General information
PDB ID 5GWI
Title STRUCTURE OF A HUMAN TOPOISOMERASE IIBETA FRAGMENT IN COMPLEX WITH DNA AND E7873R
PDB header ISOMERASE/DNA/ISOMERASE INHIBITOR
Date 2016-09-12
Experimental method X-RAY DIFFRACTION
Resolution (A) 2.74
Kind dna
Organism HOMO SAPIENS, SYNTHETIC CONSTRUCT
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb5gwi.pdb AB CDEF 0
Biounits:
5gwi.pdb1.pdb AB CDEF 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
DNA_topoisoIV Family Q02880_734-1190 1.3e-134 1 No_clan A 729 1185 CFD  H-Bb H-Mj S-Bb S-Mj S-Mn L-Bb 
TOPRIM_C Family Q02880_594-732 7.9e-24 1 No_clan A 581 727 F  H-Bb 
Toprim Family Q02880_477-592 9.2e-10 1 CL0413 A 472 588 CF  H-Bb S-Bb L-Bb L-Mn 
DNA_topoisoIV Family Q02880_734-1190 8.8e-135 1 No_clan B 729 1185 DEF  H-Bb H-Mj S-Bb S-Mj S-Mn L-Bb 
TOPRIM_C Family Q02880_594-732 3e-24 1 No_clan B 589 727 D  H-Bb 
Toprim Family Q02880_477-592 9.4e-10 1 CL0413 B 472 587 DE  H-Bb S-Bb L-Bb L-Mn 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/B=450-1206 C cytosol
A/B=450-1206 C nucleoplasm
A/B=450-1206 C nucleus
A/B=450-1206 C ribonucleoprotein complex
A/B=450-1206 C viral integration complex
A/B=450-1206 F ATP binding
A/B=450-1206 F chromatin binding
A/B=450-1206 F DNA binding
A/B=450-1206 F DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A/B=450-1206 F enzyme binding
A/B=450-1206 F histone deacetylase binding
A/B=450-1206 F metal ion binding
A/B=450-1206 F protein C-terminus binding
A/B=450-1206 F protein heterodimerization activity
A/B=450-1206 F protein kinase C binding
A/B=450-1206 P axonogenesis
A/B=450-1206 P DNA topological change
A/B=450-1206 P forebrain development
A/B=450-1206 P mitotic DNA integrity checkpoint
A/B=450-1206 P neuron migration
A/B=450-1206 P positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
A/B=450-1206 P resolution of meiotic recombination intermediates
A/B=450-1206 P sister chromatid segregation
Sequences
Download file with secondary structure created by Stride  
5gwi.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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E (dna): 
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F (dna): 
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A (protein): 
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B (protein): 
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