General information
PDB ID 4S0H
Title TBX5 DB, NKX2.5 HD, ANF DNA COMPLEX
PDB header TRANSCRIPTION/DNA
Date 2014-12-31
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.82
Kind dna
Organism HOMO SAPIENS, SYNTHETIC CONSTRUCT
Download
complex
View in
Jmol
Quick Links
PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb4s0h.pdb ABEF CDGH 0
Biounits:
4s0h.pdb1.pdb AB CD 1
4s0h.pdb2.pdb EF GH 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
T-box Domain Q99593_56-238 7.1e-78 1 CL0073 A 56 238 CD  H-Bb H-Mn S-Bb S-Mj L-Bb L-Mj 
Homeodomain Domain P52952_139-193 2.9e-20 1 CL0123 B 142 194 CD  H-Bb H-Mj L-Bb L-Mn 
T-box Domain Q99593_56-238 3e-78 1 CL0073 E 56 238 GH  H-Bb H-Mn S-Bb S-Mj L-Bb L-Mj 
Homeodomain Domain P52952_139-193 2.9e-20 1 CL0123 F 105 157 GH  H-Bb H-Mj L-Bb 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/E=53-238 C cytoplasm
A/E=53-238 C nuclear chromatin
A/E=53-238 C nucleoplasm
A/E=53-238 C nucleus
A/E=53-238 C protein-containing complex
A/E=53-238 C protein-DNA complex
A/E=53-238 F DNA binding
A/E=53-238 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/E=53-238 F DNA-binding transcription factor activity
A/E=53-238 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/E=53-238 F RNA polymerase II activating transcription factor binding
A/E=53-238 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/E=53-238 F RNA polymerase II transcription regulatory region sequence-specific DNA binding
A/E=53-238 F sequence-specific DNA binding
A/E=53-238 F transcription factor binding
A/E=53-238 P atrial septum morphogenesis
A/E=53-238 P atrioventricular valve morphogenesis
A/E=53-238 P bundle of His development
A/E=53-238 P cardiac left ventricle formation
A/E=53-238 P cardiac muscle cell differentiation
A/E=53-238 P cell fate specification
A/E=53-238 P cell migration involved in coronary vasculogenesis
A/E=53-238 P cell-cell signaling
A/E=53-238 P embryonic forelimb morphogenesis
A/E=53-238 P embryonic limb morphogenesis
A/E=53-238 P endocardial cushion development
A/E=53-238 P forelimb morphogenesis
A/E=53-238 P heart development
A/E=53-238 P lung development
A/E=53-238 P morphogenesis of an epithelium
A/E=53-238 P negative regulation of cardiac muscle cell proliferation
A/E=53-238 P negative regulation of cell migration
A/E=53-238 P negative regulation of cell population proliferation
A/E=53-238 P negative regulation of epithelial to mesenchymal transition
A/E=53-238 P negative regulation of transcription by RNA polymerase II
A/E=53-238 P pattern specification process
A/E=53-238 P pericardium development
A/E=53-238 P positive regulation of cardiac muscle cell proliferation
A/E=53-238 P positive regulation of cardioblast differentiation
A/E=53-238 P positive regulation of secondary heart field cardioblast proliferation
A/E=53-238 P positive regulation of transcription by RNA polymerase II
A/E=53-238 P positive regulation of transcription, DNA-templated
A/E=53-238 P transcription initiation from RNA polymerase II promoter
A/E=53-238 P ventricular septum development
B/F=142-192 C cytoplasm
B/F=142-192 C nuclear chromatin
B/F=142-192 C nucleus
B/F=142-192 C protein-containing complex
B/F=142-192 C protein-DNA complex
B/F=142-192 C RNA polymerase II transcription regulator complex
B/F=142-192 C transcription regulator complex
B/F=142-192 F chromatin binding
B/F=142-192 F DNA binding
B/F=142-192 F DNA-binding transcription activator activity, RNA polymerase II-specific
B/F=142-192 F DNA-binding transcription factor activity
B/F=142-192 F DNA-binding transcription factor activity, RNA polymerase II-specific
B/F=142-192 F protein homodimerization activity
