINDING DOMAINS OF IRF3, ATF-2 AND JUN BOUND TO DNA
PDB header TRANSCRIPTION/DNA
Date 2004-04-21
Experimental method X-RAY DIFFRACTION
Resolution (A) 3
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1t2k.pdb ABCD EF 0
Biounits:
1t2k.pdb1.pdb ABCD EF 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
bZIP_1 Coiled-coil P05412_256-313 5.4e-18 1 CL0018 C 253 313 E  H-Bb H-Mj 
ZapB Coiled-coil P05412_273-309 0.00055 0 CL0225 C 267 312   
bZIP_1 Coiled-coil P15336_354-413 5.5e-13 1 CL0018 D 336 395 EF  H-Bb H-Mj 
IRF Domain Q14653_7-110 3.4e-35 1 CL0123 A 7 110 EF  H-Bb H-Mj L-Bb L-Mn 
IRF Domain Q14653_7-110 3.1e-35 1 CL0123 B 7 110 EF  H-Bb H-Mj L-Bb L-Mn 
PspA_IM30 Family P05412_273-311 0.00048 0 CL0235 C 271 314   
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: Interferon regulatory factor
Interferon regulatory factor 3, IRF-3 A N/A N/A EF  H-Bb H-Mj L-Bb 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: Interferon regulatory factor
Interferon regulatory factor 3, IRF-3 B N/A N/A EF  H-Bb H-Mj L-Bb 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
Cyclic-AMP-dependent transcription factor ATF-2 D N/A N/A EF  H-Bb H-Mj 
Class: Coiled coil proteins
  Fold: Parallel coiled-coil
    Superfamily: Leucine zipper domain
      Family: Leucine zipper domain
C-jun C N/A N/A E  H-Bb H-Mj 
GO terms
Protein chains: GO type: GO description:
A/B=1-112 C cytoplasm
A/B=1-112 C cytosol
A/B=1-112 C nuclear chromatin
A/B=1-112 C nucleoplasm
A/B=1-112 C nucleus
A/B=1-112 F DNA binding
A/B=1-112 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/B=1-112 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/B=1-112 F DNA-binding transcription repressor activity, RNA polymerase II-specific
A/B=1-112 F identical protein binding
A/B=1-112 F protein domain specific binding
A/B=1-112 F protein homodimerization activity
A/B=1-112 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/B=1-112 F sequence-specific DNA binding
A/B=1-112 F sequence-specific double-stranded DNA binding
A/B=1-112 P apoptotic process
A/B=1-112 P cellular response to DNA damage stimulus
A/B=1-112 P cellular response to exogenous dsRNA
A/B=1-112 P defense response to virus
A/B=1-112 P immune system process
A/B=1-112 P interferon-gamma-mediated signaling pathway
A/B=1-112 P lipopolysaccharide-mediated signaling pathway
A/B=1-112 P macrophage apoptotic process
A/B=1-112 P MDA-5 signaling pathway
A/B=1-112 P negative regulation of type I interferon production
A/B=1-112 P positive regulation of cytokine secretion
A/B=1-112 P positive regulation of I-kappaB kinase/NF-kappaB signaling
A/B=1-112 P positive regulation of interferon-alpha production
A/B=1-112 P positive regulation of interferon-beta production
A/B=1-112 P positive regulation of transcription by RNA polymerase II
A/B=1-112 P positive regulation of type I interferon production
A/B=1-112 P positive regulation of type I interferon-mediated signaling pathway
A/B=1-112 P programmed necrotic cell death
A/B=1-112 P regulation of inflammatory response
A/B=1-112 P regulation of type I interferon production
A/B=1-112 P TRIF-dependent toll-like receptor signaling pathway
A/B=1-112 P type I interferon production
A/B=1-112 P type I interferon signaling pathway
A/B=1-112 P viral process
C=254-314 C cytosol
C=254-314 C nuclear chromatin
C=254-314 C nuclear chromosome
C=254-314 C nuclear euchromatin
C=254-314 C nucleoplasm
C=254-314 C nucleus
C=254-314 C transcription factor AP-1 complex
C=254-314 C transcription regulator complex
C=254-314 C transcription repressor complex
C=254-314 F cAMP response element binding
C=254-314 F chromatin binding
C=254-314 F DNA binding
C=254-314 F DNA-binding transcription activator activity, RNA polymerase II-specific
C=254-314 F DNA-binding transcription factor activity
C=254-314 F DNA-binding transcription factor activity, RNA polymerase II-specific
C=254-314 F DNA-binding transcription repressor activity, RNA polymerase II-specific
C=254-314 F enzyme binding
C=254-314 F GTPase activator activity
C=254-314 F HMG box domain binding
C=254-314 F identical protein binding
C=254-314 F protein-containing complex binding
C=254-314 F R-SMAD binding
C=254-314 F RNA binding
C=254-314 F RNA polymerase II activating transcription factor binding
C=254-314 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
C=254-314 F sequence-specific double-stranded DNA binding
C=254-314 F transcription coactivator activity
C=254-314 F transcription factor binding
C=254-314 F transcription regulatory region sequence-specific DNA binding
C=254-314 F ubiquitin protein ligase binding
C=254-314 F ubiquitin-like protein ligase binding
C=254-314 P aging
C=254-314 P angiogenesis
C=254-314 P axon regeneration
C=254-314 P cellular response to cadmium ion
C=254-314 P cellular response to calcium ion
C=254-314 P cellular response to hormone stimulus
C=254-314 P cellular response to potassium ion starvation
C=254-314 P cellular response to reactive oxygen species
C=254-314 P circadian rhythm
C=254-314 P eyelid development in camera-type eye
