General information
PDB ID 2NLL
Title RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA
PDB header TRANSCRIPTION/DNA
Date 1996-11-20
Experimental method X-RAY DIFFRACTION
Resolution (A) 1.9
Kind dna
Organism HOMO SAPIENS
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CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb2nll.pdb AB CD 0
Biounits:
2nll.pdb1.pdb AB CD 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
zf-C4 Domain P19793_133-202 1.3e-32 1 CL0167 A 135 200 CD  H-Bb H-Mj S-Bb L-Bb 
zf-C4 Domain P10828_105-176 1.7e-31 1 CL0167 B 301 372 CD  H-Bb H-Mj S-Bb L-Bb L-Mj 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: Small proteins
  Fold: Glucocorticoid receptor-like (DNA-binding domain)
    Superfamily: Glucocorticoid receptor-like (DNA-binding domain)
      Family: Nuclear receptor
Retinoid X receptor (RXR-alpha) DNA-binding domain A N/A N/A CD  H-Bb H-Mj S-Bb L-Bb 
Class: Small proteins
  Fold: Glucocorticoid receptor-like (DNA-binding domain)
    Superfamily: Glucocorticoid receptor-like (DNA-binding domain)
      Family: Nuclear receptor
Thyroid hormone receptor (TR-beta) DNA-binding domain B N/A N/A CD  H-Bb H-Mj H-Mn L-Bb 
GO terms
Protein chains: GO type: GO description:
A=135-200 C mitochondrion
A=135-200 C nuclear chromatin
A=135-200 C nucleoplasm
A=135-200 C nucleus
A=135-200 C protein-containing complex
A=135-200 C receptor complex
A=135-200 C RNA polymerase II transcription regulator complex
A=135-200 F chromatin DNA binding
A=135-200 F DNA binding domain binding
A=135-200 F DNA-binding transcription factor activity
A=135-200 F DNA-binding transcription factor activity, RNA polymerase II-specific
A=135-200 F double-stranded DNA binding
A=135-200 F enzyme binding
A=135-200 F identical protein binding
A=135-200 F LBD domain binding
A=135-200 F nuclear receptor activity
A=135-200 F nuclear receptor binding
A=135-200 F peptide binding
A=135-200 F retinoic acid binding
A=135-200 F retinoic acid-responsive element binding
A=135-200 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A=135-200 F RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
A=135-200 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
A=135-200 F sequence-specific DNA binding
A=135-200 F sequence-specific double-stranded DNA binding
A=135-200 F steroid hormone receptor activity
A=135-200 F transcription regulatory region sequence-specific DNA binding
A=135-200 F vitamin D receptor binding
A=135-200 F zinc ion binding
A=135-200 P anatomical structure development
A=135-200 P bile acid and bile salt transport
A=135-200 P camera-type eye development
A=135-200 P cardiac muscle cell proliferation
A=135-200 P cell differentiation
A=135-200 P cholesterol metabolic process
A=135-200 P embryo implantation
A=135-200 P in utero embryonic development
A=135-200 P maternal placenta development
A=135-200 P modulation by virus of host process
A=135-200 P negative regulation of transcription by RNA polymerase II
A=135-200 P peroxisome proliferator activated receptor signaling pathway
A=135-200 P positive regulation of transcription by RNA polymerase II
A=135-200 P positive regulation of transcription, DNA-templated
A=135-200 P positive regulation of translational initiation by iron
A=135-200 P regulation of branching involved in prostate gland morphogenesis
A=135-200 P regulation of lipid metabolic process
A=135-200 P regulation of transcription by RNA polymerase II
A=135-200 P response to retinoic acid
A=135-200 P retinoic acid receptor signaling pathway
A=135-200 P secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
A=135-200 P transcription initiation from RNA polymerase II promoter
A=135-200 P ventricular cardiac muscle cell differentiation
A=135-200 P ventricular cardiac muscle tissue morphogenesis
B=104-204 C host cell nucleus
B=104-204 C nuclear body
B=104-204 C nuclear chromatin
B=104-204 C nucleoplasm
B=104-204 C nucleus
B=104-204 C RNA polymerase II transcription regulator complex
B=104-204 F chromatin DNA binding
B=104-204 F DNA binding
B=104-204 F DNA-binding transcription factor activity
B=104-204 F DNA-binding transcription factor activity, RNA polymerase II-specific
B=104-204 F enzyme binding
B=104-204 F nuclear receptor activity
B=104-204 F RNA polymerase II transcription coactivator binding
B=104-204 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
B=104-204 F sequence-specific double-stranded DNA binding
B=104-204 F signaling receptor activity
B=104-204 F thyroid hormone binding
B=104-204 F transcription factor binding
B=104-204 F zinc ion binding
B=104-204 P cell differentiation
B=104-204 P cellular response to thyroid hormone stimulus
B=104-204 P female courtship behavior
B=104-204 P hormone-mediated signaling pathway
B=104-204 P negative regulation of eye photoreceptor cell development
B=104-204 P negative regulation of female receptivity
B=104-204 P negative regulation of transcription by RNA polymerase II
B=104-204 P positive regulation of transcription by RNA polymerase II
B=104-204 P regulation of heart contraction
B=104-204 P retinal cone cell apoptotic process
B=104-204 P retinal cone cell development
B=104-204 P sensory perception of sound
B=104-204 P thyroid hormone mediated signaling pathway
B=104-204 P transcription initiation from RNA polymerase II promoter
B=104-204 P transcription, DNA-templated
B=104-204 P type I pneumocyte differentiation
Sequences
Download file with secondary structure created by Stride  
2nll.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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A (protein): 
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B (protein): 
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