B/F=142-192 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
B/F=142-192 F sequence-specific DNA binding
B/F=142-192 F sequence-specific double-stranded DNA binding
B/F=142-192 F transcription factor binding
B/F=142-192 F transcription regulatory region sequence-specific DNA binding
B/F=142-192 P adult heart development
B/F=142-192 P apoptotic process involved in heart morphogenesis
B/F=142-192 P atrial cardiac muscle cell development
B/F=142-192 P atrial septum morphogenesis
B/F=142-192 P atrioventricular node cell development
B/F=142-192 P atrioventricular node cell fate commitment
B/F=142-192 P bundle of His development
B/F=142-192 P cardiac conduction system development
B/F=142-192 P cardiac muscle cell differentiation
B/F=142-192 P cardiac muscle cell proliferation
B/F=142-192 P cardiac muscle contraction
B/F=142-192 P cardiac muscle tissue morphogenesis
B/F=142-192 P cardiac ventricle formation
B/F=142-192 P cell differentiation
B/F=142-192 P embryonic heart tube development
B/F=142-192 P embryonic heart tube left/right pattern formation
B/F=142-192 P heart looping
B/F=142-192 P heart morphogenesis
B/F=142-192 P heart trabecula formation
B/F=142-192 P hemopoiesis
B/F=142-192 P negative regulation of apoptotic process
B/F=142-192 P negative regulation of canonical Wnt signaling pathway
B/F=142-192 P negative regulation of cardiac muscle cell apoptotic process
B/F=142-192 P negative regulation of myotube differentiation
B/F=142-192 P negative regulation of transcription by RNA polymerase II
B/F=142-192 P negative regulation of transcription, DNA-templated
B/F=142-192 P outflow tract septum morphogenesis
B/F=142-192 P pharyngeal system development
B/F=142-192 P positive regulation of cardioblast differentiation
B/F=142-192 P positive regulation of cell population proliferation
B/F=142-192 P positive regulation of heart contraction
B/F=142-192 P positive regulation of neuron differentiation
B/F=142-192 P positive regulation of sodium ion transport
B/F=142-192 P positive regulation of transcription by RNA polymerase II
B/F=142-192 P positive regulation of transcription initiation from RNA polymerase II promoter
B/F=142-192 P positive regulation of transcription via serum response element binding
B/F=142-192 P positive regulation of transcription, DNA-templated
B/F=142-192 P proepicardium development
B/F=142-192 P pulmonary myocardium development
B/F=142-192 P Purkinje myocyte differentiation
B/F=142-192 P regulation of cardiac conduction
B/F=142-192 P regulation of cardiac muscle cell proliferation
B/F=142-192 P regulation of cardiac muscle contraction
B/F=142-192 P right ventricular cardiac muscle tissue morphogenesis
B/F=142-192 P sarcomere organization
B/F=142-192 P septum secundum development
B/F=142-192 P spleen development
B/F=142-192 P thyroid gland development
B/F=142-192 P vasculogenesis
B/F=142-192 P ventricular cardiac muscle cell development
B/F=142-192 P ventricular cardiac myofibril assembly
B/F=142-192 P ventricular septum morphogenesis
B/F=142-192 P ventricular trabecula myocardium morphogenesis
Sequences
Download file with secondary structure created by Stride  
4s0h.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
Click "SHOW" for view sequence
D (dna): 
Click "SHOW" for view sequence
A (protein): 
Click "SHOW" for view sequence
B (protein): 
Click "SHOW" for view sequence
4s0h.pdb2.pdb:   [ download sequences in FASTA format ]
G (dna): 
Click "SHOW" for view sequence
H (dna): 
Click "SHOW" for view sequence
E (protein): 
Click "SHOW" for view sequence
F (protein): 
Click "SHOW" for view sequence
© NPIDB team 2003 - 2021

text