General information
PDB ID 4XRS
Title HETERODIMERIC COMPLEX OF TRANSCRIPTION FACTORS MEIS1 AND DLX3 ON SPECIFIC DNA
PDB header TRANSCRIPTION
Date 2015-01-21
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.5
Kind dna
Organism SYNTHETIC CONSTRUCT, HOMO SAPIENS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb4xrs.pdb ABGI MDEL 0
Biounits:
4xrs.pdb1.pdb AG ML 1
4xrs.pdb2.pdb BI DE 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Homeodomain Domain O60479_131-186 3.7e-22 1 CL0123 G 131 186 LM   
Homeodomain Domain O60479_131-186 3.7e-22 1 CL0123 I 131 186 DE   
Homeobox_KN Family O00470_290-329 8.1e-22 1 CL0123 A 290 329 LM   
Homeobox_KN Family O00470_290-329 9e-22 1 CL0123 B 290 329 DE   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/B=279-336 C nuclear chromatin
A/B=279-336 C transcription regulator complex
A/B=279-336 F chromatin binding
A/B=279-336 F DNA binding
A/B=279-336 F DNA-binding transcription activator activity, RNA polymerase II-specific
A/B=279-336 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/B=279-336 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A/B=279-336 P angiogenesis
A/B=279-336 P animal organ morphogenesis
A/B=279-336 P brain development
A/B=279-336 P definitive hemopoiesis
A/B=279-336 P embryonic pattern specification
A/B=279-336 P eye development
A/B=279-336 P hemopoiesis
A/B=279-336 P lens morphogenesis in camera-type eye
A/B=279-336 P locomotory behavior
A/B=279-336 P megakaryocyte development
A/B=279-336 P negative regulation of cardiac muscle cell proliferation
A/B=279-336 P negative regulation of myeloid cell differentiation
A/B=279-336 P negative regulation of neuron differentiation
A/B=279-336 P positive regulation of cell population proliferation
A/B=279-336 P positive regulation of transcription by RNA polymerase II
G/I=131-186 C nuclear chromatin
G/I=131-186 C nucleus
G/I=131-186 F chromatin binding
G/I=131-186 F DNA binding
G/I=131-186 F DNA-binding transcription activator activity, RNA polymerase II-specific
G/I=131-186 F DNA-binding transcription factor activity
G/I=131-186 F DNA-binding transcription factor activity, RNA polymerase II-specific
G/I=131-186 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
G/I=131-186 F sequence-specific DNA binding
G/I=131-186 F sequence-specific double-stranded DNA binding
G/I=131-186 P blood vessel development
G/I=131-186 P cell differentiation
G/I=131-186 P epithelial cell differentiation
G/I=131-186 P odontoblast differentiation
G/I=131-186 P odontogenesis of dentin-containing tooth
G/I=131-186 P placenta development
G/I=131-186 P positive regulation of transcription by RNA polymerase II
G/I=131-186 P regulation of transcription by RNA polymerase II
Sequences
Download file with secondary structure created by Stride  
4xrs.pdb1.pdb:   [ download sequences in FASTA format ]
L (dna): 
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M (dna): 
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A (protein): 
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G (protein): 
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4xrs.pdb2.pdb:   [ download sequences in FASTA format ]
D (dna): 
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E (dna): 
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B (protein): 
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I (protein): 
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