General information
PDB ID 5GWK
Title HUMAN TOPOISOMERASE IIALPHA IN COMPLEX WITH DNA AND ETOPOSIDE
PDB header ISOMERASE/DNA/ISOMERASE INHIBITOR
Date 2016-09-12
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.15
Kind dna
Organism HOMO SAPIENS, SYNTHETIC CONSTRUCT
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb5gwk.pdb AB CDEF 0
Biounits:
5gwk.pdb1.pdb AB CDEF 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
DNA_topoisoIV Family P11388_713-1172 5.9e-135 1 No_clan A 713 1172 CFD  H-Bb S-Bb S-Mj S-Mn L-Bb 
TOPRIM_C Family P11388_573-711 8.9e-51 1 No_clan A 573 711 F  H-Bb 
Toprim Family P11388_456-572 1.3e-09 1 CL0413 A 456 572 CF  H-Bb S-Bb L-Bb L-Mn 
DNA_topoisoIV Family P11388_713-1172 5.9e-135 1 No_clan B 713 1172 DEF  H-Bb S-Bb S-Mj S-Mn L-Bb 
TOPRIM_C Family P11388_573-711 8.9e-51 1 No_clan B 573 711 D  H-Bb L-Bb 
Toprim Family P11388_456-572 1.3e-09 1 CL0413 B 456 572 DE  H-Bb S-Bb L-Bb L-Mn 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/B=429-1188 C chromosome, centromeric region
A/B=429-1188 C condensed chromosome
A/B=429-1188 C cytoplasm
A/B=429-1188 C DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
A/B=429-1188 C nucleolus
A/B=429-1188 C nucleoplasm
A/B=429-1188 C nucleus
A/B=429-1188 C protein-containing complex
A/B=429-1188 C ribonucleoprotein complex
A/B=429-1188 C viral integration complex
A/B=429-1188 F ATP binding
A/B=429-1188 F chromatin binding
A/B=429-1188 F DNA binding
A/B=429-1188 F DNA binding, bending
A/B=429-1188 F DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A/B=429-1188 F DNA-dependent ATPase activity
A/B=429-1188 F drug binding
A/B=429-1188 F enzyme binding
A/B=429-1188 F histone deacetylase binding
A/B=429-1188 F magnesium ion binding
A/B=429-1188 F protein C-terminus binding
A/B=429-1188 F protein heterodimerization activity
A/B=429-1188 F protein homodimerization activity
A/B=429-1188 F protein kinase C binding
A/B=429-1188 F RNA binding
A/B=429-1188 F ubiquitin binding
A/B=429-1188 P apoptotic chromosome condensation
A/B=429-1188 P cellular response to DNA damage stimulus
A/B=429-1188 P chromosome segregation
A/B=429-1188 P DNA ligation
A/B=429-1188 P DNA topological change
A/B=429-1188 P embryonic cleavage
A/B=429-1188 P female meiotic nuclear division
A/B=429-1188 P hematopoietic progenitor cell differentiation
A/B=429-1188 P mitotic DNA integrity checkpoint
A/B=429-1188 P negative regulation of DNA duplex unwinding
A/B=429-1188 P positive regulation of apoptotic process
A/B=429-1188 P positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
A/B=429-1188 P positive regulation of transcription by RNA polymerase II
A/B=429-1188 P regulation of circadian rhythm
A/B=429-1188 P resolution of meiotic recombination intermediates
A/B=429-1188 P rhythmic process
A/B=429-1188 P sister chromatid segregation
Sequences
Download file with secondary structure created by Stride  
5gwk.pdb1.pdb:   [ download sequences in FASTA format ]
C (dna): 
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D (dna): 
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E (dna): 
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F (dna): 
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A (protein): 
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B (protein): 
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