General information
PDB ID 1TQE
Title MECHANISM OF RECRUITMENT OF CLASS II HISTONE DEACETYLASES BY MYOCYTE ENHANCER FACTOR-2
PDB header TRANSCRIPTION/PROTEIN BINDING/DNA
Date 2004-06-17
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.7
Kind dna
Organism HOMO SAPIENS, MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb1tqe.pdb PQXRSY CDEF 0
Biounits:
1tqe.pdb1.pdb PQX CD 1
1tqe.pdb2.pdb RSY EF 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
SRF-TF Domain Q02080_10-57 2.3e-24 1 No_clan P 10 57 CD  H-Bb H-Mj 
SRF-TF Domain Q02080_10-57 2.3e-24 1 No_clan Q 10 57 D  H-Bb H-Mj 
SRF-TF Domain Q02080_10-57 2.3e-24 1 No_clan R 10 57 EF  H-Bb H-Mj 
SRF-TF Domain Q02080_10-57 2.3e-24 1 No_clan S 10 57 F  H-Bb H-Mj 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: Alpha and beta proteins (a+b)
  Fold: SRF-like
    Superfamily: SRF-like
      Family: SRF-like
Myocyte enhancer factor Mef2b core P N/A N/A CD  H-Bb H-Mj L-Bb L-Mn 
Class: Alpha and beta proteins (a+b)
  Fold: SRF-like
    Superfamily: SRF-like
      Family: SRF-like
Myocyte enhancer factor Mef2b core Q N/A N/A CD  H-Bb H-Mj L-Bb L-Mn 
Class: Alpha and beta proteins (a+b)
  Fold: SRF-like
    Superfamily: SRF-like
      Family: SRF-like
Myocyte enhancer factor Mef2b core R N/A N/A EF  H-Bb H-Mj L-Bb L-Mn 
Class: Alpha and beta proteins (a+b)
  Fold: SRF-like
    Superfamily: SRF-like
      Family: SRF-like
Myocyte enhancer factor Mef2b core S N/A N/A EF  H-Bb H-Mj L-Bb L-Mn 
GO terms
Protein chains: GO type: GO description:
P/Q/R/S=1-93 C cell junction
P/Q/R/S=1-93 C cytosol
P/Q/R/S=1-93 C nuclear chromatin
P/Q/R/S=1-93 C nucleoplasm
P/Q/R/S=1-93 C nucleus
P/Q/R/S=1-93 C transcription regulator complex
P/Q/R/S=1-93 F DNA-binding transcription activator activity, RNA polymerase II-specific
P/Q/R/S=1-93 F DNA-binding transcription factor activity
P/Q/R/S=1-93 F DNA-binding transcription factor activity, RNA polymerase II-specific
P/Q/R/S=1-93 F histone deacetylase binding
P/Q/R/S=1-93 F protein dimerization activity
P/Q/R/S=1-93 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
P/Q/R/S=1-93 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
P/Q/R/S=1-93 F sequence-specific DNA binding
P/Q/R/S=1-93 F sequence-specific double-stranded DNA binding
P/Q/R/S=1-93 F transcription factor binding
P/Q/R/S=1-93 F transcription regulatory region sequence-specific DNA binding
P/Q/R/S=1-93 P cell differentiation
P/Q/R/S=1-93 P muscle organ development
P/Q/R/S=1-93 P positive regulation of transcription by RNA polymerase II
X/Y=139-158 C cytoplasm
X/Y=139-158 C histone deacetylase complex
X/Y=139-158 C histone methyltransferase complex
X/Y=139-158 C nucleus
X/Y=139-158 C transcription regulator complex
X/Y=139-158 F histone deacetylase activity
X/Y=139-158 F histone deacetylase activity (H4-K16 specific)
X/Y=139-158 F histone deacetylase binding
X/Y=139-158 F protein deacetylase activity
X/Y=139-158 F protein kinase C binding
X/Y=139-158 F repressing transcription factor binding
X/Y=139-158 F transcription corepressor activity
X/Y=139-158 F transcription factor binding
X/Y=139-158 P B cell activation
X/Y=139-158 P B cell differentiation
X/Y=139-158 P cellular response to insulin stimulus
X/Y=139-158 P cholesterol homeostasis
X/Y=139-158 P chromatin organization
X/Y=139-158 P determination of adult lifespan
X/Y=139-158 P DNA repair
X/Y=139-158 P heart development
X/Y=139-158 P histone deacetylation
X/Y=139-158 P histone H3 deacetylation
X/Y=139-158 P histone H4 deacetylation
X/Y=139-158 P histone H4-K16 deacetylation
X/Y=139-158 P inflammatory response
X/Y=139-158 P negative regulation of cytokine secretion
X/Y=139-158 P negative regulation of lipoprotein lipase activity
X/Y=139-158 P negative regulation of striated muscle tissue development
X/Y=139-158 P negative regulation of transcription by RNA polymerase II
X/Y=139-158 P negative regulation of transcription, DNA-templated
X/Y=139-158 P nervous system development
X/Y=139-158 P peptidyl-lysine deacetylation
X/Y=139-158 P positive regulation of cell migration involved in sprouting angiogenesis
X/Y=139-158 P regulation of skeletal muscle fiber development
X/Y=139-158 P regulation of striated muscle cell differentiation
Sequences
Download file with secondary structure created by Stride  
1tqe.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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P (protein): 
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Q (protein): 
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X (protein): 
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1tqe.pdb2.pdb:   [ download sequences in FASTA format ]
E (dna): 
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F (dna): 
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R (protein): 
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S (protein): 
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Y (protein): 
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