General information
PDB ID 4NQA
Title CRYSTAL STRUCTURE OF LIGANDED HRXR-ALPHA/HLXR-BETA HETERODIMER ON DNA
PDB header TRANSCRIPTION REGULATOR/DNA
Date 2013-11-24
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.1
Kind dna
Organism HOMO SAPIENS, SYNTHETIC CONSTRUCT
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb4nqa.pdb ABCDHIJK EFLM 0
Biounits:
4nqa.pdb1.pdb ABCD EF 1
4nqa.pdb2.pdb HIJK LM 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Hormone_recep Domain P19793_257-442 1.8e-37 1 No_clan A 257 442   
zf-C4 Domain P19793_133-202 4e-32 1 CL0167 A 133 202 EF  H-Bb H-Mj L-Bb 
Hormone_recep Domain P55055_256-444 4.4e-27 1 No_clan B 257 445   
zf-C4 Domain P55055_85-156 1.1e-24 1 CL0167 B 85 156 EF  H-Bb H-Mj S-Bb S-Mj L-Bb 
SRC-1 Domain Q15596_687-698 0.00089 0 No_clan D 687 698   
Hormone_recep Domain P19793_263-442 8.3e-38 1 No_clan H 241 442   
zf-C4 Domain P19793_133-202 4.1e-32 1 CL0167 H 133 202 LM  H-Bb H-Mj L-Bb 
Hormone_recep Domain P55055_256-444 4.9e-27 1 No_clan I 257 445   
zf-C4 Domain P55055_85-156 1.1e-24 1 CL0167 I 85 156 LM  H-Bb H-Mj S-Bb S-Mj L-Bb 
SRC-1 Domain Q15596_687-698 0.00089 0 No_clan J 687 698   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/H=98-462 C mitochondrion
A/H=98-462 C nuclear chromatin
A/H=98-462 C nucleoplasm
A/H=98-462 C nucleus
A/H=98-462 C protein-containing complex
A/H=98-462 C receptor complex
A/H=98-462 C RNA polymerase II transcription regulator complex
A/H=98-462 F chromatin DNA binding
A/H=98-462 F DNA binding domain binding
A/H=98-462 F DNA-binding transcription factor activity
A/H=98-462 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/H=98-462 F double-stranded DNA binding
A/H=98-462 F enzyme binding
A/H=98-462 F identical protein binding
A/H=98-462 F LBD domain binding
A/H=98-462 F nuclear receptor activity
A/H=98-462 F nuclear receptor binding
A/H=98-462 F peptide binding
A/H=98-462 F retinoic acid binding
A/H=98-462 F retinoic acid-responsive element binding
A/H=98-462 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/H=98-462 F RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
A/H=98-462 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
A/H=98-462 F sequence-specific DNA binding
A/H=98-462 F sequence-specific double-stranded DNA binding
A/H=98-462 F steroid hormone receptor activity
A/H=98-462 F transcription regulatory region sequence-specific DNA binding
A/H=98-462 F vitamin D receptor binding
A/H=98-462 F zinc ion binding
A/H=98-462 P anatomical structure development
A/H=98-462 P bile acid and bile salt transport
A/H=98-462 P camera-type eye development
A/H=98-462 P cardiac muscle cell proliferation
A/H=98-462 P cell differentiation
A/H=98-462 P cholesterol metabolic process
A/H=98-462 P embryo implantation
A/H=98-462 P in utero embryonic development
A/H=98-462 P maternal placenta development
A/H=98-462 P modulation by virus of host process
A/H=98-462 P negative regulation of transcription by RNA polymerase II
A/H=98-462 P peroxisome proliferator activated receptor signaling pathway
A/H=98-462 P positive regulation of transcription by RNA polymerase II
A/H=98-462 P positive regulation of transcription, DNA-templated
A/H=98-462 P positive regulation of translational initiation by iron
A/H=98-462 P regulation of branching involved in prostate gland morphogenesis
A/H=98-462 P regulation of lipid metabolic process
A/H=98-462 P regulation of transcription by RNA polymerase II
A/H=98-462 P response to retinoic acid
A/H=98-462 P retinoic acid receptor signaling pathway
A/H=98-462 P secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
A/H=98-462 P transcription initiation from RNA polymerase II promoter
A/H=98-462 P ventricular cardiac muscle cell differentiation
A/H=98-462 P ventricular cardiac muscle tissue morphogenesis
B/I=72-460 C cytoplasm
B/I=72-460 C nuclear chromatin
B/I=72-460 C nucleoplasm
B/I=72-460 C nucleus
B/I=72-460 C RNA polymerase II transcription regulator complex
B/I=72-460 F apolipoprotein A-I receptor binding
B/I=72-460 F ATPase binding
B/I=72-460 F DNA binding
B/I=72-460 F DNA-binding transcription activator activity, RNA polymerase II-specific
B/I=72-460 F DNA-binding transcription factor activity, RNA polymerase II-specific
B/I=72-460 F nuclear receptor activity
B/I=72-460 F retinoid X receptor binding
B/I=72-460 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
B/I=72-460 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
