General information
PDB ID 2QL2
Title CRYSTAL STRUCTURE OF THE BASIC-HELIX-LOOP-HELIX DOMAINS OF THE HETERODIMER E47/NEUROD1 BOUND TO DNA
PDB header TRANSCRIPTION/DNA
Date 2007-07-12
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.5
Kind dna
Organism MUS MUSCULUS
Download
complex
View in
Jmol
Quick Links
PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb2ql2.pdb ABCD EFGH 0
Biounits:
2ql2.pdb1.pdb AB EF 1
2ql2.pdb2.pdb CD GH 1
2ql2.pdb3.pdb ABCD EFGH 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
HLH Domain P15806_547-600 1.1e-09 1 No_clan A 543 596 EF  H-Bb H-Mj L-Bb 
HLH Domain P15806_547-600 1.1e-09 1 No_clan A 543 596 EF  H-Bb H-Mj L-Bb 
HLH Domain P15806_547-600 1.1e-09 1 No_clan A 543 596 EF  H-Bb H-Mj L-Bb 
HLH Domain P15806_547-600 1.1e-09 1 No_clan A 543 596 EF  H-Bb H-Mj L-Bb 
HLH Domain Q60867_102-154 8.8e-17 1 No_clan B 102 154 EF  H-Bb H-Mj L-Bb 
HLH Domain Q60867_102-154 8.8e-17 1 No_clan B 102 154 EF  H-Bb H-Mj L-Bb 
HLH Domain Q60867_102-154 8.8e-17 1 No_clan B 102 154 EF  H-Bb H-Mj L-Bb 
HLH Domain Q60867_102-154 8.8e-17 1 No_clan B 102 154 EF  H-Bb H-Mj L-Bb 
HLH Domain P15806_547-600 1.5e-10 1 No_clan C 543 596 HG  H-Bb H-Mj 
HLH Domain P15806_547-600 1.5e-10 1 No_clan C 543 596 HG  H-Bb H-Mj 
HLH Domain P15806_547-600 1.5e-10 1 No_clan C 543 596 HG  H-Bb H-Mj 
HLH Domain P15806_547-600 1.5e-10 1 No_clan C 543 596 HG  H-Bb H-Mj 
HLH Domain Q60867_102-154 7.7e-17 1 No_clan D 102 154 G  H-Bb H-Mj 
HLH Domain Q60867_102-154 7.7e-17 1 No_clan D 102 154 G  H-Bb H-Mj 
HLH Domain Q60867_102-154 7.7e-17 1 No_clan D 102 154 G  H-Bb H-Mj 
HLH Domain Q60867_102-154 7.7e-17 1 No_clan D 102 154 G  H-Bb H-Mj 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/C=547-606 C cytoplasm
A/C=547-606 C nuclear chromatin
A/C=547-606 C nuclear euchromatin
A/C=547-606 C nuclear nucleosome
A/C=547-606 C nucleoplasm
A/C=547-606 C nucleus
A/C=547-606 C protein-containing complex
A/C=547-606 C RNA polymerase II transcription regulator complex
A/C=547-606 C transcription regulator complex
A/C=547-606 F bHLH transcription factor binding
A/C=547-606 F chromatin binding
A/C=547-606 F cis-regulatory region sequence-specific DNA binding
A/C=547-606 F DNA binding
A/C=547-606 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/C=547-606 F DNA-binding transcription factor activity
A/C=547-606 F DNA-binding transcription repressor activity, RNA polymerase II-specific
A/C=547-606 F E-box binding
A/C=547-606 F mitogen-activated protein kinase kinase kinase binding
A/C=547-606 F PDZ domain binding
A/C=547-606 F protein heterodimerization activity
A/C=547-606 F protein homodimerization activity
A/C=547-606 F repressing transcription factor binding
A/C=547-606 F RNA polymerase II activating transcription factor binding
A/C=547-606 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/C=547-606 F sequence-specific DNA binding
A/C=547-606 F transcription factor binding
A/C=547-606 F vitamin D response element binding
A/C=547-606 P B cell lineage commitment
A/C=547-606 P cell development
A/C=547-606 P gastrulation
A/C=547-606 P histone H3 acetylation
A/C=547-606 P histone H4 acetylation
A/C=547-606 P immunoglobulin V(D)J recombination
A/C=547-606 P lymphocyte differentiation
A/C=547-606 P natural killer cell differentiation
A/C=547-606 P negative regulation of transcription by RNA polymerase II
A/C=547-606 P Peyer's patch development
A/C=547-606 P positive regulation of B cell proliferation
A/C=547-606 P positive regulation of cell cycle
A/C=547-606 P positive regulation of DNA-binding transcription factor activity
A/C=547-606 P positive regulation of gene expression
A/C=547-606 P positive regulation of neuron differentiation
A/C=547-606 P positive regulation of transcription by RNA polymerase II
A/C=547-606 P positive regulation of transcription, DNA-templated
A/C=547-606 P protein stabilization
