General information
PDB ID 2WBS
Title CRYSTAL STRUCTURE OF THE ZINC FINGER DOMAIN OF KLF4 BOUND TO ITS TARGET DNA
PDB header TRANSCRIPTION/DNA
Date 2009-03-03
Experimental method X-RAY DIFFRACTION
Resolution (A) 1.7
Kind dna
Organism MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb2wbs.pdb A FG 0
Biounits:
2wbs.pdb1.pdb A FG 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
zf-H2C2_2 Domain Q60793_446-469 6.1e-08 0 CL0361 A 446 471 FG  H-Bb H-Mj L-Bb 
zf-H2C2_2 Domain Q60793_415-437 2.4e-06 0 CL0361 A 416 443 FG  L-Bb 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A=395-483 C chromatin
A=395-483 C cytoplasm
A=395-483 C nuclear chromatin
A=395-483 C nuclear euchromatin
A=395-483 C nucleoplasm
A=395-483 C nucleus
A=395-483 C transcription regulator complex
A=395-483 F beta-catenin binding
A=395-483 F cis-regulatory region sequence-specific DNA binding
A=395-483 F DNA binding
A=395-483 F DNA-binding transcription activator activity, RNA polymerase II-specific
A=395-483 F DNA-binding transcription factor activity
A=395-483 F DNA-binding transcription factor activity, RNA polymerase II-specific
A=395-483 F double-stranded DNA binding
A=395-483 F histone deacetylase binding
A=395-483 F metal ion binding
A=395-483 F phosphatidylinositol 3-kinase regulator activity
A=395-483 F promoter-specific chromatin binding
A=395-483 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A=395-483 F RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity
A=395-483 F RNA polymerase II transcription factor binding
A=395-483 F sequence-specific DNA binding
A=395-483 F sequence-specific double-stranded DNA binding
A=395-483 F transcription cofactor binding
A=395-483 F transcription factor binding
A=395-483 F transcription regulatory region sequence-specific DNA binding
A=395-483 P canonical Wnt signaling pathway
A=395-483 P cell differentiation
A=395-483 P cellular response to cycloheximide
A=395-483 P cellular response to growth factor stimulus
A=395-483 P cellular response to hydrogen peroxide
A=395-483 P cellular response to laminar fluid shear stress
A=395-483 P cellular response to leukemia inhibitory factor
A=395-483 P cellular response to peptide
A=395-483 P cellular response to retinoic acid
A=395-483 P epidermal cell differentiation
A=395-483 P epidermis morphogenesis
A=395-483 P fat cell differentiation
A=395-483 P negative regulation of angiogenesis
A=395-483 P negative regulation of cell migration
A=395-483 P negative regulation of cell migration involved in sprouting angiogenesis
A=395-483 P negative regulation of cell population proliferation
A=395-483 P negative regulation of chemokine (C-X-C motif) ligand 2 production
A=395-483 P negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A=395-483 P negative regulation of DNA-binding transcription factor activity
A=395-483 P negative regulation of ERK1 and ERK2 cascade
A=395-483 P negative regulation of G1/S transition of mitotic cell cycle
A=395-483 P negative regulation of gene expression
A=395-483 P negative regulation of heterotypic cell-cell adhesion
A=395-483 P negative regulation of interleukin-8 production
A=395-483 P negative regulation of leukocyte adhesion to arterial endothelial cell
A=395-483 P negative regulation of muscle hyperplasia
A=395-483 P negative regulation of NF-kappaB transcription factor activity
A=395-483 P negative regulation of phosphatidylinositol 3-kinase signaling
A=395-483 P negative regulation of protein kinase B signaling
A=395-483 P negative regulation of response to cytokine stimulus
A=395-483 P negative regulation of smooth muscle cell proliferation
A=395-483 P negative regulation of transcription by RNA polymerase II
A=395-483 P negative regulation of transcription, DNA-templated
A=395-483 P positive regulation of cellular protein metabolic process
A=395-483 P positive regulation of core promoter binding
A=395-483 P positive regulation of gene expression
A=395-483 P positive regulation of hemoglobin biosynthetic process
A=395-483 P positive regulation of nitric oxide biosynthetic process
A=395-483 P positive regulation of pri-miRNA transcription by RNA polymerase II
A=395-483 P positive regulation of protein metabolic process
A=395-483 P positive regulation of sprouting angiogenesis
A=395-483 P positive regulation of telomerase activity
A=395-483 P positive regulation of transcription by RNA polymerase II
A=395-483 P positive regulation of transcription, DNA-templated
A=395-483 P post-embryonic camera-type eye development
A=395-483 P post-embryonic hemopoiesis
A=395-483 P regulation of axon regeneration
A=395-483 P regulation of blastocyst development
A=395-483 P regulation of cell differentiation
A=395-483 P regulation of cell population proliferation
A=395-483 P regulation of transcription by RNA polymerase II
A=395-483 P response to organic substance
A=395-483 P response to retinoic acid
A=395-483 P stem cell population maintenance
A=395-483 P transcription, DNA-templated
Sequences
Download file with secondary structure created by Stride  
2wbs.pdb1.pdb:   [ download sequences in FASTA format ]
F (dna): 
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G (dna): 
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A (protein): 
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