General information
PDB ID 4R2C
Title EGR1/ZIF268 ZINC FINGERS IN COMPLEX WITH HYDROXYMETHYLATED DNA
PDB header DNA BINDING PROTEIN/DNA
Date 2014-08-11
Experimental method X-RAY DIFFRACTION
Resolution (A) 1.89
Kind dna
Organism HOMO SAPIENS, SYNTHETIC CONSTRUCT
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CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
 PDIdb 
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb4r2c.pdb A BC 0
Biounits:
4r2c.pdb1.pdb A BC 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
zf-H2C2_2 Domain P18146_383-407 6.3e-09 0 CL0361 A 382 407 B  H-Bb H-Mj 
zf-H2C2_2 Domain P18146_356-379 3e-08 0 CL0361 A 354 379 BC  H-Bb H-Mj S-Bb L-Bb 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A=335-423 C cytoplasm
A=335-423 C nuclear chromatin
A=335-423 C nucleoplasm
A=335-423 C nucleus
A=335-423 F DNA binding
A=335-423 F DNA-binding transcription activator activity, RNA polymerase II-specific
A=335-423 F DNA-binding transcription factor activity
A=335-423 F DNA-binding transcription factor activity, RNA polymerase II-specific
A=335-423 F double-stranded methylated DNA binding
A=335-423 F hemi-methylated DNA-binding
A=335-423 F histone acetyltransferase binding
A=335-423 F promoter-specific chromatin binding
A=335-423 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
A=335-423 F sequence-specific DNA binding
A=335-423 F sequence-specific double-stranded DNA binding
A=335-423 F transcription regulatory region sequence-specific DNA binding
A=335-423 F zinc ion binding
A=335-423 P BMP signaling pathway
A=335-423 P cellular response to gamma radiation
A=335-423 P cellular response to heparin
A=335-423 P cellular response to interleukin-8
A=335-423 P cellular response to mycophenolic acid
A=335-423 P circadian regulation of gene expression
A=335-423 P circadian temperature homeostasis
A=335-423 P estrous cycle
A=335-423 P glomerular mesangial cell proliferation
A=335-423 P interleukin-1-mediated signaling pathway
A=335-423 P locomotor rhythm
A=335-423 P negative regulation of canonical Wnt signaling pathway
A=335-423 P negative regulation of transcription by RNA polymerase II
A=335-423 P positive regulation of chemokine biosynthetic process
A=335-423 P positive regulation of gene expression
A=335-423 P positive regulation of glomerular metanephric mesangial cell proliferation
A=335-423 P positive regulation of hormone biosynthetic process
A=335-423 P positive regulation of interleukin-1 beta production
A=335-423 P positive regulation of neuron death
A=335-423 P positive regulation of pri-miRNA transcription by RNA polymerase II
A=335-423 P positive regulation of tau-protein kinase activity
A=335-423 P positive regulation of transcription by RNA polymerase II
A=335-423 P positive regulation of transcription, DNA-templated
A=335-423 P regulation of apoptotic process
A=335-423 P regulation of progesterone biosynthetic process
A=335-423 P regulation of protein sumoylation
A=335-423 P regulation of transcription from RNA polymerase II promoter in response to hypoxia
A=335-423 P response to glucose
A=335-423 P response to hypoxia
A=335-423 P response to insulin
A=335-423 P response to ischemia
A=335-423 P skeletal muscle cell differentiation
A=335-423 P T cell differentiation
A=335-423 P type I interferon signaling pathway
Sequences
Download file with secondary structure created by Stride  
4r2c.pdb1.pdb:   [ download sequences in FASTA format ]
B (dna): 
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C (dna): 
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A (protein): 
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