General information
PDB ID 3WTU
Title CRYSTAL STRUCTURE OF THE COMPLEX COMPRISED OF ETS1 (V170A), RUNX1, CBFBETA, AND THE TCRALPHA GENE ENHANCER DNA
PDB header TRANSCRIPTION/DNA
Date 2014-04-21
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.7
Kind dna
Organism MUS MUSCULUS, HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb3wtu.pdb ABCFGH DEIJ 0
Biounits:
3wtu.pdb1.pdb ABC DE 1
3wtu.pdb2.pdb FGH IJ 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Runt Domain Q03347_60-179 9.3e-70 1 CL0073 A 60 177 DE  S-Bb S-Mj L-Bb L-Mj L-Mn 
Ets Domain P14921_336-415 1.3e-35 1 CL0123 C 336 415 DE  H-Bb H-Mj S-Bb L-Bb 
Runt Domain Q03347_60-179 9.3e-70 1 CL0073 F 60 177 IJ  S-Bb S-Mj L-Bb L-Mj L-Mn 
Ets Domain P14921_336-415 7.6e-36 1 CL0123 H 336 415 IJ  H-Bb H-Mj L-Bb 
CBF_beta Family Q08024_2-140 9.4e-69 1 No_clan B 2 140   
CBF_beta Family Q08024_2-140 1.8e-68 1 No_clan G 2 139   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/F=60-263 C basement membrane
A/F=60-263 C core-binding factor complex
A/F=60-263 C intracellular membrane-bounded organelle
A/F=60-263 C nucleoplasm
A/F=60-263 C nucleus
A/F=60-263 C protein-containing complex
A/F=60-263 F ATP binding
A/F=60-263 F calcium ion binding
A/F=60-263 F DNA binding
A/F=60-263 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/F=60-263 F DNA-binding transcription factor activity
A/F=60-263 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/F=60-263 F promoter-specific chromatin binding
A/F=60-263 F protein heterodimerization activity
A/F=60-263 F protein homodimerization activity
A/F=60-263 F repressing transcription factor binding
A/F=60-263 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/F=60-263 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
A/F=60-263 F sequence-specific double-stranded DNA binding
A/F=60-263 F transcription factor binding
A/F=60-263 F transcription regulatory region sequence-specific DNA binding
A/F=60-263 P behavioral response to pain
A/F=60-263 P cellular response to transforming growth factor beta stimulus
A/F=60-263 P central nervous system development
A/F=60-263 P chondrocyte differentiation
A/F=60-263 P definitive hemopoiesis
A/F=60-263 P embryonic hemopoiesis
A/F=60-263 P hair follicle morphogenesis
A/F=60-263 P hemopoiesis
A/F=60-263 P in utero embryonic development
A/F=60-263 P liver development
A/F=60-263 P myeloid cell differentiation
A/F=60-263 P myeloid progenitor cell differentiation
A/F=60-263 P negative regulation of CD4-positive, alpha-beta T cell differentiation
A/F=60-263 P negative regulation of cell population proliferation
A/F=60-263 P negative regulation of granulocyte differentiation
A/F=60-263 P negative regulation of transcription by RNA polymerase II
A/F=60-263 P negative regulation of transcription, DNA-templated
A/F=60-263 P neuron development
A/F=60-263 P neuron differentiation
A/F=60-263 P neuron fate commitment
A/F=60-263 P ossification
A/F=60-263 P positive regulation of angiogenesis
A/F=60-263 P positive regulation of CD8-positive, alpha-beta T cell differentiation
A/F=60-263 P positive regulation of cell maturation
A/F=60-263 P positive regulation of granulocyte differentiation
A/F=60-263 P positive regulation of interferon-gamma production
A/F=60-263 P positive regulation of interleukin-2 production
A/F=60-263 P positive regulation of progesterone secretion
A/F=60-263 P positive regulation of transcription by RNA polymerase II
A/F=60-263 P positive regulation of transcription, DNA-templated
A/F=60-263 P regulation of cell differentiation
A/F=60-263 P regulation of hair follicle cell proliferation
A/F=60-263 P regulation of signal transduction
A/F=60-263 P regulation of T cell anergy
A/F=60-263 P regulation of transcription by RNA polymerase II
A/F=60-263 P regulation of transcription, DNA-templated
A/F=60-263 P response to retinoic acid
A/F=60-263 P skeletal system development
B/G=1-142 C core-binding factor complex
B/G=1-142 C nucleoplasm
