General information
PDB ID 4WK8
Title FOXP3 FORMS A DOMAIN-SWAPPED DIMER TO BRIDGE DNA
PDB header TRANSCRIPTION/DNA
Date 2014-10-01
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.4
Kind dna
Organism SYNTHETIC CONSTRUCT, HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb4wk8.pdb FG AB 0
Biounits:
4wk8.pdb1.pdb FG AB 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Forkhead Domain Q9BZS1_336-417 1.2e-27 1 CL0123 F 337 416 AB  H-Bb H-Mj S-Bb 
Forkhead Domain Q9BZS1_336-417 1.2e-27 1 CL0123 G 337 416 BA  H-Bb 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
F/G=336-417 C cytoplasm
F/G=336-417 C nuclear chromatin
F/G=336-417 C nucleoplasm
F/G=336-417 C nucleus
F/G=336-417 C protein-containing complex
F/G=336-417 F DNA binding
F/G=336-417 F DNA-binding transcription factor activity
F/G=336-417 F DNA-binding transcription factor activity, RNA polymerase II-specific
F/G=336-417 F histone acetyltransferase binding
F/G=336-417 F histone deacetylase binding
F/G=336-417 F metal ion binding
F/G=336-417 F NF-kappaB binding
F/G=336-417 F NFAT protein binding
F/G=336-417 F protein homodimerization activity
F/G=336-417 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
F/G=336-417 F sequence-specific DNA binding
F/G=336-417 F sequence-specific double-stranded DNA binding
F/G=336-417 F transcription corepressor activity
F/G=336-417 P B cell homeostasis
F/G=336-417 P CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
F/G=336-417 P chromatin remodeling
F/G=336-417 P cytokine production
F/G=336-417 P myeloid cell homeostasis
F/G=336-417 P negative regulation of activated T cell proliferation
F/G=336-417 P negative regulation of cell population proliferation
F/G=336-417 P negative regulation of chronic inflammatory response
F/G=336-417 P negative regulation of CREB transcription factor activity
F/G=336-417 P negative regulation of cytokine biosynthetic process
F/G=336-417 P negative regulation of cytokine secretion
F/G=336-417 P negative regulation of DNA-binding transcription factor activity
F/G=336-417 P negative regulation of histone acetylation
F/G=336-417 P negative regulation of histone deacetylation
F/G=336-417 P negative regulation of immune response
F/G=336-417 P negative regulation of interferon-gamma production
F/G=336-417 P negative regulation of interleukin-10 production
F/G=336-417 P negative regulation of interleukin-17 production
F/G=336-417 P negative regulation of interleukin-2 production
F/G=336-417 P negative regulation of interleukin-4 production
F/G=336-417 P negative regulation of interleukin-5 production
F/G=336-417 P negative regulation of interleukin-6 production
F/G=336-417 P negative regulation of isotype switching to IgE isotypes
F/G=336-417 P negative regulation of NF-kappaB transcription factor activity
F/G=336-417 P negative regulation of T cell cytokine production
F/G=336-417 P negative regulation of T cell proliferation
F/G=336-417 P negative regulation of T-helper 17 cell differentiation
F/G=336-417 P negative regulation of transcription by RNA polymerase II
F/G=336-417 P negative regulation of transcription, DNA-templated
F/G=336-417 P negative regulation of tumor necrosis factor production
F/G=336-417 P positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
F/G=336-417 P positive regulation of histone acetylation
F/G=336-417 P positive regulation of immature T cell proliferation in thymus
F/G=336-417 P positive regulation of interleukin-4 production
F/G=336-417 P positive regulation of peripheral T cell tolerance induction
F/G=336-417 P positive regulation of T cell anergy
F/G=336-417 P positive regulation of transcription by RNA polymerase II
F/G=336-417 P positive regulation of transcription, DNA-templated
F/G=336-417 P positive regulation of transforming growth factor beta1 production
F/G=336-417 P regulation of isotype switching to IgG isotypes
F/G=336-417 P regulation of regulatory T cell differentiation
F/G=336-417 P regulation of T cell anergy
F/G=336-417 P regulation of transcription, DNA-templated
F/G=336-417 P regulation of Wnt signaling pathway
F/G=336-417 P response to virus
F/G=336-417 P T cell activation
F/G=336-417 P T cell homeostasis
F/G=336-417 P T cell mediated immunity
F/G=336-417 P T cell receptor signaling pathway
F/G=336-417 P tolerance induction to self antigen
Sequences
Download file with secondary structure created by Stride  
4wk8.pdb1.pdb:   [ download sequences in FASTA format ]
A (dna): 
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B (dna): 
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F (protein): 
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G (protein): 
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