General information
PDB ID 4BUL
Title NOVEL HYDROXYL TRICYCLICS (E.G. GSK966587) AS POTENT INHIBITORS OF BACTERIAL TYPE IIA TOPOISOMERASES
PDB header ISOMERASE
Date 2013-06-20
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.6
Kind dna
Organism STAPHYLOCOCCUS AUREUS, SYNTHETIC CONSTRUCT
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb4bul.pdb AC EFGH 0
Biounits:
4bul.pdb1.pdb AC EFGH 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
DNA_topoisoIV Family Q99XG5_33-474 3.2e-156 1 No_clan A 1032 1473 EFGH  H-Bb S-Bb S-Mj S-Mn L-Bb L-Mn 
DNA_gyraseB_C Family P66937_580-634 6.6e-27 1 No_clan A 544 634 FG  H-Bb 
Toprim Family P66937_430-542 8.6e-17 1 CL0413 A 430 542 EFGH  H-Bb L-Bb L-Mn 
DNA_topoisoIV Family Q99XG5_33-474 3.2e-156 1 No_clan C 1032 1473 EFGH  H-Bb H-Mj S-Bb S-Mj S-Mn L-Bb 
DNA_gyraseB_C Family P66937_580-634 6.6e-27 1 No_clan C 544 634 EH  H-Bb 
Toprim Family P66937_430-542 8.5e-17 1 CL0413 C 430 542 EFGH  H-Bb L-Bb L-Mn 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/C=2-491 C chromosome
A/C=2-491 C cytoplasm
A/C=2-491 F ATP binding
A/C=2-491 F DNA binding
A/C=2-491 F DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A/C=2-491 P DNA topological change
A/C=2-491 P DNA-dependent DNA replication
A/C=2-491 P response to antibiotic
A/C=410-543, A/C=580-644 C chromosome
A/C=410-543, A/C=580-644 C cytoplasm
A/C=410-543, A/C=580-644 F ATP binding
A/C=410-543, A/C=580-644 F DNA binding
A/C=410-543, A/C=580-644 F DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A/C=410-543, A/C=580-644 F metal ion binding
A/C=410-543, A/C=580-644 P DNA topological change
A/C=410-543, A/C=580-644 P DNA-dependent DNA replication
Sequences
Download file with secondary structure created by Stride  
4bul.pdb1.pdb:   [ download sequences in FASTA format ]
E (dna): 
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F (dna): 
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G (dna): 
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H (dna): 
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A (protein): 
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C (protein): 
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