C=254-314 P Fc-epsilon receptor signaling pathway
C=254-314 P leading edge cell differentiation
C=254-314 P learning
C=254-314 P liver development
C=254-314 P membrane depolarization
C=254-314 P microglial cell activation
C=254-314 P monocyte differentiation
C=254-314 P negative regulation by host of viral transcription
C=254-314 P negative regulation of cell population proliferation
C=254-314 P negative regulation of DNA binding
C=254-314 P negative regulation of neuron apoptotic process
C=254-314 P negative regulation of protein autophosphorylation
C=254-314 P negative regulation of transcription by RNA polymerase II
C=254-314 P negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
C=254-314 P negative regulation of transcription, DNA-templated
C=254-314 P outflow tract morphogenesis
C=254-314 P positive regulation by host of viral transcription
C=254-314 P positive regulation of apoptotic process
C=254-314 P positive regulation of cell differentiation
C=254-314 P positive regulation of DNA replication
C=254-314 P positive regulation of DNA-templated transcription, initiation
C=254-314 P positive regulation of endothelial cell proliferation
C=254-314 P positive regulation of epithelial cell migration
C=254-314 P positive regulation of ERK1 and ERK2 cascade
C=254-314 P positive regulation of fibroblast proliferation
C=254-314 P positive regulation of monocyte differentiation
C=254-314 P positive regulation of neuron apoptotic process
C=254-314 P positive regulation of pri-miRNA transcription by RNA polymerase II
C=254-314 P positive regulation of transcription by RNA polymerase II
C=254-314 P positive regulation of transcription, DNA-templated
C=254-314 P positive regulation of vascular associated smooth muscle cell proliferation
C=254-314 P Ras protein signal transduction
C=254-314 P regulation of cell cycle
C=254-314 P regulation of cell population proliferation
C=254-314 P regulation of DNA-binding transcription factor activity
C=254-314 P release of cytochrome c from mitochondria
C=254-314 P response to cAMP
C=254-314 P response to cytokine
C=254-314 P response to drug
C=254-314 P response to hydrogen peroxide
C=254-314 P response to lipopolysaccharide
C=254-314 P response to mechanical stimulus
C=254-314 P response to muscle stretch
C=254-314 P response to organic substance
C=254-314 P response to radiation
C=254-314 P SMAD protein signal transduction
C=254-314 P transcription by RNA polymerase II
C=254-314 P transforming growth factor beta receptor signaling pathway
D=354-414 C cytoplasm
D=354-414 C mitochondrial outer membrane
D=354-414 C nuclear chromatin
D=354-414 C nucleoplasm
D=354-414 C nucleus
D=354-414 C site of double-strand break
D=354-414 F cAMP response element binding
D=354-414 F cAMP response element binding protein binding
D=354-414 F chromatin binding
D=354-414 F cis-regulatory region sequence-specific DNA binding
D=354-414 F DNA-binding transcription activator activity, RNA polymerase II-specific
D=354-414 F DNA-binding transcription factor activity
D=354-414 F DNA-binding transcription factor activity, RNA polymerase II-specific
D=354-414 F histone acetyltransferase activity
D=354-414 F metal ion binding
D=354-414 F protein kinase binding
D=354-414 F protein-containing complex binding
D=354-414 F RNA polymerase II activating transcription factor binding
D=354-414 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
D=354-414 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
D=354-414 F sequence-specific double-stranded DNA binding
D=354-414 P adipose tissue development
D=354-414 P amelogenesis
D=354-414 P cellular response to DNA damage stimulus
D=354-414 P fat cell differentiation
D=354-414 P intra-S DNA damage checkpoint
D=354-414 P negative regulation of angiogenesis
D=354-414 P negative regulation of epithelial cell proliferation
D=354-414 P negative regulation of transcription by RNA polymerase II
D=354-414 P outflow tract morphogenesis
D=354-414 P positive regulation of cardiac muscle myoblast proliferation
D=354-414 P positive regulation of DNA-binding transcription factor activity
D=354-414 P positive regulation of gene expression
D=354-414 P positive regulation of mitochondrial membrane permeability involved in apoptotic process
D=354-414 P positive regulation of neuron apoptotic process
D=354-414 P positive regulation of transcription by RNA polymerase II
D=354-414 P positive regulation of transforming growth factor beta2 production
D=354-414 P regulation of DNA-binding transcription factor activity
D=354-414 P regulation of transcription by RNA polymerase II
D=354-414 P regulation of transcription, DNA-templated
D=354-414 P response to osmotic stress
D=354-414 P response to water deprivation
Sequences
Download file with secondary structure created by Stride  
1t2k.pdb1.pdb:   [ download sequences in FASTA format ]
E (dna): 
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F (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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D (protein): 
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