General information
PDB ID 3P57
Title CRYSTAL STRUCTURE OF THE P300 TAZ2 DOMAIN BOUND TO MEF2 ON DNA
PDB header TRANSFERASE/TRANSCRIPTION ACTIVATOR/DNA
Date 2010-10-08
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.19
Kind dna
Organism HOMO SAPIENS, SYNTHETIC CONSTRUCT
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb3p57.pdb ABCDIJP EFGHKL 0
Biounits:
3p57.pdb1.pdb ABCDIJP EFGHKL 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
SRF-TF Domain Q02078_10-57 3.3e-25 1 No_clan A 10 57 EF  H-Bb H-Mj 
SRF-TF Domain Q02078_10-57 3.3e-25 1 No_clan B 10 57 F  H-Bb H-Mj 
SRF-TF Domain Q02078_10-57 3.3e-25 1 No_clan C 10 57 H  H-Bb 
SRF-TF Domain Q02078_10-57 3.3e-25 1 No_clan D 10 57 G  H-Bb 
SRF-TF Domain Q02078_10-57 3.3e-25 1 No_clan I 10 57 KL  H-Bb H-Mj 
SRF-TF Domain Q02078_10-57 3.3e-25 1 No_clan J 10 57 K  H-Bb H-Mj 
zf-TAZ Family Q09472_1735-1806 1.1e-11 1 No_clan P 13 84   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/B/C/D/I/J=2-91 C cytosol
A/B/C/D/I/J=2-91 C nuclear chromatin
A/B/C/D/I/J=2-91 C nucleoplasm
A/B/C/D/I/J=2-91 C nucleus
A/B/C/D/I/J=2-91 C transcription regulator complex
A/B/C/D/I/J=2-91 F activating transcription factor binding
A/B/C/D/I/J=2-91 F chromatin binding
A/B/C/D/I/J=2-91 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/B/C/D/I/J=2-91 F DNA-binding transcription factor activity
A/B/C/D/I/J=2-91 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/B/C/D/I/J=2-91 F histone acetyltransferase binding
A/B/C/D/I/J=2-91 F histone deacetylase binding
A/B/C/D/I/J=2-91 F protein heterodimerization activity
A/B/C/D/I/J=2-91 F protein kinase binding
A/B/C/D/I/J=2-91 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/B/C/D/I/J=2-91 F RNA polymerase II transcription factor binding
A/B/C/D/I/J=2-91 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
A/B/C/D/I/J=2-91 F sequence-specific DNA binding
A/B/C/D/I/J=2-91 F SMAD binding
A/B/C/D/I/J=2-91 F transcription factor binding
A/B/C/D/I/J=2-91 F transcription regulatory region sequence-specific DNA binding
A/B/C/D/I/J=2-91 P apoptotic process
A/B/C/D/I/J=2-91 P cardiac conduction
A/B/C/D/I/J=2-91 P cell differentiation
A/B/C/D/I/J=2-91 P cellular response to calcium ion
A/B/C/D/I/J=2-91 P dendrite morphogenesis
A/B/C/D/I/J=2-91 P ERK5 cascade
A/B/C/D/I/J=2-91 P heart development
A/B/C/D/I/J=2-91 P MAPK cascade
A/B/C/D/I/J=2-91 P mitochondrial genome maintenance
A/B/C/D/I/J=2-91 P mitochondrion distribution
A/B/C/D/I/J=2-91 P muscle organ development
A/B/C/D/I/J=2-91 P negative regulation of transcription by RNA polymerase II
A/B/C/D/I/J=2-91 P positive regulation of cardiac muscle hypertrophy
A/B/C/D/I/J=2-91 P positive regulation of glucose import
A/B/C/D/I/J=2-91 P positive regulation of muscle cell differentiation
A/B/C/D/I/J=2-91 P positive regulation of transcription by RNA polymerase II
A/B/C/D/I/J=2-91 P transcription, DNA-templated
A/B/C/D/I/J=2-91 P ventricular cardiac myofibril assembly
P=1726-1835 C chromosome
P=1726-1835 C cytosol
P=1726-1835 C histone acetyltransferase complex
P=1726-1835 C nucleoplasm
P=1726-1835 C nucleus
P=1726-1835 C protein-DNA complex
P=1726-1835 C transcription regulator complex
P=1726-1835 F acetyltransferase activity
P=1726-1835 F activating transcription factor binding
P=1726-1835 F androgen receptor binding
P=1726-1835 F beta-catenin binding
P=1726-1835 F chromatin binding
P=1726-1835 F chromatin DNA binding
P=1726-1835 F damaged DNA binding
P=1726-1835 F DNA binding
P=1726-1835 F histone acetyltransferase activity
P=1726-1835 F histone butyryltransferase activity
P=1726-1835 F histone crotonyltransferase activity
P=1726-1835 F lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
P=1726-1835 F NF-kappaB binding
P=1726-1835 F nuclear hormone receptor binding
P=1726-1835 F p53 binding
P=1726-1835 F peptide butyryltransferase activity
P=1726-1835 F peptide-lysine-N-acetyltransferase activity
P=1726-1835 F pre-mRNA intronic binding
P=1726-1835 F protein C-terminus binding
P=1726-1835 F protein propionyltransferase activity
P=1726-1835 F RNA polymerase II activating transcription factor binding
P=1726-1835 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
P=1726-1835 F RNA polymerase II transcription factor binding
P=1726-1835 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
P=1726-1835 F STAT family protein binding
P=1726-1835 F tau protein binding
P=1726-1835 F transcription coactivator activity
P=1726-1835 F transcription factor binding
