General information
PDB ID 4L18
Title CRYSTAL STRUCTURE OF RUNX1 AND ETS1 BOUND TO TCR ALPHA PROMOTER (CRYSTAL FORM 3)
PDB header TRANSCRIPTION/DNA
Date 2013-06-02
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.3
Kind dna
Organism MUS MUSCULUS, HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb4l18.pdb ABEF CDGH 0
Biounits:
4l18.pdb1.pdb AB CD 1
4l18.pdb2.pdb EF GH 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Runt Domain Q03347_55-177 3.8e-74 1 CL0073 A 53 190 CD  S-Bb S-Mj L-Bb L-Mj L-Mn 
Ets Domain P14921_336-415 9.3e-36 1 CL0123 B 336 415 CD  H-Bb H-Mj L-Bb 
Runt Domain Q03347_55-177 2e-74 1 CL0073 E 52 191 GH  S-Bb S-Mj L-Bb L-Mj L-Mn 
Ets Domain P14921_336-415 9e-36 1 CL0123 F 336 415 GH  H-Bb H-Mj S-Bb L-Bb 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/E=48-214 C basement membrane
A/E=48-214 C core-binding factor complex
A/E=48-214 C intracellular membrane-bounded organelle
A/E=48-214 C nucleoplasm
A/E=48-214 C nucleus
A/E=48-214 C protein-containing complex
A/E=48-214 F ATP binding
A/E=48-214 F calcium ion binding
A/E=48-214 F DNA binding
A/E=48-214 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/E=48-214 F DNA-binding transcription factor activity
A/E=48-214 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/E=48-214 F promoter-specific chromatin binding
A/E=48-214 F protein heterodimerization activity
A/E=48-214 F protein homodimerization activity
A/E=48-214 F repressing transcription factor binding
A/E=48-214 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/E=48-214 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
A/E=48-214 F sequence-specific double-stranded DNA binding
A/E=48-214 F transcription factor binding
A/E=48-214 F transcription regulatory region sequence-specific DNA binding
A/E=48-214 P behavioral response to pain
A/E=48-214 P cellular response to transforming growth factor beta stimulus
A/E=48-214 P central nervous system development
A/E=48-214 P chondrocyte differentiation
A/E=48-214 P definitive hemopoiesis
A/E=48-214 P embryonic hemopoiesis
A/E=48-214 P hair follicle morphogenesis
A/E=48-214 P hemopoiesis
A/E=48-214 P in utero embryonic development
A/E=48-214 P liver development
A/E=48-214 P myeloid cell differentiation
A/E=48-214 P myeloid progenitor cell differentiation
A/E=48-214 P negative regulation of CD4-positive, alpha-beta T cell differentiation
A/E=48-214 P negative regulation of cell population proliferation
A/E=48-214 P negative regulation of granulocyte differentiation
A/E=48-214 P negative regulation of transcription by RNA polymerase II
A/E=48-214 P negative regulation of transcription, DNA-templated
A/E=48-214 P neuron development
A/E=48-214 P neuron differentiation
A/E=48-214 P neuron fate commitment
A/E=48-214 P ossification
A/E=48-214 P positive regulation of angiogenesis
A/E=48-214 P positive regulation of CD8-positive, alpha-beta T cell differentiation
A/E=48-214 P positive regulation of cell maturation
A/E=48-214 P positive regulation of granulocyte differentiation
A/E=48-214 P positive regulation of interferon-gamma production
A/E=48-214 P positive regulation of interleukin-2 production
A/E=48-214 P positive regulation of progesterone secretion
A/E=48-214 P positive regulation of transcription by RNA polymerase II
A/E=48-214 P positive regulation of transcription, DNA-templated
A/E=48-214 P regulation of cell differentiation
A/E=48-214 P regulation of hair follicle cell proliferation
A/E=48-214 P regulation of signal transduction
A/E=48-214 P regulation of T cell anergy
A/E=48-214 P regulation of transcription by RNA polymerase II
A/E=48-214 P regulation of transcription, DNA-templated
A/E=48-214 P response to retinoic acid
A/E=48-214 P skeletal system development
B/F=296-441 C cytoplasm
B/F=296-441 C host cell nucleus
B/F=296-441 C nuclear chromatin
B/F=296-441 C nucleoplasm
B/F=296-441 C nucleus
B/F=296-441 C transcription regulator complex
B/F=296-441 F DNA binding
B/F=296-441 F DNA-binding transcription activator activity, RNA polymerase II-specific
B/F=296-441 F DNA-binding transcription factor activity
B/F=296-441 F DNA-binding transcription factor activity, RNA polymerase II-specific
B/F=296-441 F histone acetyltransferase binding
B/F=296-441 F identical protein binding
B/F=296-441 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
B/F=296-441 F transcription factor binding
B/F=296-441 P angiogenesis involved in wound healing
B/F=296-441 P cell differentiation
B/F=296-441 P cell motility
B/F=296-441 P cellular response to hydrogen peroxide
B/F=296-441 P estrous cycle
B/F=296-441 P female pregnancy
B/F=296-441 P hypothalamus development
B/F=296-441 P immune response
B/F=296-441 P negative regulation of cell cycle
B/F=296-441 P negative regulation of cell population proliferation
B/F=296-441 P negative regulation of inflammatory response
B/F=296-441 P pituitary gland development
B/F=296-441 P PML body organization
B/F=296-441 P positive regulation of angiogenesis
B/F=296-441 P positive regulation of blood vessel endothelial cell migration
B/F=296-441 P positive regulation of cell population proliferation
B/F=296-441 P positive regulation of cellular component movement
B/F=296-441 P positive regulation of endothelial cell migration
B/F=296-441 P positive regulation of erythrocyte differentiation
B/F=296-441 P positive regulation of gene expression
B/F=296-441 P positive regulation of inflammatory response
B/F=296-441 P positive regulation of leukocyte adhesion to vascular endothelial cell
B/F=296-441 P positive regulation of pri-miRNA transcription by RNA polymerase II
B/F=296-441 P positive regulation of transcription by RNA polymerase II
B/F=296-441 P positive regulation of transcription, DNA-templated
B/F=296-441 P regulation of angiogenesis
B/F=296-441 P regulation of apoptotic process
B/F=296-441 P regulation of extracellular matrix disassembly
B/F=296-441 P regulation of transcription by RNA polymerase II
B/F=296-441 P response to antibiotic
B/F=296-441 P response to estradiol
B/F=296-441 P response to hypoxia
B/F=296-441 P response to interleukin-1
B/F=296-441 P response to laminar fluid shear stress
B/F=296-441 P response to mechanical stimulus
B/F=296-441 P transcription by RNA polymerase II
Sequences
Download file with secondary structure created by Stride  
4l18.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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A (protein): 
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B (protein): 
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4l18.pdb2.pdb:   [ download sequences in FASTA format ]
G (dna): 
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H (dna): 
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E (protein): 
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F (protein): 
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