General information
PDB ID 5NJ8
Title STRUCTURAL BASIS FOR ARYL HYDROCARBON RECEPTOR MEDIATED GENE ACTIVATION
PDB header TRANSCRIPTION
Date 2017-03-28
Experimental method X-RAY DIFFRACTION
Resolution (A) 3.3
Kind dna
Organism HOMO SAPIENS, MUS MUSCULUS
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PDB PDBe MMDB Jena OCA
CATH PDBsum HSSP PDBePISA UniProt
ProteopediA BIPA
Composition of PDB entry and biounits
File: Protein chains: DNA chains: RNA chains: No. of models: Action:
PDB entry:
pdb5nj8.pdb ABCD EFGH 0
Biounits:
5nj8.pdb1.pdb AB EF 1
5nj8.pdb2.pdb CD GH 1
Pfam domains
Name: Type: Domain: E-value: Significance: Clan: Prot. chain: Start res.: End res.: Nuc. chains: Int. mode: Action:
PAS Domain P35869_113-227 2.1e-12 1 CL0183 A 113 213   
HLH Domain P35869_35-80 1e-06 1 No_clan A 36 80 EF  H-Bb H-Mj L-Bb 
HLH Domain P27540_90-143 1.1e-11 1 No_clan B 90 143 EF  H-Bb H-Mj 
PAS Domain P27540_163-269 1.1e-10 1 CL0183 B 163 312   
PAS Domain P35869_113-227 1.2e-11 1 CL0183 C 113 227   
HLH Domain P35869_35-80 1e-06 1 No_clan C 36 80 GH  H-Bb H-Mj 
HLH Domain P27540_90-143 2.5e-15 1 No_clan D 90 143 GH  H-Bb H-Mj 
SCOP domains
No SCOP domains
GO terms
Protein chains: GO type: GO description:
A/C=23-273 C cytoplasm
A/C=23-273 C cytosol
A/C=23-273 C cytosolic aryl hydrocarbon receptor complex
A/C=23-273 C nuclear chromatin
A/C=23-273 C nucleoplasm
A/C=23-273 C nucleus
A/C=23-273 C protein-containing complex
A/C=23-273 C transcription regulator complex
A/C=23-273 F cis-regulatory region sequence-specific DNA binding
A/C=23-273 F DNA binding
A/C=23-273 F DNA-binding transcription factor activity
A/C=23-273 F DNA-binding transcription factor activity, RNA polymerase II-specific
A/C=23-273 F E-box binding
A/C=23-273 F Hsp90 protein binding
A/C=23-273 F nuclear receptor activity
A/C=23-273 F protein heterodimerization activity
A/C=23-273 F protein homodimerization activity
A/C=23-273 F sequence-specific double-stranded DNA binding
A/C=23-273 F TBP-class protein binding
A/C=23-273 F TFIID-class transcription factor complex binding
A/C=23-273 F transcription coactivator binding
A/C=23-273 F transcription factor binding
A/C=23-273 F transcription regulatory region sequence-specific DNA binding
A/C=23-273 P apoptotic process
A/C=23-273 P blood vessel development
A/C=23-273 P cAMP-mediated signaling
A/C=23-273 P cell cycle
A/C=23-273 P cellular response to 2,3,7,8-tetrachlorodibenzodioxine
A/C=23-273 P cellular response to cAMP
A/C=23-273 P cellular response to forskolin
A/C=23-273 P circadian regulation of gene expression
A/C=23-273 P negative regulation of transcription by RNA polymerase II
A/C=23-273 P negative regulation of transcription, DNA-templated
A/C=23-273 P positive regulation of transcription by RNA polymerase II
A/C=23-273 P positive regulation of transcription, DNA-templated
A/C=23-273 P regulation of B cell proliferation
A/C=23-273 P regulation of gene expression
A/C=23-273 P regulation of transcription by RNA polymerase II
A/C=23-273 P regulation of transcription, DNA-templated
A/C=23-273 P response to toxic substance
A/C=23-273 P response to xenobiotic stimulus
A/C=23-273 P xenobiotic metabolic process
B/D=84-345 C cytoplasm
B/D=84-345 C nuclear body
B/D=84-345 C nucleoplasm
B/D=84-345 C nucleus
B/D=84-345 C RNA polymerase II transcription regulator complex
B/D=84-345 C transcription regulator complex
B/D=84-345 F aryl hydrocarbon receptor binding
B/D=84-345 F cis-regulatory region sequence-specific DNA binding
B/D=84-345 F DNA-binding transcription factor activity
B/D=84-345 F nuclear receptor activity
B/D=84-345 F protein heterodimerization activity
B/D=84-345 F protein homodimerization activity
B/D=84-345 F protein-containing complex binding
B/D=84-345 F RNA polymerase II cis-regulatory region sequence-specific DNA binding
B/D=84-345 F sequence-specific DNA binding
B/D=84-345 F sequence-specific double-stranded DNA binding
B/D=84-345 F transcription factor binding
B/D=84-345 P cell differentiation
B/D=84-345 P embryonic placenta development
B/D=84-345 P positive regulation of hormone biosynthetic process
B/D=84-345 P positive regulation of protein sumoylation
B/D=84-345 P positive regulation of transcription by RNA polymerase II
B/D=84-345 P positive regulation of transcription, DNA-templated
B/D=84-345 P positive regulation of vascular endothelial growth factor production
B/D=84-345 P regulation of transcription from RNA polymerase II promoter in response to oxidative stress
B/D=84-345 P response to hypoxia
B/D=84-345 P response to toxic substance
Sequences
Download file with secondary structure created by Stride  
5nj8.pdb1.pdb:   [ download sequences in FASTA format ]
E (dna): 
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F (dna): 
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A (protein): 
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B (protein): 
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5nj8.pdb2.pdb:   [ download sequences in FASTA format ]
G (dna): 
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H (dna): 
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C (protein): 
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D (protein): 
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