B/I=72-460 F signaling receptor activity
B/I=72-460 F transcription factor binding
B/I=72-460 F zinc ion binding
B/I=72-460 P cell differentiation
B/I=72-460 P cholesterol homeostasis
B/I=72-460 P lipid homeostasis
B/I=72-460 P lipid metabolic process
B/I=72-460 P negative regulation of cholesterol storage
B/I=72-460 P negative regulation of cold-induced thermogenesis
B/I=72-460 P negative regulation of interferon-gamma-mediated signaling pathway
B/I=72-460 P negative regulation of lipid transport
B/I=72-460 P negative regulation of macrophage derived foam cell differentiation
B/I=72-460 P negative regulation of pinocytosis
B/I=72-460 P negative regulation of proteolysis
B/I=72-460 P negative regulation of response to endoplasmic reticulum stress
B/I=72-460 P negative regulation of transcription by RNA polymerase II
B/I=72-460 P negative regulation of transcription, DNA-templated
B/I=72-460 P phosphatidylcholine acyl-chain remodeling
B/I=72-460 P positive regulation of cellular protein metabolic process
B/I=72-460 P positive regulation of cholesterol efflux
B/I=72-460 P positive regulation of cholesterol transport
B/I=72-460 P positive regulation of fatty acid biosynthetic process
B/I=72-460 P positive regulation of high-density lipoprotein particle assembly
B/I=72-460 P positive regulation of lipid storage
B/I=72-460 P positive regulation of lipoprotein lipase activity
B/I=72-460 P positive regulation of pancreatic juice secretion
B/I=72-460 P positive regulation of secretion of lysosomal enzymes
B/I=72-460 P positive regulation of transcription by RNA polymerase II
B/I=72-460 P positive regulation of transcription, DNA-templated
B/I=72-460 P positive regulation of triglyceride biosynthetic process
B/I=72-460 P response to nutrient levels
B/I=72-460 P retinoic acid receptor signaling pathway
B/I=72-460 P transcription initiation from RNA polymerase II promoter
C/D/J/K=686-698 C cytoplasm
C/D/J/K=686-698 C nuclear body
C/D/J/K=686-698 C nuclear chromatin
C/D/J/K=686-698 C nucleoplasm
C/D/J/K=686-698 C nucleus
C/D/J/K=686-698 C protein-containing complex
C/D/J/K=686-698 F aryl hydrocarbon receptor binding
C/D/J/K=686-698 F chromatin binding
C/D/J/K=686-698 F DNA-binding transcription factor activity, RNA polymerase II-specific
C/D/J/K=686-698 F nuclear hormone receptor binding
C/D/J/K=686-698 F nuclear receptor binding
C/D/J/K=686-698 F nuclear receptor transcription coactivator activity
C/D/J/K=686-698 F protein dimerization activity
C/D/J/K=686-698 F protein domain specific binding
C/D/J/K=686-698 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
C/D/J/K=686-698 F RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
C/D/J/K=686-698 F thyroid hormone receptor coactivator activity
C/D/J/K=686-698 F transcription coactivator activity
C/D/J/K=686-698 P bile acid and bile salt transport
C/D/J/K=686-698 P cellular response to hormone stimulus
C/D/J/K=686-698 P cellular response to Thyroglobulin triiodothyronine
C/D/J/K=686-698 P circadian regulation of gene expression
C/D/J/K=686-698 P locomotor rhythm
C/D/J/K=686-698 P negative regulation of transcription by RNA polymerase II
C/D/J/K=686-698 P positive regulation of transcription by RNA polymerase II
C/D/J/K=686-698 P regulation of glucose metabolic process
C/D/J/K=686-698 P regulation of lipid metabolic process
C/D/J/K=686-698 P regulation of transcription, DNA-templated
C/D/J/K=686-698 P response to progesterone
Sequences
Download file with secondary structure created by Stride  
4nqa.pdb1.pdb:   [ download sequences in FASTA format ]
E (dna): 
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F (dna): 
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A (protein): 
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B (protein): 
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C (protein): 
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D (protein): 
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4nqa.pdb2.pdb:   [ download sequences in FASTA format ]
L (dna): 
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M (dna): 
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H (protein): 
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I (protein): 
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J (protein): 
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K (protein): 
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