General information
PDB ID 4FM9
Title HUMAN TOPOISOMERASE II ALPHA BOUND TO DNA
PDB header ISOMERASE/DNA
Date 2012-06-15
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.9
Kind dna
Organism HOMO SAPIENS, SYNTHETIC CONSTRUCT
Download
complex
View in
Jmol
Quick Links
PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb4fm9.pdb A CD 0
Biounits:
4fm9.pdb1.pdb A CD 2
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
DNA_topoisoIV Family P11388_713-1172 3.6e-135 1 No_clan A 713 1172 CD  H-Bb H-Mj S-Bb S-Mj S-Mn L-Bb 
TOPRIM_C Family P11388_573-711 8.9e-51 1 No_clan A 573 711 D  H-Bb 
Toprim Family P11388_456-572 1.3e-09 1 CL0413 A 456 572 CD  H-Bb S-Bb L-Bb L-Mn 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A=431-1193 C chromosome, centromeric region
A=431-1193 C condensed chromosome
A=431-1193 C cytoplasm
A=431-1193 C DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
A=431-1193 C nucleolus
A=431-1193 C nucleoplasm
A=431-1193 C nucleus
A=431-1193 C protein-containing complex
A=431-1193 C ribonucleoprotein complex
A=431-1193 C viral integration complex
A=431-1193 F ATP binding
A=431-1193 F chromatin binding
A=431-1193 F DNA binding
A=431-1193 F DNA binding, bending
A=431-1193 F DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A=431-1193 F DNA-dependent ATPase activity
A=431-1193 F drug binding
A=431-1193 F enzyme binding
A=431-1193 F histone deacetylase binding
A=431-1193 F magnesium ion binding
A=431-1193 F protein C-terminus binding
A=431-1193 F protein heterodimerization activity
A=431-1193 F protein homodimerization activity
A=431-1193 F protein kinase C binding
A=431-1193 F RNA binding
A=431-1193 F ubiquitin binding
A=431-1193 P apoptotic chromosome condensation
A=431-1193 P cellular response to DNA damage stimulus
A=431-1193 P chromosome segregation
A=431-1193 P DNA ligation
A=431-1193 P DNA topological change
A=431-1193 P embryonic cleavage
A=431-1193 P female meiotic nuclear division
A=431-1193 P hematopoietic progenitor cell differentiation
A=431-1193 P mitotic DNA integrity checkpoint
A=431-1193 P negative regulation of DNA duplex unwinding
A=431-1193 P positive regulation of apoptotic process
A=431-1193 P positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
A=431-1193 P positive regulation of transcription by RNA polymerase II
A=431-1193 P regulation of circadian rhythm
A=431-1193 P resolution of meiotic recombination intermediates
A=431-1193 P rhythmic process
A=431-1193 P sister chromatid segregation
Sequences
Download file with secondary structure created by Stride  
4fm9.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
Click "SHOW" for view sequence
D (dna): 
Click "SHOW" for view sequence
A (protein): 
Click "SHOW" for view sequence
© NPIDB team 2003 - 2021

text