P=1726-1835 F transferase activity, transferring acyl groups
P=1726-1835 F zinc ion binding
P=1726-1835 P animal organ morphogenesis
P=1726-1835 P apoptotic process
P=1726-1835 P B cell differentiation
P=1726-1835 P behavioral defense response
P=1726-1835 P beta-catenin-TCF complex assembly
P=1726-1835 P cellular response to UV
P=1726-1835 P circadian rhythm
P=1726-1835 P DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
P=1726-1835 P face morphogenesis
P=1726-1835 P fat cell differentiation
P=1726-1835 P heart development
P=1726-1835 P histone acetylation
P=1726-1835 P histone H2B acetylation
P=1726-1835 P histone H4 acetylation
P=1726-1835 P internal peptidyl-lysine acetylation
P=1726-1835 P internal protein amino acid acetylation
P=1726-1835 P intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
P=1726-1835 P learning or memory
P=1726-1835 P lung development
P=1726-1835 P macrophage derived foam cell differentiation
P=1726-1835 P megakaryocyte development
P=1726-1835 P multicellular organism growth
P=1726-1835 P N-terminal peptidyl-lysine acetylation
P=1726-1835 P negative regulation of gluconeogenesis
P=1726-1835 P negative regulation of protein-containing complex assembly
P=1726-1835 P negative regulation of transcription by RNA polymerase II
P=1726-1835 P nervous system development
P=1726-1835 P Notch signaling pathway
P=1726-1835 P peptidyl-lysine acetylation
P=1726-1835 P peptidyl-lysine butyrylation
P=1726-1835 P peptidyl-lysine crotonylation
P=1726-1835 P peptidyl-lysine propionylation
P=1726-1835 P platelet formation
P=1726-1835 P positive regulation by host of viral transcription
P=1726-1835 P positive regulation of DNA-binding transcription factor activity
P=1726-1835 P positive regulation of gene expression, epigenetic
P=1726-1835 P positive regulation of neuron projection development
P=1726-1835 P positive regulation of NIK/NF-kappaB signaling
P=1726-1835 P positive regulation of Notch signaling pathway
P=1726-1835 P positive regulation of protein binding
P=1726-1835 P positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
P=1726-1835 P positive regulation of transcription by RNA polymerase II
P=1726-1835 P positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
P=1726-1835 P positive regulation of transcription of Notch receptor target
P=1726-1835 P positive regulation of transcription, DNA-templated
P=1726-1835 P positive regulation of transforming growth factor beta receptor signaling pathway
P=1726-1835 P positive regulation of type I interferon production
P=1726-1835 P protein acetylation
P=1726-1835 P protein destabilization
P=1726-1835 P protein deubiquitination
P=1726-1835 P protein stabilization
P=1726-1835 P regulation of androgen receptor signaling pathway
P=1726-1835 P regulation of autophagy
P=1726-1835 P regulation of cell cycle
P=1726-1835 P regulation of cellular response to heat
P=1726-1835 P regulation of glycolytic process
P=1726-1835 P regulation of megakaryocyte differentiation
P=1726-1835 P regulation of mitochondrion organization
P=1726-1835 P regulation of signal transduction by p53 class mediator
P=1726-1835 P regulation of transcription from RNA polymerase II promoter in response to hypoxia
P=1726-1835 P regulation of transcription, DNA-templated
P=1726-1835 P regulation of tubulin deacetylation
P=1726-1835 P response to estrogen
P=1726-1835 P response to hypoxia
P=1726-1835 P skeletal muscle tissue development
P=1726-1835 P somitogenesis
P=1726-1835 P stimulatory C-type lectin receptor signaling pathway
P=1726-1835 P swimming
P=1726-1835 P thigmotaxis
P=1726-1835 P transcription-coupled nucleotide-excision repair
P=1726-1835 P viral process
Sequences
Download file with secondary structure created by Stride  
3p57.pdb1.pdb:   [ download sequences in FASTA format ]
E (dna): 
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F (dna): 
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G (dna): 
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H (dna): 
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K (dna): 
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L (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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D (protein): 
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I (protein): 
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J (protein): 
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P (protein): 
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