A/C=547-606 P regulation of G1/S transition of mitotic cell cycle
A/C=547-606 P regulation of transcription by RNA polymerase II
A/C=547-606 P regulation of transcription, DNA-templated
A/C=547-606 P response to drug
A/C=547-606 P response to lipopolysaccharide
A/C=547-606 P T cell differentiation in thymus
B/D=102-160 C cytoplasm
B/D=102-160 C nucleoplasm
B/D=102-160 C nucleus
B/D=102-160 C RNA polymerase II transcription regulator complex
B/D=102-160 F chromatin binding
B/D=102-160 F DNA binding
B/D=102-160 F DNA-binding transcription activator activity, RNA polymerase II-specific
B/D=102-160 F DNA-binding transcription factor activity
B/D=102-160 F DNA-binding transcription factor activity, RNA polymerase II-specific
B/D=102-160 F double-stranded DNA binding
B/D=102-160 F E-box binding
B/D=102-160 F protein heterodimerization activity
B/D=102-160 F RNA polymerase II activating transcription factor binding
B/D=102-160 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
B/D=102-160 F sequence-specific DNA binding
B/D=102-160 F sequence-specific double-stranded DNA binding
B/D=102-160 F transcription factor binding
B/D=102-160 P amacrine cell differentiation
B/D=102-160 P anterior/posterior pattern specification
B/D=102-160 P camera-type eye development
B/D=102-160 P cell fate commitment
B/D=102-160 P cellular response to glucose stimulus
B/D=102-160 P cerebellum development
B/D=102-160 P dentate gyrus development
B/D=102-160 P embryonic organ morphogenesis
B/D=102-160 P endocrine pancreas development
B/D=102-160 P enteroendocrine cell differentiation
B/D=102-160 P glucose homeostasis
B/D=102-160 P hindbrain development
B/D=102-160 P inner ear development
B/D=102-160 P insulin secretion
B/D=102-160 P negative regulation of receptor signaling pathway via JAK-STAT
B/D=102-160 P negative regulation of type B pancreatic cell apoptotic process
B/D=102-160 P neuron development
B/D=102-160 P nitric oxide mediated signal transduction
B/D=102-160 P nucleocytoplasmic transport
B/D=102-160 P pancreatic A cell fate commitment
B/D=102-160 P pancreatic PP cell fate commitment
B/D=102-160 P positive regulation of apoptotic process
B/D=102-160 P positive regulation of cell differentiation
B/D=102-160 P positive regulation of DNA-binding transcription factor activity
B/D=102-160 P positive regulation of neuron differentiation
B/D=102-160 P positive regulation of transcription by RNA polymerase II
B/D=102-160 P positive regulation of transcription regulatory region DNA binding
B/D=102-160 P positive regulation of transcription, DNA-templated
B/D=102-160 P regulation of cell cycle arrest
B/D=102-160 P regulation of intestinal epithelial structure maintenance
B/D=102-160 P regulation of neuron differentiation
B/D=102-160 P response to drug
B/D=102-160 P response to glucose
B/D=102-160 P signal transduction involved in regulation of gene expression
Sequences
Download file with secondary structure created by Stride  
2ql2.pdb1.pdb:   [ download sequences in FASTA format ]
E (dna): 
Click "SHOW" for view sequence
F (dna): 
Click "SHOW" for view sequence
A (protein): 
Click "SHOW" for view sequence
B (protein): 
Click "SHOW" for view sequence
2ql2.pdb2.pdb:   [ download sequences in FASTA format ]
G (dna): 
Click "SHOW" for view sequence
H (dna): 
Click "SHOW" for view sequence
C (protein): 
Click "SHOW" for view sequence
D (protein): 
Click "SHOW" for view sequence
2ql2.pdb3.pdb:   [ download sequences in FASTA format ]
E (dna): 
Click "SHOW" for view sequence
F (dna): 
Click "SHOW" for view sequence
G (dna): 
Click "SHOW" for view sequence
H (dna): 
Click "SHOW" for view sequence
A (protein): 
Click "SHOW" for view sequence
B (protein): 
Click "SHOW" for view sequence
C (protein): 
Click "SHOW" for view sequence
D (protein): 
Click "SHOW" for view sequence
© NPIDB team 2003 - 2021

text