General information
PDB ID 2PI0
Title CRYSTAL STRUCTURE OF IRF-3 BOUND TO THE PRDIII-I REGULATORY ELEMENT OF THE HUMAN INTERFERON-B ENHANCER
PDB header TRANSCRIPTION ACTIVATOR/DNA
Date 2007-04-12
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.31
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb2pi0.pdb ABCD EF 0
Biounits:
2pi0.pdb1.pdb ABCD EF 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
IRF Domain Q14653_7-110 5.1e-28 1 CL0123 A 7 110 EF  H-Bb H-Mj S-Bb L-Bb L-Mn 
IRF Domain Q14653_7-110 3.6e-35 1 CL0123 B 7 110 EF  H-Bb H-Mj S-Bb L-Bb L-Mn 
IRF Domain Q14653_7-110 3e-35 1 CL0123 C 7 110 EF  H-Bb H-Mj S-Bb L-Bb L-Mn 
IRF Domain Q14653_7-110 2.8e-31 1 CL0123 D 7 110 EF  H-Bb H-Mj S-Bb L-Bb L-Mn 
SCOP domains
Classification: Protein: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: Interferon regulatory factor
Interferon regulatory factor 3, IRF-3 A 5 110 EF  H-Bb H-Mj S-Bb L-Bb 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: Interferon regulatory factor
Interferon regulatory factor 3, IRF-3 B 3 112 EF  H-Bb H-Mj S-Bb L-Bb L-Mn 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: Interferon regulatory factor
Interferon regulatory factor 3, IRF-3 C 4 110 EF  H-Bb H-Mj S-Bb L-Bb L-Mn 
Class: All alpha proteins
  Fold: DNA/RNA-binding 3-helical bundle
    Superfamily: "Winged helix" DNA-binding domain
      Family: Interferon regulatory factor
Interferon regulatory factor 3, IRF-3 D 3 111 EF  H-Bb H-Mj S-Bb L-Bb 
GO terms
Protein chains: GO type: GO description:
A/B/C/D=1-113 C cytoplasm
A/B/C/D=1-113 C cytosol
A/B/C/D=1-113 C nuclear chromatin
A/B/C/D=1-113 C nucleoplasm
A/B/C/D=1-113 C nucleus
A/B/C/D=1-113 F DNA binding
A/B/C/D=1-113 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/B/C/D=1-113 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/B/C/D=1-113 F DNA-binding transcription repressor activity, RNA polymerase II-specific
A/B/C/D=1-113 F identical protein binding
A/B/C/D=1-113 F protein domain specific binding
A/B/C/D=1-113 F protein homodimerization activity
A/B/C/D=1-113 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/B/C/D=1-113 F sequence-specific DNA binding
A/B/C/D=1-113 F sequence-specific double-stranded DNA binding
A/B/C/D=1-113 P apoptotic process
A/B/C/D=1-113 P cellular response to DNA damage stimulus
A/B/C/D=1-113 P cellular response to exogenous dsRNA
A/B/C/D=1-113 P defense response to virus
A/B/C/D=1-113 P immune system process
A/B/C/D=1-113 P interferon-gamma-mediated signaling pathway
A/B/C/D=1-113 P lipopolysaccharide-mediated signaling pathway
A/B/C/D=1-113 P macrophage apoptotic process
A/B/C/D=1-113 P MDA-5 signaling pathway
A/B/C/D=1-113 P negative regulation of type I interferon production
A/B/C/D=1-113 P positive regulation of cytokine secretion
A/B/C/D=1-113 P positive regulation of I-kappaB kinase/NF-kappaB signaling
A/B/C/D=1-113 P positive regulation of interferon-alpha production
A/B/C/D=1-113 P positive regulation of interferon-beta production
A/B/C/D=1-113 P positive regulation of transcription by RNA polymerase II
A/B/C/D=1-113 P positive regulation of type I interferon production
A/B/C/D=1-113 P positive regulation of type I interferon-mediated signaling pathway
A/B/C/D=1-113 P programmed necrotic cell death
A/B/C/D=1-113 P regulation of inflammatory response
A/B/C/D=1-113 P regulation of type I interferon production
A/B/C/D=1-113 P TRIF-dependent toll-like receptor signaling pathway
A/B/C/D=1-113 P type I interferon production
A/B/C/D=1-113 P type I interferon signaling pathway
A/B/C/D=1-113 P viral process
Sequences
Download file with secondary structure created by Stride  
2pi0.pdb1.pdb:   [ download sequences in FASTA format ]
E (dna): 
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F (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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D (protein): 
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