General information
PDB ID 4IQR
Title MULTI-DOMAIN ORGANIZATION OF THE HNF4ALPHA NUCLEAR RECEPTOR COMPLEX ON DNA
PDB header TRANSCRIPTION/DNA
Date 2013-01-13
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.9
Kind dna
Organism HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb4iqr.pdb ABEFIJKL CDGH 0
Biounits:
4iqr.pdb1.pdb ABIJ CD 1
4iqr.pdb2.pdb EFKL GH 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Hormone_recep Domain P41235_172-361 5.3e-39 1 No_clan A 163 352   
zf-C4 Domain P41235_58-127 5.2e-30 1 CL0167 A 49 118 CD  H-Bb H-Mj S-Bb L-Bb 
Hormone_recep Domain P41235_172-361 6.9e-39 1 No_clan B 153 352   
zf-C4 Domain P41235_58-127 5.4e-30 1 CL0167 B 49 118 CD  H-Bb H-Mj L-Bb 
Hormone_recep Domain P41235_172-361 5.4e-39 1 No_clan E 163 352   
zf-C4 Domain P41235_58-127 5.3e-30 1 CL0167 E 49 118 GH  H-Bb H-Mj L-Bb 
Hormone_recep Domain P41235_172-361 5.9e-39 1 No_clan F 163 352   
zf-C4 Domain P41235_58-127 5.6e-30 1 CL0167 F 49 118 GH  H-Bb H-Mj L-Bb 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/B/E/F=55-377 C cytoplasm
A/B/E/F=55-377 C nuclear chromatin
A/B/E/F=55-377 C nucleoplasm
A/B/E/F=55-377 C nucleus
A/B/E/F=55-377 F chromatin binding
A/B/E/F=55-377 F DNA binding
A/B/E/F=55-377 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/B/E/F=55-377 F DNA-binding transcription factor activity
A/B/E/F=55-377 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/B/E/F=55-377 F fatty acid binding
A/B/E/F=55-377 F protein homodimerization activity
A/B/E/F=55-377 F RNA polymerase II activating transcription factor binding
A/B/E/F=55-377 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/B/E/F=55-377 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
A/B/E/F=55-377 F sequence-specific double-stranded DNA binding
A/B/E/F=55-377 F signaling receptor binding
A/B/E/F=55-377 F transcription regulatory region sequence-specific DNA binding
A/B/E/F=55-377 F zinc ion binding
A/B/E/F=55-377 P anatomical structure development
A/B/E/F=55-377 P blood coagulation
A/B/E/F=55-377 P cell differentiation
A/B/E/F=55-377 P cholesterol homeostasis
A/B/E/F=55-377 P glucose homeostasis
A/B/E/F=55-377 P hepatocyte differentiation
A/B/E/F=55-377 P lipid homeostasis
A/B/E/F=55-377 P lipid metabolic process
A/B/E/F=55-377 P negative regulation of cell growth
A/B/E/F=55-377 P negative regulation of cell population proliferation
A/B/E/F=55-377 P negative regulation of transcription, DNA-templated
A/B/E/F=55-377 P ornithine metabolic process
A/B/E/F=55-377 P phospholipid homeostasis
A/B/E/F=55-377 P positive regulation of transcription by RNA polymerase II
A/B/E/F=55-377 P positive regulation of transcription, DNA-templated
A/B/E/F=55-377 P regulation of circadian rhythm
A/B/E/F=55-377 P regulation of gastrulation
A/B/E/F=55-377 P regulation of growth hormone receptor signaling pathway
A/B/E/F=55-377 P regulation of insulin secretion
A/B/E/F=55-377 P regulation of lipid metabolic process
A/B/E/F=55-377 P regulation of transcription by RNA polymerase II
A/B/E/F=55-377 P response to glucose
A/B/E/F=55-377 P rhythmic process
A/B/E/F=55-377 P sex differentiation
A/B/E/F=55-377 P signal transduction involved in regulation of gene expression
A/B/E/F=55-377 P SMAD protein signal transduction
A/B/E/F=55-377 P transcription initiation from RNA polymerase II promoter
A/B/E/F=55-377 P triglyceride homeostasis
A/B/E/F=55-377 P type B pancreatic cell development
A/B/E/F=55-377 P xenobiotic metabolic process
I/J/K/L=685-697 C cytoplasm
I/J/K/L=685-697 C nuclear body
I/J/K/L=685-697 C nuclear chromatin
I/J/K/L=685-697 C nucleoplasm
I/J/K/L=685-697 C nucleus
I/J/K/L=685-697 C protein-containing complex
I/J/K/L=685-697 F aryl hydrocarbon receptor binding
I/J/K/L=685-697 F chromatin binding
I/J/K/L=685-697 F DNA-binding transcription factor activity, RNA polymerase II-specific
I/J/K/L=685-697 F nuclear hormone receptor binding
I/J/K/L=685-697 F nuclear receptor binding
I/J/K/L=685-697 F nuclear receptor transcription coactivator activity
I/J/K/L=685-697 F protein dimerization activity
I/J/K/L=685-697 F protein domain specific binding
I/J/K/L=685-697 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
I/J/K/L=685-697 F RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
I/J/K/L=685-697 F thyroid hormone receptor coactivator activity
I/J/K/L=685-697 F transcription coactivator activity
I/J/K/L=685-697 P bile acid and bile salt transport
I/J/K/L=685-697 P cellular response to hormone stimulus
I/J/K/L=685-697 P cellular response to Thyroglobulin triiodothyronine
I/J/K/L=685-697 P circadian regulation of gene expression
I/J/K/L=685-697 P locomotor rhythm
I/J/K/L=685-697 P negative regulation of transcription by RNA polymerase II
I/J/K/L=685-697 P positive regulation of transcription by RNA polymerase II
I/J/K/L=685-697 P regulation of glucose metabolic process
I/J/K/L=685-697 P regulation of lipid metabolic process
I/J/K/L=685-697 P regulation of transcription, DNA-templated
I/J/K/L=685-697 P response to progesterone
Sequences
Download file with secondary structure created by Stride  
4iqr.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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A (protein): 
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B (protein): 
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I (protein): 
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J (protein): 
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4iqr.pdb2.pdb:   [ download sequences in FASTA format ]
G (dna): 
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H (dna): 
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E (protein): 
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F (protein): 
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K (protein): 
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L (protein): 
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