General information
PDB ID 4H10
Title INTERMOLECULAR RECOGNITION REVEALED BY THE COMPLEX STRUCTURE OF HUMAN CLOCK-BMAL1 BASIC HELIX-LOOP-HELIX DOMAINS WITH E-BOX DNA
PDB header TRANSCRIPTION/DNA
Date 2012-09-10
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.4
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb4h10.pdb AB CD 0
Biounits:
4h10.pdb1.pdb AB CD 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
HLH Domain O00327_73-126 1.3e-18 1 No_clan A 73 126 CD  H-Bb H-Mj L-Bb 
HLH Domain O15516_35-85 1.8e-12 1 No_clan B 35 85 CD  H-Bb H-Mj L-Bb 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A=66-128 C chromatoid body
A=66-128 C intracellular membrane-bounded organelle
A=66-128 C nuclear chromatin
A=66-128 C nucleoplasm
A=66-128 C nucleus
A=66-128 C PML body
A=66-128 C transcription regulator complex
A=66-128 F aryl hydrocarbon receptor binding
A=66-128 F bHLH transcription factor binding
A=66-128 F DNA binding
A=66-128 F DNA-binding transcription activator activity, RNA polymerase II-specific
A=66-128 F DNA-binding transcription factor activity, RNA polymerase II-specific
A=66-128 F DNA-binding transcription factor binding
A=66-128 F E-box binding
A=66-128 F Hsp90 protein binding
A=66-128 F protein heterodimerization activity
A=66-128 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A=66-128 F sequence-specific DNA binding
A=66-128 F sequence-specific double-stranded DNA binding
A=66-128 F transcription regulatory region sequence-specific DNA binding
A=66-128 P circadian regulation of gene expression
A=66-128 P circadian rhythm
A=66-128 P maternal process involved in parturition
A=66-128 P negative regulation of cold-induced thermogenesis
A=66-128 P negative regulation of fat cell differentiation
A=66-128 P negative regulation of glucocorticoid receptor signaling pathway
A=66-128 P negative regulation of TOR signaling
A=66-128 P negative regulation of transcription, DNA-templated
A=66-128 P oxidative stress-induced premature senescence
A=66-128 P positive regulation of canonical Wnt signaling pathway
A=66-128 P positive regulation of circadian rhythm
A=66-128 P positive regulation of protein acetylation
A=66-128 P positive regulation of skeletal muscle cell differentiation
A=66-128 P positive regulation of transcription by RNA polymerase II
A=66-128 P positive regulation of transcription, DNA-templated
A=66-128 P proteasome-mediated ubiquitin-dependent protein catabolic process
A=66-128 P protein import into nucleus
A=66-128 P regulation of cell cycle
A=66-128 P regulation of cellular senescence
A=66-128 P regulation of hair cycle
A=66-128 P regulation of insulin secretion
A=66-128 P regulation of neurogenesis
A=66-128 P regulation of protein catabolic process
A=66-128 P regulation of transcription, DNA-templated
A=66-128 P regulation of type B pancreatic cell development
A=66-128 P response to redox state
A=66-128 P spermatogenesis
B=29-89 C chromatoid body
B=29-89 C chromosome
B=29-89 C cytosol
B=29-89 C intracellular membrane-bounded organelle
B=29-89 C nuclear chromatin
B=29-89 C nucleoplasm
B=29-89 C nucleus
B=29-89 C transcription regulator complex
B=29-89 F chromatin DNA binding
B=29-89 F DNA binding
B=29-89 F DNA-binding transcription activator activity, RNA polymerase II-specific
B=29-89 F DNA-binding transcription factor activity
B=29-89 F DNA-binding transcription factor activity, RNA polymerase II-specific
B=29-89 F E-box binding
B=29-89 F histone acetyltransferase activity
B=29-89 F protein dimerization activity
B=29-89 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
B=29-89 F sequence-specific DNA binding
B=29-89 F sequence-specific double-stranded DNA binding
B=29-89 P cellular response to ionizing radiation
B=29-89 P circadian regulation of gene expression
B=29-89 P circadian rhythm
B=29-89 P DNA damage checkpoint
B=29-89 P negative regulation of glucocorticoid receptor signaling pathway
B=29-89 P negative regulation of transcription, DNA-templated
B=29-89 P photoperiodism
B=29-89 P positive regulation of inflammatory response
B=29-89 P positive regulation of NF-kappaB transcription factor activity
B=29-89 P positive regulation of transcription by RNA polymerase II
B=29-89 P positive regulation of transcription, DNA-templated
B=29-89 P proteasome-mediated ubiquitin-dependent protein catabolic process
B=29-89 P protein acetylation
B=29-89 P regulation of circadian rhythm
B=29-89 P regulation of hair cycle
B=29-89 P regulation of insulin secretion
B=29-89 P regulation of transcription by RNA polymerase II
B=29-89 P regulation of transcription, DNA-templated
B=29-89 P regulation of type B pancreatic cell development
B=29-89 P response to redox state
B=29-89 P signal transduction
B=29-89 P spermatogenesis
Sequences
Download file with secondary structure created by Stride  
4h10.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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A (protein): 
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B (protein): 
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