General information
PDB ID 2HAN
Title STRUCTURAL BASIS OF HETERODIMERIC ECDYSTEROID RECEPTOR INTERACTION WITH NATURAL RESPONSE ELEMENT HSP27 GENE PROMOTER
PDB header TRANSCRIPTION/DNA
Date 2006-06-13
Experimental method X-RAY DIFFRACTION
Resolution (A) 1.95
Kind dna
Organism DROSOPHILA MELANOGASTER
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
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Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb2han.pdb AB CD 0
Biounits:
2han.pdb1.pdb AB CD 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
zf-C4 Domain P20153_102-171 2e-32 1 CL0167 A 5 74 CD  H-Bb H-Mj S-Bb S-Mj L-Bb 
zf-C4 Domain P34021_262-331 1.7e-30 1 CL0167 B 5 74 CD  H-Bb H-Mj H-Mn S-Bb L-Bb L-Mj 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: Small proteins
  Fold: Glucocorticoid receptor-like (DNA-binding domain)
    Superfamily: Glucocorticoid receptor-like (DNA-binding domain)
      Family: Nuclear receptor
Ecdysone receptor DNA-binding domain B 5 87 CD  H-Bb H-Mj S-Bb L-Bb 
Class: Small proteins
  Fold: Glucocorticoid receptor-like (DNA-binding domain)
    Superfamily: Glucocorticoid receptor-like (DNA-binding domain)
      Family: Nuclear receptor
Retinoid X receptor (RXR-alpha) DNA-binding domain A 7 72 CD  H-Bb H-Mj S-Bb L-Bb 
GO terms
Protein chains: GO type: GO description:
A=94-179 C activator ecdysone receptor complex
A=94-179 C dendrite
A=94-179 C ecdysone receptor holocomplex
A=94-179 C nucleus
A=94-179 C polytene chromosome
A=94-179 C RNA polymerase II transcription regulator complex
A=94-179 F core promoter sequence-specific DNA binding
A=94-179 F DNA binding
A=94-179 F DNA-binding transcription factor activity
A=94-179 F hormone binding
A=94-179 F lipid binding
A=94-179 F nuclear receptor activity
A=94-179 F protein heterodimerization activity
A=94-179 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
A=94-179 F signaling receptor binding
A=94-179 F steroid hormone receptor activity
A=94-179 F transcription regulatory region sequence-specific DNA binding
A=94-179 F zinc ion binding
A=94-179 P anatomical structure development
A=94-179 P border follicle cell migration
A=94-179 P cell differentiation
A=94-179 P cellular response to ecdysone
A=94-179 P dendrite morphogenesis
A=94-179 P ecdysone biosynthetic process
A=94-179 P germ cell development
A=94-179 P metamorphosis
A=94-179 P mushroom body development
A=94-179 P negative regulation of cell differentiation
A=94-179 P negative regulation of transcription, DNA-templated
A=94-179 P neuron remodeling
A=94-179 P positive regulation of transcription by RNA polymerase II
A=94-179 P positive regulation of transcription, DNA-templated
A=94-179 P pupariation
A=94-179 P regulation of development, heterochronic
A=94-179 P regulation of organ growth
A=94-179 P regulation of transcription by RNA polymerase II
A=94-179 P response to ecdysone
A=94-179 P response to starvation
B=256-365 C activator ecdysone receptor complex
B=256-365 C cytoplasm
B=256-365 C dendrite
B=256-365 C ecdysone receptor holocomplex
B=256-365 C nucleus
B=256-365 C polytene chromosome
B=256-365 C repressor ecdysone receptor complex
B=256-365 C RNA polymerase II transcription regulator complex
B=256-365 F core promoter sequence-specific DNA binding
B=256-365 F DNA binding
B=256-365 F DNA-binding transcription activator activity, RNA polymerase II-specific
B=256-365 F DNA-binding transcription factor activity, RNA polymerase II-specific
B=256-365 F ecdysone binding
B=256-365 F nuclear receptor activity
B=256-365 F protein heterodimerization activity
B=256-365 F protein homodimerization activity
B=256-365 F repressing transcription factor binding
B=256-365 F RNA polymerase II transcription coactivator binding
B=256-365 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
B=256-365 F signaling receptor activity
B=256-365 F signaling receptor binding
B=256-365 F steroid binding
B=256-365 F transcription factor binding
B=256-365 F transcription regulatory region sequence-specific DNA binding
B=256-365 F zinc ion binding
B=256-365 P autophagy
B=256-365 P border follicle cell migration
B=256-365 P cardiac muscle tissue development
B=256-365 P cardioblast differentiation
B=256-365 P cell adhesion
B=256-365 P cell differentiation
B=256-365 P chitin-based cuticle development
B=256-365 P chitin-based embryonic cuticle biosynthetic process
B=256-365 P cholesterol homeostasis
B=256-365 P dendrite morphogenesis
B=256-365 P determination of adult lifespan
B=256-365 P dorsal vessel heart proper cell fate commitment
B=256-365 P ecdysis, chitin-based cuticle
B=256-365 P ecdysone receptor-mediated signaling pathway
B=256-365 P ecdysone-mediated induction of salivary gland cell autophagic cell death
B=256-365 P epidermis development
B=256-365 P germ cell development
B=256-365 P germ-band shortening
B=256-365 P hatching
B=256-365 P head involution
B=256-365 P histoblast morphogenesis
B=256-365 P imaginal disc-derived wing morphogenesis
B=256-365 P larval central nervous system remodeling
B=256-365 P larval development
B=256-365 P larval wandering behavior
B=256-365 P lipid homeostasis
B=256-365 P lipid metabolic process
B=256-365 P long-term memory
B=256-365 P Malpighian tubule morphogenesis
B=256-365 P metamorphosis
B=256-365 P mushroom body development
B=256-365 P negative regulation of transcription by RNA polymerase II
B=256-365 P negative regulation of transcription, DNA-templated
B=256-365 P neuron remodeling
B=256-365 P oogenesis
B=256-365 P peripheral nervous system development
B=256-365 P phagocytosis, engulfment
B=256-365 P positive regulation of apoptotic process
B=256-365 P positive regulation of circadian sleep/wake cycle, sleep
B=256-365 P positive regulation of neuron remodeling
B=256-365 P positive regulation of transcription by RNA polymerase II
B=256-365 P positive regulation of transcription, DNA-templated
B=256-365 P pupariation
B=256-365 P regulation of autophagy
B=256-365 P regulation of cellular respiration
B=256-365 P regulation of development, heterochronic
B=256-365 P regulation of hemocyte proliferation
B=256-365 P regulation of Malpighian tubule diameter
B=256-365 P regulation of neuron remodeling
B=256-365 P regulation of rhodopsin gene expression
B=256-365 P regulation of transcription by RNA polymerase II
B=256-365 P response to cocaine
B=256-365 P response to ecdysone
B=256-365 P salivary gland cell autophagic cell death
B=256-365 P sperm individualization
Sequences
Download file with secondary structure created by Stride  
2han.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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A (protein): 
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B (protein): 
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