B/G=1-142 C nucleus
B/G=1-142 C protein-containing complex
B/G=1-142 F DNA binding
B/G=1-142 F transcription coactivator activity
B/G=1-142 F transcription coregulator activity
B/G=1-142 P cell maturation
B/G=1-142 P definitive hemopoiesis
B/G=1-142 P lymphocyte differentiation
B/G=1-142 P myeloid cell differentiation
B/G=1-142 P negative regulation of CD4-positive, alpha-beta T cell differentiation
B/G=1-142 P negative regulation of transcription by RNA polymerase II
B/G=1-142 P ossification
B/G=1-142 P osteoblast differentiation
B/G=1-142 P positive regulation of CD8-positive, alpha-beta T cell differentiation
B/G=1-142 P positive regulation of transcription by RNA polymerase II
B/G=1-142 P protein polyubiquitination
B/G=1-142 P regulation of transcription by RNA polymerase II
C/H=276-441 C cytoplasm
C/H=276-441 C host cell nucleus
C/H=276-441 C nuclear chromatin
C/H=276-441 C nucleoplasm
C/H=276-441 C nucleus
C/H=276-441 C transcription regulator complex
C/H=276-441 F DNA binding
C/H=276-441 F DNA-binding transcription activator activity, RNA polymerase II-specific
C/H=276-441 F DNA-binding transcription factor activity
C/H=276-441 F DNA-binding transcription factor activity, RNA polymerase II-specific
C/H=276-441 F histone acetyltransferase binding
C/H=276-441 F identical protein binding
C/H=276-441 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
C/H=276-441 F transcription factor binding
C/H=276-441 P angiogenesis involved in wound healing
C/H=276-441 P cell differentiation
C/H=276-441 P cell motility
C/H=276-441 P cellular response to hydrogen peroxide
C/H=276-441 P estrous cycle
C/H=276-441 P female pregnancy
C/H=276-441 P hypothalamus development
C/H=276-441 P immune response
C/H=276-441 P negative regulation of cell cycle
C/H=276-441 P negative regulation of cell population proliferation
C/H=276-441 P negative regulation of inflammatory response
C/H=276-441 P pituitary gland development
C/H=276-441 P PML body organization
C/H=276-441 P positive regulation of angiogenesis
C/H=276-441 P positive regulation of blood vessel endothelial cell migration
C/H=276-441 P positive regulation of cell population proliferation
C/H=276-441 P positive regulation of cellular component movement
C/H=276-441 P positive regulation of endothelial cell migration
C/H=276-441 P positive regulation of erythrocyte differentiation
C/H=276-441 P positive regulation of gene expression
C/H=276-441 P positive regulation of inflammatory response
C/H=276-441 P positive regulation of leukocyte adhesion to vascular endothelial cell
C/H=276-441 P positive regulation of pri-miRNA transcription by RNA polymerase II
C/H=276-441 P positive regulation of transcription by RNA polymerase II
C/H=276-441 P positive regulation of transcription, DNA-templated
C/H=276-441 P regulation of angiogenesis
C/H=276-441 P regulation of apoptotic process
C/H=276-441 P regulation of extracellular matrix disassembly
C/H=276-441 P regulation of transcription by RNA polymerase II
C/H=276-441 P response to antibiotic
C/H=276-441 P response to estradiol
C/H=276-441 P response to hypoxia
C/H=276-441 P response to interleukin-1
C/H=276-441 P response to laminar fluid shear stress
C/H=276-441 P response to mechanical stimulus
C/H=276-441 P transcription by RNA polymerase II
Sequences
Download file with secondary structure created by Stride  
3wtu.pdb1.pdb:   [ download sequences in FASTA format ]
D (dna): 
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E (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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3wtu.pdb2.pdb:   [ download sequences in FASTA format ]
I (dna): 
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J (dna): 
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F (protein): 
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G (protein): 
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H (protein): 
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