General information
PDB ID 5EGO
Title HOXB13-MEIS1 HETERODIMER BOUND TO METHYLATED DNA
PDB header TRANSCRIPTION
Date 2015-10-27
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.54
Kind dna
Organism HOMO SAPIENS, SYNTHETIC CONSTRUCT
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb5ego.pdb AB DE 0
Biounits:
5ego.pdb1.pdb AB DE 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
Homeodomain Domain Q92826_217-273 4.4e-19 1 CL0123 B 217 273 DE  H-Bb H-Mj 
Homeobox_KN Family O00470_290-329 8.5e-22 1 CL0123 A 290 329 DE  H-Bb H-Mj 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A=279-333 C nuclear chromatin
A=279-333 C transcription regulator complex
A=279-333 F chromatin binding
A=279-333 F DNA binding
A=279-333 F DNA-binding transcription activator activity, RNA polymerase II-specific
A=279-333 F DNA-binding transcription factor activity, RNA polymerase II-specific
A=279-333 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
A=279-333 P angiogenesis
A=279-333 P animal organ morphogenesis
A=279-333 P brain development
A=279-333 P definitive hemopoiesis
A=279-333 P embryonic pattern specification
A=279-333 P eye development
A=279-333 P hemopoiesis
A=279-333 P lens morphogenesis in camera-type eye
A=279-333 P locomotory behavior
A=279-333 P megakaryocyte development
A=279-333 P negative regulation of cardiac muscle cell proliferation
A=279-333 P negative regulation of myeloid cell differentiation
A=279-333 P negative regulation of neuron differentiation
A=279-333 P positive regulation of cell population proliferation
A=279-333 P positive regulation of transcription by RNA polymerase II
B=217-277 C nuclear chromatin
B=217-277 C nucleoplasm
B=217-277 C transcription regulator complex
B=217-277 F DNA-binding transcription factor activity, RNA polymerase II-specific
B=217-277 F DNA-binding transcription repressor activity, RNA polymerase II-specific
B=217-277 F methyl-CpG binding
B=217-277 F sequence-specific DNA binding
B=217-277 F sequence-specific double-stranded DNA binding
B=217-277 P angiogenesis
B=217-277 P epidermis development
B=217-277 P epithelial cell maturation involved in prostate gland development
B=217-277 P negative regulation of transcription by RNA polymerase II
B=217-277 P prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
B=217-277 P regulation of growth
B=217-277 P response to testosterone
B=217-277 P response to wounding
Sequences
Download file with secondary structure created by Stride  
5ego.pdb1.pdb:   [ download sequences in FASTA format ]
D (dna): 
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E (dna): 
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A (protein): 
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B (protein): 
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