General information
PDB ID 4ZPK
Title CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2A:ARNT COMPLEX WITH HRE DNA
PDB header PROTEIN TRANSPORT/TRANSCRIPTION/DNA
Date 2015-05-08
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.6
Kind dna
Organism MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb4zpk.pdb AB CD 0
Biounits:
4zpk.pdb1.pdb AB CD 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
PAS_11 Domain P53762_361-464 1.1e-20 1 CL0183 A 345 464   
HLH Domain P53762_90-142 8.5e-15 1 No_clan A 90 157 CD  H-Bb H-Mj L-Bb 
PAS Domain P53762_163-270 2.8e-11 1 CL0183 A 163 342   
PAS_3 Domain P97481_254-341 4.1e-20 1 CL0183 B 254 341   
PAS Domain P97481_85-184 2.4e-05 1 CL0183 B 85 201 C   
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A=82-464 C cytoplasm
A=82-464 C nuclear body
A=82-464 C nucleoplasm
A=82-464 C nucleus
A=82-464 C RNA polymerase II transcription regulator complex
A=82-464 C transcription regulator complex
A=82-464 F aryl hydrocarbon receptor binding
A=82-464 F cis-regulatory region sequence-specific DNA binding
A=82-464 F DNA-binding transcription factor activity
A=82-464 F nuclear receptor activity
A=82-464 F protein heterodimerization activity
A=82-464 F protein homodimerization activity
A=82-464 F protein-containing complex binding
A=82-464 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A=82-464 F sequence-specific DNA binding
A=82-464 F sequence-specific double-stranded DNA binding
A=82-464 F transcription factor binding
A=82-464 P cell differentiation
A=82-464 P embryonic placenta development
A=82-464 P positive regulation of hormone biosynthetic process
A=82-464 P positive regulation of protein sumoylation
A=82-464 P positive regulation of transcription by RNA polymerase II
A=82-464 P positive regulation of transcription, DNA-templated
A=82-464 P positive regulation of vascular endothelial growth factor production
A=82-464 P regulation of transcription from RNA polymerase II promoter in response to oxidative stress
A=82-464 P response to hypoxia
A=82-464 P response to toxic substance
B=3-361 C cytoplasm
B=3-361 C nuclear speck
B=3-361 C nucleus
B=3-361 C transcription regulator complex
B=3-361 F cis-regulatory region sequence-specific DNA binding
B=3-361 F cobalt ion binding
B=3-361 F DNA binding
B=3-361 F DNA-binding transcription activator activity, RNA polymerase II-specific
B=3-361 F DNA-binding transcription factor activity
B=3-361 F DNA-binding transcription factor activity, RNA polymerase II-specific
B=3-361 F histone acetyltransferase binding
B=3-361 F protein heterodimerization activity
B=3-361 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
B=3-361 F sequence-specific DNA binding
B=3-361 F transcription factor binding
B=3-361 P angiogenesis
B=3-361 P blood vessel remodeling
B=3-361 P cell differentiation
B=3-361 P cell maturation
B=3-361 P cellular response to hypoxia
B=3-361 P embryonic placenta development
B=3-361 P erythrocyte differentiation
B=3-361 P hemopoiesis
B=3-361 P iron ion homeostasis
B=3-361 P lung development
B=3-361 P mitochondrion organization
B=3-361 P myoblast fate commitment
B=3-361 P negative regulation of transcription by RNA polymerase II
B=3-361 P norepinephrine biosynthetic process
B=3-361 P norepinephrine metabolic process
B=3-361 P positive regulation of cold-induced thermogenesis
B=3-361 P positive regulation of dopamine biosynthetic process
B=3-361 P positive regulation of transcription by RNA polymerase II
B=3-361 P regulation of heart rate
B=3-361 P regulation of transcription by RNA polymerase II
B=3-361 P regulation of transcription from RNA polymerase II promoter in response to oxidative stress
B=3-361 P response to hypoxia
B=3-361 P response to oxidative stress
B=3-361 P surfactant homeostasis
B=3-361 P visual perception
Sequences
Download file with secondary structure created by Stride  
4zpk.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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A (protein): 
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B (protein): 
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